Idiopathic nodular glomerulosclerosis in Chinese patients: a clinicopathologic study of 20 cases

Abstract

ING is rare and appears to be associated with overweight, hypertension and cigarette smoking in Chinese patients.

Diabetic Nephropathy without Diabetes

“…Some additional features of DN such as capsular drop lesions, glomerular hyalinosis, areas of mesangiolysis, and microaneurysms may also be observed. Different degrees of glomerulomegaly have been described in some studies [ 8 , 10 ] but not in others [ 27 ] nor in our study.…”

“…In order to have homogeneity as to the diagnostic criteria and recorded data, records published before 1999 were excluded ( n = 14). Twenty-two records were included [ 3 , 4 , 5 , 6 , 8 , 9 , 10 , 11 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ], from 25 screened records. Three were excluded because they did not meet criteria for precise diagnosis.…”

“…We used meta-analysis methods to estimate the pooled prevalence of risk factors [ 32 ]. Series with more than five cases [ 8 , 9 , 10 , 13 ] were included in this analysis. Pooled prevalence was estimated with fixed effect models and random effects models in case of high heterogeneity.…”

“…Until now the histological features associated with renal prognosis have been the interstitial fibrosis [ 8 , 10 ], the arteriosclerosis [ 8 ] and the arteriolar hyalinosis although the latter is not acknowledged in all the cases. In our analysis the tubulointerstitial fibrosis and tubular atrophy (IFTA) and the arteriolar hyalinosis/sclerosis (AH/S) are very important prognostic factors.…”

“…Three main studies in the literature [ 8 , 9 , 10 ] and a previous review [ 11 ] demonstrate evidence in many cases where no IGM alteration has been detected, neither at biopsy nor in the follow up period of the patients. ING cases are mostly found in patients with hypertension, smokers and with overweight/obesity.…”