Idiopathic paroxysmal kinesigenic dyskinesia in Malaysia, a multi-racial Southeast Asian country

Tai, Mei‐Ling Sharon; Lim, Shen‐Yang; Tan, Chong Tin

doi:10.1016/j.jocn.2009.11.034

Cited by 2 publications

(2 citation statements)

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“…The prevalence of PKD, which is the most common form of paroxysmal dyskinesias, was estimated to be 1:150,000 in the general population, with a suggestion that it may be more common in Asians, especially Chinese and Japanese, although direct comparisons of prevalence among various ethnic groups are not available 119,120 . In studies from Malaysia and Singapore, which are multi‐racial Southeast Asian countries, a preponderance of Chinese (over Malay and Indian) cases has been observed (65–90% Chinese) 121–123 . The first multicenter study in Asia was reported by Japanese investigators who analyzed 150 patients with a clinical diagnosis of PKD comprising 53 sporadic cases and 97 affected individuals from 32 pedigrees with a majority compatible with AD inheritance 124 .…”

Section: Resultsmentioning

confidence: 99%

“…119,120 In studies from Malaysia and Singapore, which are multi-racial Southeast Asian countries, a preponderance of Chinese (over Malay and Indian) cases has been observed (65-90% Chinese). [121][122][123] The first multicenter study in Asia was reported by Japanese investigators who analyzed 150 patients with a clinical diagnosis of PKD comprising 53 sporadic cases and 97 affected individuals from 32 pedigrees with a majority compatible with AD inheritance. 124 The mean age of onset was 8.8 years with male predominance (80%).…”

Section: Paroxysmal Kinesigenic Dyskinesia; Pxmd-prrt2; Pkd-prrt2mentioning

confidence: 99%

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Genetic Movement Disorders Commonly Seen in Asians

Jagota

Lim

Pal

et al. 2023

Movement Disord Clin Pract

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The increasing availability of molecular genetic testing has changed the landscape of both genetic research and clinical practice. Not only is the pace of discovery of novel disease-causing genes accelerating but also the phenotypic spectra associated with previously known genes are expanding. These advancements lead to the awareness that some genetic movement disorders may cluster in certain ethnic populations and genetic pleiotropy may result in unique clinical presentations in specific ethnic groups. Thus, the characteristics, genetics and risk factors of movement disorders may differ between populations. Recognition of a particular clinical phenotype, combined with information about the ethnic origin of patients could lead to early and correct diagnosis and assist the development of future personalized medicine for patients with these disorders. Here, the Movement Disorders in Asia Task Force sought to review genetic movement disorders that are commonly seen in Asia, including Wilson's disease, spinocerebellar ataxias (SCA) types 12, 31, and 36, Gerstmann-Sträussler-Scheinker disease, PLA2G6-related parkinsonism, adult-onset neuronal intranuclear inclusion disease (NIID), and paroxysmal kinesigenic dyskinesia. We also review common disorders seen worldwide with specific mutations or presentations that occur frequently in Asians.

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Section: Resultsmentioning

confidence: 99%