Idiopathic Hypoparathyroidism With Primary Ovarian Failure

Preventive effect of swim bladder hydrolysates on cyclophosphamide‐induced ovarian injury in mice

“…Therefore, one of the mechanisms by which SBH protects ovarian function may be that SBH can reduce cell apoptosis and protect the apoptosis of follicles at all levels by repairing the DNA breakage caused by CTX. Some studies suggested that the occurrence and development of ovarian injury and POF were closely related to T lymphocyte abnormalities, 51 increasing number of studies have focused on the relationship between POF, cellular immunity, and cytokine abnormalities. Immune disorders in patients with POF are related to the destruction of the steady‐state balance of T lymphocytes, and it may be that T lymphocytes stimulate B cells to produce corresponding antibodies by synthesizing and secreting cytokines, which may act on ovarian tissue, cause ovarian damage, and finally trigger POF 52,53 …”

Autoimmune Hypoparathyroidism

“…[66][67][68][69][70] Several APS1 patients with candidiasis developed severe multiple endocrine gland hypofunction-sometimes in succession involving the parathyroid, adrenal, and thyroid glands as well as ovaries. 47, 66 The pituitary gland has not been directly affected, although hypopituitarism due to a pituitary tumor has been reported, and growth hormone deficiency has been described.…”

“…80 Occasionally, there is cutaneous infection with other fungi, such as Trichophytonrubrum. 70,73 Recurrent staphylococcal infections of the skin are also common. 62 Alopecia totalis is another frequently mentioned complication.…”

“…62 Alopecia totalis is another frequently mentioned complication. 25,51,63,64,70 There can also be alopecia areata, 23,25,36,63,73 piebaldism, 73 or vitiligo. 63,71 Alopecia occurs in about 30% of affected individuals, and may include loss of eyebrows and eyelashes.…”