Idiopathic Localized Involutional Lipoatrophy: A Lupus Profunds-like Condition

Idiopathic localized involutional lipoatrophy: A retrospective study of 12 cases

“…in 1996 observed the distinct histological pattern of adipocytes and classified the variant as ILIL. [1] ILIL is a rare condition characterized by asymptomatic lipoatrophy on one or few sites, occurring without any triggering factor and regressing spontaneously within a few months. [12] However, in inflammatory lipoatrophy, multiple lesions of lipoatrophy with histopathological findings of normal lipocytes associated with diffuse infiltrate of lymphocytes, histiocytes, and plasma cells in fat lobules is seen.…”

“…Childhood cases reported in literature are rare, and the maximum cases reported were young adults (females). There is single case report of childhood (5 years)[19] and elderly involvement at 67 years of age;[1] however, we had more number of children when compared with adults. Sites commonly involved are arms, buttocks, thighs, and abdomen in most reported cases.…”

“…It is characterized by specific focal loss of adipose tissue without antecedent inflammation. [1] A majority of the studies reported in literature have described inflammatory localized involutional lipoatrophy with history of previous injections, drugs, or trauma. To the best of our knowledge, there are no studies that have described true idiopathic variant of localized involutional lipoatrophy in a significant number of cases.…”

Lipoatrophy Associated With Maxillary Bone Graft for the Purpose of Dental Implants and Correction by Fat Grafting: A Case Report

“…[56][57][58][59] Differential diagnosis usually includes other types of lipoatrophy/lipodystrophy, postinjection panniculitis, atrophoderma, lupus profundus, and localized scleroderma. 52,55,60 The condition mostly involves proximal extremities and buttocks and is more frequent in women. This might imply the involvement of female hormones or their receptors in the pathogenesis of this kind of lipoatrophy.…”

Localised involutional lipoatrophy: a case report

“…www.odermatol.com [2], morphea [3], lichen sclerosus et atrophicus [3], and other types of lipoatrophy associated with triggers like repeated injections with corticosteroids and antibiotics [4][5][6] or sites of trauma [7]. These disorders can be differentiated from LIL based on the latter's characteristic histopathological feature, which is the presence of diminutive fat lobules composed of small adipocytes that resemble fetal fat tissue without the presence of inflammation.…”