Idiopathic guttate hypomelanosis‐like lesions in patients with mycosis fungoides: a new adverse effect of phototherapy

Friedland, Rivka; David, Michael; Feinmesser, Meora; Fenig-Nakar, S; Hodak, Emmilia

doi:10.1111/j.1468-3083.2010.03571.x

Cited by 17 publications

(17 citation statements)

References 23 publications

(102 reference statements)

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“…Literature reports encourage results obtained with bath-PUVA in the treatment of several inflammatory [38][39][40][41][42][43][44][45][46][47] and lymphoproliferative skin diseases [48][49][50][51][52]. Figures 1-4 report same examples of results obtained with bath-PUVA at our center.…”

Section: Topical Photochemotherapy: Bath-puvasupporting

confidence: 62%

Effectiveness and Safety of Topical Phototherapy in the Treatment of Dermatological Diseases

Delrosso¹,

Savoia²

2017

Photomedicine - Advances in Clinical Practice

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Phototherapy consists in the use of ultraviolet (UV) radiation from artificial sources for therapeutic purposes. Despite the introduction of new and powerful drugs (including biological and target therapies), phototherapy remains an established, lower cost, and effective option for the treatment of many common skin diseases. In systemic photochemotherapy or PUVA, photosensitizing agents of the family of Psoralens are used in combination with UVA, i.e. with long wave ultraviolet radiation. Psoralens strongly enhance the effect of UVA alone, as they interact with biological macromolecules, causing the production of oxygen free radicals within the photoactivated cells. However, systemic administration of psoralens can be problematic, causing possible negative interactions with other drugs and the onset of serious side effects. To counteract these limitations, it has been developed the bath-PUVA therapy, which consists in the topical administration of psoralens by bathing the whole body surface in an alcoholic solution of 8-methoxypsoralen (8-MOP); immediately afterwards this pretreatment, the patient is UVA-irradiated. This technique has several advantages over conventional PUVA, including the use of a reduced UVA dosage, thus resulting in minimal skin damage with complete elimination of skin photosensitivity within three hours after the treatment; furthermore, it virtually eliminates systemic side effects and drug interference due to the very limited percutaneous absorption of psoralens. Bath-PUVA is indicated and effective in the treatment of many chronic inflammatory dermatoses (including psoriasis, atopic and allergic dermatitis, lichen ruber planus, chronic urticaria, and mastocitosis), autoimmune skin diseases (including vitiligo, and alopecia aerata), and premalignant/malignant lymphoproliferative conditions (including actinic reticulosis, parapsoriasis, and early stages of mycosis fungoides). Chronic and refractory pruritus and graft-versus-host diseases can also benefit from bath-PUVA. Another emerging PUVA technique is gel-PUVA, which is based on the application of a gel-based formulation of 8-MOP on affected skin areas , followed by UVA radiation. The formulation of 8-MOP-containing gels is conceived to increase bioavailability, limit its spread to adjacent skin and improve cosmetic aspects, while making negligible the

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Section: Topical Photochemotherapy: Bath-puvasupporting

confidence: 62%

Effectiveness and Safety of Topical Phototherapy in the Treatment of Dermatological Diseases

Delrosso¹,

Savoia²

2017

Photomedicine - Advances in Clinical Practice

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“…We have previously described the appearance of these lesions following phototherapy. 20 Therefore, we suggest that patients with MF may be prone to pigmentary disorders in response to phototherapy, either in the form of lentigines or in the form of IGH-like lesions.…”

Section: Discussionmentioning

confidence: 94%

NB‐UVB (311–312 nm)‐induced lentigines in patients with mycosis fungoides: a new adverse effect of phototherapy

Friedland¹,

David

Feinmesser

et al. 2011

Acad Dermatol Venereol

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“…Con la luz se puede presentar fototoxicidad, alteraciones oculares, prurito, alteraciones de la pigmentación (22), fotoenvejecimiento o fotocarcinogénesis (11,18). Con los psoralenos se pueden presentar náuseas, vómitos y cefalea (23).…”

Section: Efectos Secundariosunclassified

“…Los eventos secundarios asociados a la NB-UVB son eritema, ampollas, xerosis, prurito, reactivación de herpes simple, fotoenvejecimiento, fotocarcinogénesis, queratitis, conjuntivitis, alteraciones de la pigmentación y léntigos (11,22,23).…”

Section: Efectos Secundariosunclassified

Cuándo emplear PUVA o NB-UVB en micosis fungoide

Roldán

Jiménez²

2016

CES Med

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ResumenLa micosis fungoide es un linfoma cutáneo de células T de etiología desconocida que afecta principalmente a la población adulta. En sus fases iniciales la fototerapia sigue siendo una de las principales opciones terapéuticas. La terapia con NB-UVB en estadios tempranos IA-IB en parches y placas delgadas ofrece ventajas sobre el PUVA, debido a su mejor tolerancia y menores efectos secundarios; la terapia PUVA sigue siendo la elección en micosis fungoide en placas de mayor grosor. En cuanto a la terapia de mantenimiento se plantea que podría estar asociada a mayor radiación acumulada, sin lograr prevenir futuras lesiones, siendo el antecedente de recaída el principal factor predisponente para presentar nuevas lesiones en el futuro.Palabras clave: Micosis fungoide, Fototerapia, PUVA, UVB, Tratamiento de la micosis fungoide. AbstractMycosis fungoides (MF) is a cutaneous T-cell lymphoma of unknown etiology that primarily affects the adult population. In early stages of the disease phototherapy is a major therapeutic option. At the time NB-UVB therapy in early stages IA-IB patchy and thin plaques offers advantages over PUVA, due to its better tolerance and fewer side effects, the PUVA therapy remains the choice to MF in thinner plaques. The maintenance therapy is posed that could be associated with higher accumulation of radiation without achieving prevents future lesions, being the history of relapse the main predisposing factor to present new lesions in the future.

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Idiopathic guttate hypomelanosis‐like lesions in patients with mycosis fungoides: a new adverse effect of phototherapy

Cited by 17 publications

References 23 publications

Effectiveness and Safety of Topical Phototherapy in the Treatment of Dermatological Diseases

Effectiveness and Safety of Topical Phototherapy in the Treatment of Dermatological Diseases

NB‐UVB (311–312 nm)‐induced lentigines in patients with mycosis fungoides: a new adverse effect of phototherapy

Cuándo emplear PUVA o NB-UVB en micosis fungoide

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