Idiopathic or mesothelioma‐related pericardial effusion: clinical findings and survival in 17 dogs studied retrospectively

Stepien, Rebecca L.; Whitley, Nat; Dubielzig, Richard R.

doi:10.1111/j.1748-5827.2000.tb03215.x

Cited by 68 publications

(64 citation statements)

References 15 publications

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“…Differentiation between some neoplastic and non-neoplastic hyperplastic processes (epithelial dysplasia, connective tissue hyperplasia, postinflammatory epithelial changes) can be difficult or even impossible based on cytopathology only (Stepien et al 2000, Geninet et al 2003, Sato et al 2005, Ordonez 2006, Szczepulska-Wójcik et al 2007, Bertazzolo et al 2012. Some additional diagnostic methods, such as the surgical biopsies of lesions or specialized immunohistochemical (IHC) or immunocytochemical (ICC) staining, that are required in differential diagnosis of tumors within serosal cavities and are considered to be a "gold standard", are not readily available in veterinary medicine at present (Bertazzolo et al 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Diagnostic procedure in such cases requires introduction of other diagnostic methods, from non-invasive or low-invasive (e.g. visualization techniques) to highly invasive procedures, such as surgical intervention, involving tissue sample collection (Sisson et al 1984, Stepien et al 2000, Geninet et al 2003, Brisson et al 2006, Szczepulska-Wójcik et al 2007.…”

Section: Introductionmentioning

confidence: 99%

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Using of immunocytochemistry in differential diagnosis of neoplasms of serosal cavities in dogs

Przeździecki¹,

Sapierzyński²

2014

Polish Journal of Veterinary Sciences

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The presence of tumor within the serosal cavities, often connected with accumulation of serosal effusion, is a quite common problem in the small animal veterinary medicine. The first step in diagnosis of such cases is cytopathological examination. The aim of the present study was to evaluate the usefulness of cytology and immunocytochemistry, using commercially available antibodies (anti-cytokeratin, anti-vimentin, and anti-desmin), in differential diagnosis of malignant tumors located within serosal cavities in dogs. The final cytological diagnosis of carcinoma/adenocarcinoma, sarcoma, and mesothelioma was obtained on the basis of routine cytopathology and immunocytochemistry, and then confirmed by histopathology and immunohistochemistry. Cytoplasmic immunoreactivitiy of normal mesothelid cells and cytoplasmic immunoreactivity of hyperplastic mesothelial cells revealed constant and strong expression of all examined intermediate filaments: cytokeratin, vimentin and desmin. Application of routine cytopathology and immunocytochemistry allowed 32 neoplastic tumors to be detected: 19 cases of carcinomas/adenocarcinomas, 6 cases of sarcomas, 7 cases of mesotheliomas. Immunostaining of cytopathological samples with chosen set of antibodies: anti-cytokeratin, anti-vimentin, anti-desmin is a useful, and low invasive test for differentiation between mesotheliomas and carcinomas/adenocarcinomas in dogs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Using of immunocytochemistry in differential diagnosis of neoplasms of serosal cavities in dogs

Przeździecki¹,

Sapierzyński²

2014

Polish Journal of Veterinary Sciences

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“…Therefore, cytological findings must be associated with clinical signs present in the dog (Cagle et al 2014,Stepien et al 2000. However, the diagnostic possibilities using cytology are varied but increase when the pericardial fluid has a hematocrit <10% (Cagle et al 2014, de Lafourcade et al 2007.…”

Section: Resultsmentioning

confidence: 99%

“…But, the definitive non neoplastic diagnosis was made using echocardiographic checkups during 8 months ruled out the presence of pericardial disease. Retrospective echocardiographic studies detected that 60% of the dogs with idiopathic pericardial effusion have reactive mesothelial cells without echocardiographic evidence of mesotheliomas during a period at more than 120 days (MacGregor et al 2004, Rajagopalan et al 2013, Stepien et al 2000.…”

Section: Resultsmentioning

confidence: 99%

Pericardial effusion and cardiac tamponade in a dog with hypothyroidism

et al. 2015

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Pericardial effusion and cardiac tamponade in a dog with hypothyroidismEfusión pericárdica y taponamiento cardíaco en un perro con hipotiroidismo J Ojeda * , M Mieres, C Dunner, N Sagredo, H Bustamante Department of Veterinary Clinical Sciences, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile. RESUMENLa relación entre hipotiroidismo y enfermedades cardiovasculares en perros frecuentemente está asociada con la presencia de signos clínicos como bradicardia sinusal, alteraciones miocárdicas y complejos QRS de bajo voltaje y onda T invertida en el electrocardiograma. Varios estudios en perros hipotiroideos no han mostrado la presencia de efusión pericárdica, sin embargo, en humanos es bien conocida la presencia de efusión pericárdica asociada a hipotiroidismo, pero el taponamiento cardiaco no es un signo frecuente. Un perro Golden Retriever fue presentado con historial clínico de letargia progresiva, intolerancia al ejercicio, intolerancia al frío y dificultad respiratoria durante 3 semanas. Al examen clínico el perro presentó disnea, tonos cardiacos tenues e hipertensión. El examen ecocardiográfico demostró la presencia de fluido en el saco pericárdico y taponamiento cardiaco. Se realizó una pericardiocentesis y el análisis citológico del fluido descartó la presencia de células neoplásicas. La información entregada por los propietarios, además de la detección de zonas alopécicas en cola y abdomen sumado a la evolución clínica llevó a analizar las hormonas tiroideas, confirmando el hipotiroidismo. Una vez realizadas dos pericardiocentesis y posterior suplementación con hormonas tiroideas clínicos no presentaron recurrencia. Aunque la etiología de la efusión pericárdica no fue confirmada es posible que el hipotiroidismo haya causado la efusión pericárdica, o bien el perro padeció una efusión pericárdica idiopática y coincidentemente hipotiroidismo. Sin embargo, de acuerdo con los signos clínicos descritos y evolución de este caso, se sugiere que aun cuando la efusión pericárdica es un signo no descrito en el hipotiroidismo canino, se debe considerar la evaluación de las hormonas tiroideas en perros con efusión pericárdica idiopática.Palabras clave: hipotiroidismo, efusión pericárdica, taponamiento cardíaco, perros. SUMMARYThe relationship between hypothyroidism and cardiovascular diseases in dogs is frequently associated with clinical signs like sinusal bradicardia, myocardial alterations and ECG findings such as low voltage QRS and inverted T wave. Echocardiographic studies in hypothyroid dogs have not identified pericardial effusion. Hypothyroidism in human patients is a well-known cause of pericardial effusion, but cardiac tamponade is not a frequent clinical sign. A Golden Retriever was presented with a clinical history of progressive lethargy, exercise intolerance, cold intolerance and increased respiratory effort for 3 weeks. At the clinical examination the dog presented dyspnea, muffled heart sound and hypertension. Echocardiography showed fluid in the pericardial sac and cardiac ...

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“…Dogs treated with intrathoracic and intravenous cisplatin or intravenous doxorubicin remained free of disease for 27 months [2]. In another report, a dog survived for 300 days after a doxorubicin and intracavitary cisplatin treatment [15]. In this case, we elected to offer intravenous cisplatin as a trial therapy for the dog because the tumor lesions were widespread (peritoneal and pleural).…”

mentioning

confidence: 99%

Palliative Intravenous Cisplatin Treatment for Concurrent Peritoneal and Pleural Mesothelioma in a Dog

Seo

Choi

Jung

et al. 2007

The Journal of Veterinary Medical Science

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ABSTRACT. A 10-year-old Maltese dog was presented with abdominal distention and dyspnea. Cytological examination of pleural and peritoneal effusion was suggestive of malignant effusion of glandular origin. Numerous, multifocal, tan to white nodules were disseminated throughout the surface of the abdominal organs and peritoneum at biopsy. Histologically, the tumors were revealed to be an epithelial type of mesothelioma. Neoplastic cells co-expressed cytokeratin and vimentin. Intravenous administration of cisplatin was chosen as the treatment. During treatment, the dog's overall body condition improved and the clinical signs were relieved without significant side effects. The survival time from diagnosis to sudden death by unknown cause was 153 days.

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Idiopathic or mesothelioma‐related pericardial effusion: clinical findings and survival in 17 dogs studied retrospectively

Cited by 68 publications

References 15 publications

Using of immunocytochemistry in differential diagnosis of neoplasms of serosal cavities in dogs

Using of immunocytochemistry in differential diagnosis of neoplasms of serosal cavities in dogs

Pericardial effusion and cardiac tamponade in a dog with hypothyroidism

Palliative Intravenous Cisplatin Treatment for Concurrent Peritoneal and Pleural Mesothelioma in a Dog

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