Idiopathic Inflammatory Myopathy: Clinicopathological Observations in the Indian Population

Prasad, Manju L.; Sarkar, Chitra; Roy, S.; Bagchi, U.; Singh, Ratnakar; Singh, Y. N.; Sharma, Surinder K.; Malaviya, A. N.

doi:10.1093/rheumatology/31.12.835

Cited by 15 publications

(12 citation statements)

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“…The largest studies contributed to more than a half of all the patients [25]. 7 studies were done in East Asia [21–25, 27, 28], 3 studies were done in South East Asia [17, 19, 29], 2 studies were conducted in South Asia [16, 20], and the other 2 studies were from the Middle East [18, 26]. …”

Section: Resultsmentioning

confidence: 99%

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Clinical Features of Inflammatory Myopathies and Their Association with Malignancy: A Systematic Review in Asian Population

et al. 2013

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Introduction. Idiopathic inflammatory myopathies (IIMs) are a group of chronic systemic autoimmune diseases that mainly affect the skeletal muscle. The common subtypes include adult dermatomyositis (DM), polymyositis (PM), and inclusion body myositis (IBM). Most of the earlier studies that described the clinical characteristics of IIM as well as their association with cancer were conducted in Western population. Our study is the first systematic review that summarizes the clinical data of DM/PM in Asian population. Methods. We identified 14 case series of DM/PM that met our eligibility criteria. We then compared this data with that from previous reports from Europe and North America. Results. Our systematic review included 2518 patients. Dermatomyositis is more common, with the ratio of dermatomyositis to polymyositis being 1.36 : 1. 69% of them were females with mean age of 45.5 years. Extramuscular manifestations, including arthritis/arthralgia, dysphagia, and interstitial lung disease, are found in one-third of the patients. Malignancy was found in 10% of patients, with lung and nasopharyngeal carcinomas being the most common malignancies associated with these myopathies. Conclusion. Clinical presentation of PM/DM appears to be similar in both Western and Asian populations. However, the type of associated malignancies in Asians differs from that in Caucasians. Ethnic background should be one of the factors that clinicians should consider while screening for malignancy.

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Section: Resultsmentioning

confidence: 99%

“…14 case series met our inclusion criteria and were included for data analysis [16–29]. Figure 1 outlines our search methodology and selection process.…”

Section: Data Assessmentmentioning

confidence: 99%

Clinical Features of Inflammatory Myopathies and Their Association with Malignancy: A Systematic Review in Asian Population

et al. 2013

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“…In contrast to our findings, Prasad et al . [12] reported that patients who had myositis associated with CTD had significantly more vasculitis than either idiopathic PM patients or idiopathic DM patients. Ringel et al .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, data regarding the differences in the muscle pathology findings between subgroups of IIM have been limited. Furthermore, discrepancies of data regarding the correlation of histo-morphological muscle alterations with clinical and laboratory parameters in IIM among the different studies have been reported [8, 9, 11, 12]. …”

Section: Introductionmentioning

confidence: 99%

The Correlation of Muscle Biopsy Scores with the Clinical Variables in Idiopathic Inflammatory Myopathies

Wangkaew

Suwansirikul

Aroonrungwichian

et al. 2016

TORJ

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Objectives: To compare the muscle pathology findings among subgroups of idiopathic inflammatory myopathies (IIM) patients, and to determine the correlations of muscle biopsy scores with muscle power and creatine kinase (CK).Methods:The medical records of IIM patients consisting of the demographic data, clinical parameters and laboratory conducted were retrospectively reviewed. Their initial muscle biopsies were reviewed, and four domains were scored: inflammation, vascular, muscle, and connective tissue.Results: Ninety-five IIM patients (28 patients with idiopathic polymyositis (PM) 9 idiopathic dermatomyositis (DM), 5 DM associated with malignancy, and 53 PM/DM associated with connective tissue disease) with median (IQR: Q1, Q3) disease duration of 1.2 (0.5, 3.1) months were included. No significant differences in initial muscle pathology findings and muscle pathology score among the subgroups were found. Muscle degeneration and endomysial fibrosis scores were negatively correlated with muscle power (r=-0.23 and-0.24, respectively, p<0.05) and positively correlated with CK (r=0.27 and 0.39, respectively, p<0.01). No significant correlation was detected either inflammation or vasculitis scores with muscle power and CK levels.Conclusion:In this study, muscle biopsy cannot be used to differentiate among subgroups of IIM patients. In addition, we found only modest correlation of muscle biopsy scores with muscle power and CK. Further study is necessary to confirm our findings.

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“…Although case series of DM/PM have been reported from India, 4–6 data on malignancy‐associated DM/PM is sparse. Only one report 6 has mentioned ‘11% malignancy’ in a series of 73 cases’ but details of those patients are not available.…”

Section: Introductionmentioning

confidence: 99%

Dermatomyositis/polymyositis associated with malignancy: our experience with ten patients and review of relevant literature

Tembe

Ramteke

et al. 2008

Int J of Rheum Dis

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Objective: To analyse the clinical and laboratory data of patients diagnosed with malignancy associated dermatomyositis/polymyositis (DM/PM) seen between January 2002 and February 2007. Methods: The demographic, clinical, treatment and follow‐up data from the case records of all 10 patients diagnosed with malignancy‐associated inflammatory muscle diseases (IMD) namely, DM/PM, were entered in a proforma and analysed. Results: In patient nos. 1–8, malignancy was diagnosed prior to the diagnosis of myositis; in patient no. 9, it was detected during screening and patient no. 10 developed breast cancer 5 years after PM diagnosis. All the patients had typical clinical and laboratory features of IMD, except two patients, who had amyopathic dermatomyositis with predominantly cutaneous features, creatine kinase levels less than two times the upper limit of normal and minimal muscle weakness. Breast cancer (6/10) and ovarian cancer (3/10) were the most commonly associated malignancies. All but one (patient no. 8) responded to treatment. Malignancy relapsed in four patients with concurrent relapse of myositis in three. These three patients died of the malignancy. One patient was lost to follow‐up. The mean duration of follow‐up in others was 21 months (range 12–60 months). Conclusion: DM is more commonly associated with malignancy. Carcinoma of the breast was the most commonly associated malignancy. Myositis responded in most patients. Death was due to the underlying malignancy. In most cases, the two conditions occur within 1 year.

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Idiopathic Inflammatory Myopathy: Clinicopathological Observations in the Indian Population

Cited by 15 publications

References 0 publications

Clinical Features of Inflammatory Myopathies and Their Association with Malignancy: A Systematic Review in Asian Population

Clinical Features of Inflammatory Myopathies and Their Association with Malignancy: A Systematic Review in Asian Population

The Correlation of Muscle Biopsy Scores with the Clinical Variables in Idiopathic Inflammatory Myopathies

Dermatomyositis/polymyositis associated with malignancy: our experience with ten patients and review of relevant literature

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