Idiopathic Intracranial Hypertension (Pseudotumor Cerebri): Descriptive Epidemiology, Clinical Features, and Visual Outcome in Parma, Italy, 1990 to 1999

Carta, Arturo; Bertuzzi, Francesca; Cologno, Daniela; Giorgi, Claudia; Montanari, E.; Tedesco, SA

doi:10.1177/112067210401400108

Cited by 56 publications

(32 citation statements)

References 35 publications

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“…suggested in the revised diagnostic criteria for pseudotumor cerebri syndrome (Table 2) [Friedman et al 2013]. Other symptoms and clinical signs include dizziness, nausea, reduced memory and concentration and horizontal diplopia due to sixth nerve palsy [Carta et al 2004;Mollan et al 2014;Yri and Jensen, 2015;Yri et al 2012]. Recent studies demonstrated a marked cognitive dysfunction [Kharkar et al 2011;Yri et al 2014a;Zur et al 2015] and indicated that impaired executive function, working memory, processing speed and reaction time remained after normalization of ICP and alleviation of the headache and the visual symptoms [Yri et al 2014a].…”

Section: Clinical Presentation and Diagnosismentioning

confidence: 99%

“…At time of diagnosis various degrees of visual impairment are present in up to 90% of patients with IIH [Craig et al 2001] and in prior studies an estimated rate of 10-24% progressed to severe and permanent visual impairment [Carta et al 2004;Durcan et al 1988]. Visual loss can occur anytime along the course of the disease but is often insidious and as central vision is spared until late in the course of the illness the visual loss is often asymptomatic until profound.…”

Section: Introductionmentioning

confidence: 99%

“…Although assessment of papilledema may be limited by considerable intra-and inter-observer variability and lack of experience in junior doctors, is it still a quick, simple and accessible bedside test in the emergency room. Test of vision and especially visual field by perimetry are also essential [Carta et al 2004;Mollan et al 2014;Skau et al 2011a] but the test method should be standardized and in most cases needs ophthalmological expertise. Use of optical coherence tomography (OCT) is recommended for quantification of papilledema and the method has been demonstrated to be a valuable additional tool for identification and monitoring of papilledema over time [Skau et al 2011a;El-Dairi et al 2007;Rebolleda and Munoz-Negrete, 2009].…”

Section: Examinationmentioning

confidence: 99%

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The diagnosis and management of idiopathic intracranial hypertension and the associated headache

Jensen

Radojičić

Yri

2016

Ther Adv Neurol Disord

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Idiopathic intracranial hypertension (IIH) is a challenging disorder with a rapid increasing incidence due to a close relation to obesity. The onset of symptoms is often insidious and patients may see many different specialists before the IIH diagnosis is settled. A summary of diagnosis, symptoms, headache characteristics and course, as well as existing evidence of treatment strategies is presented and strategies for investigations and management are proposed.

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Section: Clinical Presentation and Diagnosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Examinationmentioning

confidence: 99%

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The diagnosis and management of idiopathic intracranial hypertension and the associated headache

Jensen

Radojičić

Yri

2016

Ther Adv Neurol Disord

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“…On average, the incidence of IIH in the general population is 0.5-1.0/100,000 [8,27,28,29,30]. The general population numbers appear to be lower in some Asian countries [31] and higher in Libya [32] and the UK [33].…”

Section: Epidemiology and Obesitymentioning

confidence: 99%

Idiopathic Intracranial Hypertension and Obesity

Andrews

Liu

Ko³

2014

Horm Res Paediatr

100

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Idiopathic intracranial hypertension (IIH), also known as primary pseudotumor cerebri syndrome (PTCS), is a condition of unknown etiology which affects primarily overweight, reproductive-aged women and causes increased intracranial pressure (ICP). This review discusses the recently revised diagnostic criteria for PTCS for adults and children. Additionally, the role of obesity in the epidemiology, etiology, and management of IIH as well as the current knowledge of obesity profiles and markers in IIH are reviewed. We also highlight the emerging, unifying theory of the neuroendocrine effects on the mineralocorticoid receptor to explain a possible mechanism for the increased cerebrospinal fluid production and ICP in secondary PTCS.

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“…[1][2][3][4][5][6][7] Prognosis is variable, with severe visual loss occurring in up to 10% of cases.8 Although few series have specifically evaluated racial differences in IIH, it has been suggested that black patients may have more severe outcomes from IIH.9 -11 The purpose of this study was to compare the characteristics of IIH in blacks and nonblacks.…”

Section: Introductionmentioning

confidence: 99%

Racial differences in idiopathic intracranial hypertension

Bruce

Preechawat²,

Newman³

et al. 2008

Neurology

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Objective-To evaluate racial differences in idiopathic intracranial hypertension (IIH).Methods-Medical records of all consecutive patients with definite IIH seen between 1989 and 2006 were reviewed. Demographics, associated factors, and visual function at presentation and follow-up were collected. Black patients were compared to non-black patients. (197 black, 253 non-black). Obesity, systemic hypertension, anemia, and sleep apnea were more common in blacks than in non-blacks (p≤0.01). Cerebrospinal fluid opening pressure was higher in blacks (40 vs. 34 cm CSF, p<0.001). Visual acuity, visual field loss, and degree of papilledema at presentation and follow-up were worse in blacks (p≤0.01). Diagnostic and therapeutic measures were similar between blacks and non-blacks, except for optic nerve sheath fenestration (p=0.01) and lumbar puncture (p=0.03), both more commonly performed on black patients. The relative risk of severe visual loss for blacks compared with non-blacks was 3.5 (95%CI 2.0-5.8, p<0.001) in at least one eye and 4.8 (95%CI 2.1-10.9, p<0.001) in both eyes. Logistic regression analysis supported race, anemia, body mass index, and male gender as independent risk factors for severe visual loss and suggested that racial differences may be partially accounted for by differences in CSF opening pressure, body mass index, and frequency of anemia. Results-We included 450 patientsConclusion-Black IIH patients were more likely than non-black IIH patients to have severe visual loss in at least one eye. This difference did not appear to result from diagnosis, treatment, or access to care, but may partially relate to differences in other risk factors. Black patients have a more aggressive disease and may need closer follow-up and lower thresholds for early intervention.

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Idiopathic Intracranial Hypertension (Pseudotumor Cerebri): Descriptive Epidemiology, Clinical Features, and Visual Outcome in Parma, Italy, 1990 to 1999

Cited by 56 publications

References 35 publications

The diagnosis and management of idiopathic intracranial hypertension and the associated headache

The diagnosis and management of idiopathic intracranial hypertension and the associated headache

Idiopathic Intracranial Hypertension and Obesity

Racial differences in idiopathic intracranial hypertension

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