Idiopathic inflammatory myopathy and non-coding RNA

Abstract

Idiopathic inflammatory myopathies (IIMs) are common autoimmune diseases that affect skeletal muscle quality and function. The lack of an early diagnosis and treatment can lead to irreversible muscle damage. Non-coding RNAs (ncRNAs) play an important role in inflammatory transfer, muscle regeneration, differentiation, and regulation of specific antibody levels and pain in IIMs. ncRNAs can be detected in blood and hair; therefore, ncRNAs detection has great potential for diagnosing, preventing, and treating IIMs in conjunction with other methods. However, the specific roles and mechanisms underlying the regulation of IIMs and their subtypes remain unclear. Here, we review the mechanisms by which micro RNAs and long non-coding RNA-messenger RNA networks regulate IIMs to provide a basis for ncRNAs use as diagnostic tools and therapeutic targets for IIMs.

Transcriptome Analysis of miRNA and mRNA in Porcine Skeletal Muscle following Glaesserella parasuis Challenge

“…In many cases, miRNAs have been found to be involved in pathological and physiological stress [ 25 , 26 , 27 , 28 ]. Dysregulated expression of miRNAs in skeletal muscle-related diseases suggests their potential role in protecting or exacerbating skeletal muscle during disease [ 29 , 30 , 31 , 32 ]. Some miRNAs have been identified as non-invasive biomarkers for muscular dystrophy [ 33 ], while others have been shown to inhibit muscle atrophy and renal fibrosis or contribute to therapeutic protein restoration [ 34 , 35 , 36 ].…”