Idiopathic histiocytoid Sweet syndrome with a butterfly rash‐like appearance: A confusing case histologically mimicking rosacea‐like dermatitis

Kiyohara, Takahiro; Shimada, Saori; Ohnishi, Sayuri; Miyamoto, Mari; Shijimaya, Takako; Nagano, Naoko; Nakamaru, Sei; Makimura, Kaoru; Tanimura, Hirotsugu

doi:10.1111/1346-8138.15097

Cited by 1 publication

(2 citation statements)

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“…It is unclear if the treatment for histiocytoid SS should differ from those for other SS variants. Several cases of histiocytoid SS have been shown to regress completely with steroid treatment [63][64][65], while one case of histiocytoid SS refractory to steroid therapy has been recently described [66]. Once again, larger studies of patients with histiocytoid SS would help elucidate the best treatment options for this variant.…”

Section: Histiocytoid Sweet Syndromementioning

confidence: 98%

“…In recent literature, SS has been reported to mimic cutaneous T-cell lymphoma [101], leprosy [102][103][104], leukemia cutis [105,106], Mycobacterium haemophilum infection [107], RAS-associated autoimmune leukoproliferative disease, rheumatoid neutrophilic dermatoses [108], secondary syphilis [109], and synovitis acne pustulosis hyperostosis syndrome [110]. Conversely, SS has been reported to be mimicked by cutaneous metastasis [111] and rosacea-like dermatitis [63]. We summarize the possible differential diagnoses in Table 4.…”

Section: Differential Diagnosismentioning

confidence: 99%

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New Practical Aspects of Sweet Syndrome

et al. 2022

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Sweet syndrome (SS), or acute febrile neutrophilic dermatosis, is an inflammatory, non-infectious skin reaction characterized clinically by tender, erythematous papules/plaques/pustules/nodules commonly appearing on the upper limbs, trunk, and head and neck; histologically, SS is characterized by dense neutrophilic infiltrate in the dermis. SS is accompanied by fever; an elevation of inflammatory markers (e.g., erythrocyte sedimentation rate, C reactive protein) in serum may also be observed. Although most cases of SS are idiopathic, SS also occurs in the setting of malignancy or following administration of an associated drug. SS has also been reported in association with pregnancy and a burgeoning list of infectious (most commonly upper respiratory tract infections) and inflammatory diseases; likewise, the litany of possible iatrogenic triggers has also grown. Over the past several years, a wider spectrum of SS presentation has been realized, with several reports highlighting novel clinical and histological variants. Corticosteroids continue to be efficacious first-line therapy for the majority of patients with SS, although novel steroid-sparing agents have been recently added to the therapeutic armamentarium against refractory SS. New mechanisms of SS induction have also been recognized, although the precise etiology of SS still remains elusive. Here, we catalogue the various clinical and histological presentations of SS, summarize recently reported disease associations and iatrogenic triggers, and review treatment options. We also attempt to frame the findings of this review in the context of established and emerging paradigms of SS pathogenesis.

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