Idiopathic Granulomatous Mastitis: Etiopathogenetic Considerations on a Rare Benign Inflammatory Breast Disease

Altieri, Michele; Barra, Fabio; Casabona, Federico; Soriero, Domenico; Gustavino, Claudio; Ferrero, Simone

doi:10.1080/08941939.2020.1742403

Cited by 10 publications

(7 citation statements)

References 8 publications

(8 reference statements)

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“…Idiopathic granulomatous mastitis is an increasingly recognized, albeit rare, entity that can mimic breast malignancies and abscesses 1 . The pathogenesis is poorly understood, currently conceptualized as an autoimmune reaction to milk proteins within interstitial breast tissue 2 . Supporting this hypothesis, it presents as a mass with variable pain, erythema or discharge, typically in women of child‐bearing age who have a recent history of pregnancy and lactation 1,3,4 .…”

Section: Figurementioning

confidence: 99%

“…1 The pathogenesis is poorly understood, currently conceptualized as an autoimmune reaction to milk proteins within interstitial breast tissue. 2 Supporting this hypothesis, it presents as a mass with variable pain, erythema or discharge, typically in women of child-bearing age who have a recent history of pregnancy and lactation. 1,3,4 The histologic pattern of lobulocentric granulomatous inflammation can also be observed in malignancies, infections and autoimmune conditions.…”

mentioning

confidence: 97%

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Granulomatosis with polyangiitis: a life‐threatening cause of granulomatous mastitis

Koch

Lamont

2020

ANZ Journal of Surgery

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Section: Figurementioning

confidence: 99%

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confidence: 97%

Granulomatosis with polyangiitis: a life‐threatening cause of granulomatous mastitis

Koch

Lamont

2020

ANZ Journal of Surgery

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“…Generally, non-lactating mastitis (NLM) mainly includes plasma cell mastitis (PCM) ( 1 ) and granulomatous mastitis (GM) ( 2 ). It is a kind of inflammatory breast disease that occurs among the non-lactating women with the ages ranging between 30 and 40 years old ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

Differentiating non-lactating mastitis and malignant breast tumors by deep-learning based AI automatic classification system: A preliminary study

Zhou¹,

Feng²,

Yue³

et al. 2022

Front. Oncol.

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Objective: To explore the application values of deep-learning based artificial intelligence (AI) automatic classification system, on the differential diagnosis of non-lactating mastitis (NLM) and malignant breast tumors, via its comparation with traditional ultrasound interpretations and the following interpretation conclusions made by the sonographers with various seniorities.Methods: A total of 707 patients suffering from breast lesions (475 malignant breast tumors and 232 NLM), were selected from the following three medical centers, including

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“…Its etiology, like that of IGM treatment, is unknown, but it is generally thought to be idiopathic. However, some etiological causes have been proposed, including autoimmune diseases, hormonal imbalances, various infections, breast trauma, smoking, and genetic factors [ 19 20 21 ].…”

Section: Introductionmentioning

confidence: 99%

Plastic and reconstructive breast surgery techniques in the surgical treatment of idiopathic granulomatous mastitis: a single-center experience

Dokcu

Başçeken

2022

Ann Surg Treat Res

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Purpose Idiopathic granulomatous mastitis (IGM) is a chronic inflammatory breast disease with unknown cause and undefined treatment. Since it has a high recurrence rate, wide excisions are recommended for surgical treatment. This study aims to discuss the selection and outcomes of plastic and reconstructive breast surgery techniques following wide excision. Methods This study examines the prospectively recorded surgical outcomes of 18 patients who were diagnosed with IGM between 2020 and 2022. Following histopathological confirmation of all patients’ diagnoses, the most appropriate technique was used in conjunction with wide surgical excision. Preoperative standing drawings were made for all patients and operations were performed by the same surgical team under general anesthesia. All patients were monitored for 6 months for postoperative complications, recurrence, and aesthetic outcomes. Results The patients underwent surgery for recurrence (n = 8), recurrent abscess (n = 4), and persistent disease (n = 6), in that order. Patients were treated with dermoglandular flap transposition (n = 6), Wise pattern reduction mammoplasty (n = 3), vertical reduction skin incision (n = 3), inferior pedicle with Wise pattern reduction mammoplasty (n = 4), and free nipple reduction mammoplasty (n = 2) techniques following partial mastectomy. No major complications developed postoperatively. Two patients with recurrence benefited from topical steroid injections. Conclusion A wide excision is required to prevent IGM recurrence during surgery. After wide excision, the simplest and most easily applicable plastic and reconstructive breast surgery techniques can yield successful results with acceptable complication and recurrence rates. In technique selection, we recommend an individualized surgical approach for effective patient management.

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Idiopathic Granulomatous Mastitis: Etiopathogenetic Considerations on a Rare Benign Inflammatory Breast Disease

Cited by 10 publications

References 8 publications

Granulomatosis with polyangiitis: a life‐threatening cause of granulomatous mastitis

Granulomatosis with polyangiitis: a life‐threatening cause of granulomatous mastitis

Differentiating non-lactating mastitis and malignant breast tumors by deep-learning based AI automatic classification system: A preliminary study

Plastic and reconstructive breast surgery techniques in the surgical treatment of idiopathic granulomatous mastitis: a single-center experience

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