Idiopathic Pulmonary Fibrosis and Emphysema

Mejía, Mayra; Carrillo, Guillermo; Rojas-Serrano, Jorge; Estrada, Andrea; Suárez, Teresa; Alonso, Delfino; Barrientos, Emilio; Gaxiola, Miguel; Navarro, Carmen; Selman, Moisés

doi:10.1378/chest.08-2306

Cited by 409 publications

(193 citation statements)

References 22 publications

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“…Sugino et al 10 used echocardiography and reported an average eSPAP similar to our own in Japanese patients with IPF alone or IPF and emphysema. Although the threshold of emphysematous area was 10% <on HRCT in the report by Mejía et al 8 and the difference in prevalence of PH between Mexican and Japanese CPFE patients might be due to racial differences, it is suggested that their patients were more severe than our patients according to PFT features.…”

Section: Discussioncontrasting

confidence: 56%

“…Forty-eight patients underwent echocardiography to identify complications of pulmonary hypertension (PH), which were defined as >45 mmHg estimated systolic pulmonary arterial pressure (eSPAP), based on tricuspid regurgitant pressure gradient, as reported by Mejía et al 8 In patients undergoing surgical biopsy, we confirmed diagnoses in accordance with the ATS/ERS/JRS/ALAT statement.…”

Section: Methodsmentioning

confidence: 75%

“…[8][9][10][11] Our results showed that the CPFE group revealed a significantly worse prognosis than did the non-CPFE group when the threshold of ratio of emphysematous area on HRCT was set at 25%, but no significant difference was found at 10% (Figure 1). Regarding PFTs, a large cohort study of patients with IPF suggested that a decline in FVC of more than 10% in IPF 13 and that in FEV 1 of more than 10% in moderate-to-severe CPFE 28 during a 6-month observation are the best physiological predictors of mortality.…”

Section: Discussionmentioning

confidence: 94%

“…26,27 A study by Mejía et al 8 showed high prevalence of severe PH and poor prognosis in IPF patients with emphysema in an echocardiography evaluation in Mexican patients. This study also found high eSPAP, on average in patients with IPF and emphysema.…”

Section: Discussionmentioning

confidence: 99%

“…Past reports, in which CPFE was defined as having an emphysematous area of 10% or more of the whole lung, showed uncertain prognoses [8][9][10] ; another report suggested that the prognosis of CPFE was poor when it was defined as having an emphysematous area of 25% or greater. 11 Therefore, we considered it necessary to define CPFE based on the emphysematous area reflecting prognosis.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Significance of Combined Emphysema in Idiopathic Pulmonary Fibrosis and Serum Surfactant Protein-D as a Prognostic Factor

Yokoo¹,

Shiratori²,

Ikeda³

et al. 2017

Pulm Res Respir Med Open J

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Section: Discussioncontrasting

confidence: 56%

Section: Methodsmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Significance of Combined Emphysema in Idiopathic Pulmonary Fibrosis and Serum Surfactant Protein-D as a Prognostic Factor

Yokoo¹,

Shiratori²,

Ikeda³

et al. 2017

Pulm Res Respir Med Open J

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Patient Selection and Indications for Lung Transplantation

Garrity

2014

Textbook of Organ Transplantation

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Smoking, occupational exposures, and idiopathic pulmonary fibrosis among Swedish construction workers

Andersson

Blanc

Järvholm

2021

American J Industrial Med

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Background Cigarette smoking and occupational exposures each have been reported to increase the risk of idiopathic pulmonary fibrosis (IPF), a disease previously considered of unknown origin. We investigated the risk of IPF mortality associated with combined smoking and occupational exposures. Methods A registry study of Swedish construction workers (N = 389,132), linked baseline smoking and occupational data with registry data on cause of death and hospital care diagnoses. Occupation was classified by the likelihood of exposure to vapors, gases, dusts, or fumes using a job‐exposure matrix. Those likely exposed to asbestos or silica were excluded from the analysis. Age‐adjusted relative risks [RRs] were calculated using Poisson regression. Follow‐up observation began at age 40 and ended at age 89. Results Heavy smokers at baseline who were exposed to inorganic dusts during their working life had an increased risk of IPF mortality (RR 1.70; 95% confidence interval [CI] 1.11–2.60), while there was no statistically increased risk in the other exposure groups. There were dose–response relationships between smoking at baseline and IPF mortality among both unexposed and dust exposed workers, with similar risk for dust exposed and unexposed, except among baseline heavy smokers, where workers exposed to inorganic dust manifested the highest risk (RR 4.22; 95% CI 2.69–6.60). Excluding workers with chronic obstructive pulmonary disease or emphysema did not affect the results substantively. Conclusion A clear dose–response relationship was seen between smoking at baseline and IPF, supporting a causal relationship. Occupational exposure to inorganic dusts, excluding silica and asbestos, was associated with increased risk of IPF in baseline heavy current smokers.

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Idiopathic Pulmonary Fibrosis and Emphysema

Cited by 409 publications

References 22 publications

Significance of Combined Emphysema in Idiopathic Pulmonary Fibrosis and Serum Surfactant Protein-D as a Prognostic Factor

Significance of Combined Emphysema in Idiopathic Pulmonary Fibrosis and Serum Surfactant Protein-D as a Prognostic Factor

Patient Selection and Indications for Lung Transplantation

Smoking, occupational exposures, and idiopathic pulmonary fibrosis among Swedish construction workers

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