Idiopathic Intracranial Hypertension in a Woman With Schizophrenia

Abstract

ABSTRACT:Idiopathic intracranial hypertension (IIH) or benign intracranial hypertension is a neurological syndrome characterized by elevated intracranial pressure. This uncommon disorder occurs primarily in obese women aged 10 to 50 years, sometimes in association with endocrine and metabolic dysfunction, with systemic diseases or when treated with multiple medications.We describe a case of IIH in a 43-year-old woman with schizophrenia treated with risperidone, demonstrating a typical clinical picture of benign intracranial hypertension. For the 5 years of treatment with risperidone she put on 35 kg in total (BMI> 35); for the last 2-3 months she began to complain of visual obscurations, nausea with vomiting. Ophthalmoscopy revealed bilateral asymmetric papilledema (OD>OS). Magnetic resonance imaging was normal, intracranial pressure was elevated IIH was diagnosed. Risperidone was discontinued and replaced with Seroquel 200 mg daily. Treatment with furosemide and mannitol 10% was initiated. Papilledema resolved completely over the next 2 months. The patient was followed-up for four years after risperidone withdrawal. Weight loss of 28 kg was noted for four years. There were no relapses of headache, nausea, visual obscuration. Ophthalmologic examination revealed no papilledema.We suggest that prolonged use of antipsychotics, such as risperidone, should require proper surveillance for possible development of IIH and routine ophthalmologic examinations should be performed.

Risperidone Induced Benign Intracranial Hypertension Leading to Visual Loss

“…To the best of our knowledge, only four such risperidoneinduced cases have been reported in world literature with none from India. [2][3][4][5] We report this case for its rare but serious morbidity occurring with a common antipsychotic medication. Differential diagnosis considered included meningitis, cortical venous thrombosis, demyelinating illness with optic neuritis, and idiopathic intracranial hypertension.…”

Risperidone and Intracranial Hypertension: A Case Report and Literature Review

“…4 To our knowledge, 5 cases have been described in the literature that report a link between risperidone and IH ( Table 1). [1][2][3]5,6 In 4 of 5 cases, the IH may have been induced by a significant weight gain after risperidone. But in 1 pediatric case, the IH was not consecutive to a weight gain.…”