Idiopathic granulomatous mastitis masquerading as carcinoma of the breast: a case report and review of the literature

Tuli, Richard; O’Hara, Brian J.; Hines, J. Peyton; Rosenberg, Anne

doi:10.1186/1477-7800-4-21

Cited by 55 publications

(70 citation statements)

References 17 publications

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“…Bazen malignite benzeri klinik ve radyolojik bulgularla seyreden hastalığa şüpheli ince iğne aspirasyon biyopsisi sonuçları da eklenebilir. Literatürde bu şekilde gereksiz mastektomi yapı-lan İLGM olguları bildirilmiştir (11)(12)(13)(14). Bu durum meme karsinomu şüphelenilen hastalarda histopatolojik incelemenin önemini daha fazla arttırmaktadır.…”

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“…Bazen lezyonların etrafında psödokapsül oluşur. İnflamatuar proçes lobüler üniti destrükte ederek duktus boyunca ilerleyip duktus epitelinde ülserasyon ve yangısal hasara yol açabilir (8,(11)(12)(13)(14). Bu yazıda sunduğumuz 3. olgumuzda makroskopik olarak duktusa benzeyen tubuler uzantı halinde meme başına uzanım göste-ren inflamatuar intraduktal lezyon görülmektedir.…”

Section: Olguunclassified

“…İdyopatik lobüler granülomatöz mastitin US ve mammografik görü-nümleriyle ilgili yayın sayısı oldukça fazladır (3,4,14,16,17). Meme dokusu mammografiyi yorumlamak için yeterince lipomatö özelliktey-se lezyonlar, keskin sınırlı, bazen konturları spikülasyon gösteren kitleler halinde izlenebilirler.…”

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Idiopathic Lobular Granulomatous Mastitis Mimicking Malignancy with Clinical-Radiological Findings: Assessment of Three Cases

Solak¹,

Karaaslan²,

Genç³

et al. 2013

J Breasth Health

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Idiopathic lobular granulomatous mastitis (ILGM) is a relatively rare disease in women during reproductive life and may commonly mimic carcinoma. Histopathology is the most definitive method of diagnosis. Herein, we report three cases who had very similar clinical-radiological findings to malignancy. None of the women has systemic disorder or history of a specific infection. All lesions were widely excised. Histopathological investigation revealed a lobular, non-caseating granulomatous inflammation. Clinicians should consider the possibility of idiopathic granulomatous mastitis in young women with clinical and radiological findings which are similar to malignancy of breast lesions.

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Idiopathic Lobular Granulomatous Mastitis Mimicking Malignancy with Clinical-Radiological Findings: Assessment of Three Cases

Solak¹,

Karaaslan²,

Genç³

et al. 2013

J Breasth Health

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“…Desde el informe de Kessler y Wolloch se han publicado más de 100 casos, la mayoría de ellos en mujeres de raza no caucásica (2) . El diagnóstico presuntivo, en algunos casos, fue de mastitis y, en otros, de cáncer mamario que condujo a la ablación innecesaria de la glándula mamaria (3) .…”

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Mastitis crónica granulomatosa idiopática: reporte de un caso

Takano

Prialé

2010

Rev Peru Med Exp Salud Publica

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RESUMENLa mastitis cónica granulomatosa idiopática es una enfermedad rara que se presenta en mujeres, preferentemente en edad reproductiva, con características clínicas, mamográficas, ecográficas y citológicas sugestivas de cáncer mamario. Se informa un caso de patología mamaria en paciente mujer de 35 años de edad, portadora de tumoración eritematosa, sensible, localizada en mama izquierda. La lesión fue tratada como "mastitis" con antibióticos y corticoides durante dos semanas. La persistencia de tumoración y sensibilidad, así como los controles mamográficos y ecográficos sugestivos de neoplasia, decidieron la extirpación quirúrgica. El diagnóstico histopatológico fue de mastitis crónica granulomatosa idiopática. Palabras clave: Mastitis; Enfermedades de la mama; Enfermedades raras (fuente: DeCS BIREME). IDIOPATHIC CHRONIC GRANULOMATOUS MASTITIS: A CASE REPORT ABSTRACTIdiopathic chronic granulomatous mastitis is a rare disease in women at the reproductive life with clinic, mammographic, echographic and cytological characteristics suggestive of breast cancer. We report a case of breast pathology in a 35 years old woman who had a sensitiveness and eritematous tumor localized in the left breast. With the diagnosis of "mastitis", she was treated with antibiotics and corticoids for two weeks. Because the lesion and the sensitiveness persist and the mammographic and ecographic controls were suggestive of malignancy, the tumor was surgically removing. The histopathological diagnosis was idiopatic chronic granulomatous mastitis.

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“…Although several studies have reported different approaches for the management of IGM, many of these treatment algorithms were formulated without a definitive initial diagnosis. 15 The treatment plan for IGM followed at most centres is to perform a complete resection or an open biopsy with corticosteroid therapy. 16 However, surgery can be complicated by abscess formation, fistulas, scarring and chronic suppuration.…”

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Idiopathic Granulomatous Mastitis : Diagnostic Strategy and Therapeutic Implications in Omani Patients = إلتهاب الثدي الحبيبي : خطط التشخيص و التطبيقات العلاجية للمرضى العمانيين

Aljarrah¹,

Taranikanti²,

Lakhtakia³

et al. 2013

SQUMJ

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abstract:Objectives: Idiopathic granulomatous mastitis (IGM) is a rare benign disorder of the breast whose aetiology is controversial, and is often misdiagnosed clinically and radiologically as mammary malignancy; as a result, it may be incorrectly treated. Although no standard treatment is available for this chronic disease, surgery with or without corticosteroids has been tried with controversial results. This study discusses the clinical presentation, diagnosis, management, recurrence, and follow-up data of IGM with a review of relevant literature. Methods: From 2009-2012, the Breast Unit at Sultan Qaboos University Hospital, Oman, conducted a clinical study on 20 patients with breast lumps. Their clinical and radiological examinations were indeterminate, and a diagnosis of granulomatous mastitis was established only by histopathology. Results: The majority of the patients were cases of unknown aetiology, who presented with a unilateral breast mass. A few patients had a mass with an abscess, along with axillary lymphadenopathy. A total of 4 patients were suspected of malignancy using radiology. In all patients, sterilised pus was sent for culture and sensitivity. Microscopy showed the characteristic pattern of granulomatous inflammation. All patients were treated with antibiotics for 6 weeks, and the mean follow-up period was 15 months (11-33 months). All patients had complete remission with no further recurrence. Conclusion: This single largest study of cases of IGM in Oman highlights the pitfalls in diagnosing this non-neoplastic disease of unknown aetiology and uncertain pathogenesis. It emphasises IGM's excellent response to antibiotics, which is crucial, as IGM is a disease which is notoriously difficult and controversial to treat.

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Idiopathic granulomatous mastitis masquerading as carcinoma of the breast: a case report and review of the literature

Cited by 55 publications

References 17 publications

Idiopathic Lobular Granulomatous Mastitis Mimicking Malignancy with Clinical-Radiological Findings: Assessment of Three Cases

Idiopathic Lobular Granulomatous Mastitis Mimicking Malignancy with Clinical-Radiological Findings: Assessment of Three Cases

Mastitis crónica granulomatosa idiopática: reporte de un caso

Idiopathic Granulomatous Mastitis : Diagnostic Strategy and Therapeutic Implications in Omani Patients = إلتهاب الثدي الحبيبي : خطط التشخيص و التطبيقات العلاجية للمرضى العمانيين

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