Idiopathic granulomatous mastitis: a 10-year study from a multicentre clinical database

Co, Michael; Cheng, Vincent Chi-Chung; Wei, Jiannan; Wong, Sally Cheuk Ying; Chan, Sally M.S.; Shek, Tony W. H.; Kwong, Ava

doi:10.1016/j.pathol.2018.08.010

Cited by 77 publications

(71 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The presence of epithelioid histiocytes and multinucleated giant cells on a ground dominated by lobular noncaseating granulomas, neutrophils, plasma cells, and eosinophils confirms the diagnosis of lobular granulomatous mastitis. 4 However, histopathological findings are not pathognomonic for IGM. 5 Mycobacterium tuberculosis, Corynebacterium and fungal infections, sarcoidosis, autoimmune disease (ie, Wegener granulomatosis, giant cell arteritis), and foreign body reactions should be excluded during work-up.…”

Section: Introductionmentioning

confidence: 99%

Idiopathic granulomatous mastitis with erythema nodosum: Is it a variant of clinical presentation indicating treatment resistance? A retrospective cohort study

2020

View full text Add to dashboard Cite

Idiopathic granulomatous mastitis (IGM) rarely occurs with erythema nodosum (EN) as a systemic finding. However, the impact of their coexistence on disease severity and response to steroids has not been investigated yet. Patients diagnosed with IGM between September 2014 and October 2018 were divided into two groups according to the presence or absence of EN during the first admission retrospectively. The IGM was more severe in patients with EN as it was presented more often as bilateral and diffuse involvement of the breast. Findings of mastitis did not resolve with steroids in 50% of this group. Repetitive excisions and mastectomy with reconstructions were required to control the disease. Coexistence of EN and IGM was found to be related to bilateral and aggressive involvement, which could be associated with insufficient response to steroids. Associated patients should be informed in terms of the aggressive course, and surgery can be highlighted as a first-line treatment.

show abstract

Section: Introductionmentioning

confidence: 99%

Idiopathic granulomatous mastitis with erythema nodosum: Is it a variant of clinical presentation indicating treatment resistance? A retrospective cohort study

2020

View full text Add to dashboard Cite

show abstract

“…[5]. In addition, granulomatous mastitis might be associated with different Corynebacterium species [6].…”

Section: Introductionmentioning

confidence: 99%

Risk of Breast Cancer in Women with Mastitis: A Retrospective Population-Based Cohort Study

et al. 2020

View full text Add to dashboard Cite

Background and objectives: Breast cancer is a common cancer in women and has been the fourth leading cause of death in Taiwanese women. Risk factors for breast cancer include family history of breast cancer, genetic factors, and not breastfeeding. Several studies have reported an association between repeated inflammation at a young age, especially among lactating women, and cancer; however, the number of studies about the association of mastitis and breast cancer in nonlactating women is still limited. Therefore, the aim of this study was to determine the relationship between mastitis in women aged ≥40 years and breast cancer. Materials and Methods: This was a retrospective cohort study design. The data source was the Longitudinal Health Insurance Database 2010 (LHID 2010), comprising data collected by Taiwan’s National Health Insurance program. Cases of newly diagnosed mastitis in women aged ≥40 years (ICD-9-CM code = 611.0) were selected from the years 2010 to 2012. Women not diagnosed with mastitis were selected as the control group, and their data for the years 2009 to 2013 were obtained through the database. In addition, the non-mastitis group was matched 1:10 by age. Results: A total of 8634 participants were selected from the LHID 2010, which included 734 cases with mastitis and 7900 cases without mastitis. After adjustment for age, hypertension, hyperlipidemia, diabetes, hypothyroidism, and autoimmune diseases, the Cox proportional hazard model showed that patients with mastitis had a higher risk of breast cancer (aHR = 3.71, 95% CI = 1.9–7.02) compared with the non-mastitis group. The Kaplan–Meier curve also showed that women with mastitis had a higher risk of developing breast cancer. Conclusions: This study confirmed that women with mastitis have a higher risk of developing breast cancer. Therefore, women aged ≥40 years could reduce breast cancer risk by taking precautions to prevent mammary gland infection and mastitis.

show abstract

“…It should be noted that most of the published case series of IdGM concern patients from countries where tuberculosis has a high prevalence rate [148]. Corynebacterium kroppenstedtii has also been involved in the pathophysiology of IdGM and in its recurrence [145]. These points are consistent with the role of potential infectious agents that are involved in the pathophysiology of IdGM.…”

Section: Granulomatous Mastitis Associated With Other Autoimmune Disementioning

confidence: 56%

“…As suggested by its name, the etiologies of "idiopathic" granulomatous mastitis are not clearly identified: both endogenous and exogenous factors are involved. Among the exogenous factors, tobacco use has been incriminated [145] and, likewise, infectious agents. Indeed, Helal and coll.…”

Section: Granulomatous Mastitis Associated With Other Autoimmune Disementioning

confidence: 99%

Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players

Goulabchand

Hafidi

Perre

et al. 2020

JCM

View full text Add to dashboard Cite

Mastitis frequently affects women of childbearing age. Of all the pathological breast conditions requiring specific management, autoimmune mastitis is in the third position after infection and breast cancer. The aim of this literature review was to make a comprehensive description of autoimmune diseases targeting the mammary gland. Four main histological patterns of autoimmune mastitis are described: (i) lymphocytic infiltrates; (ii) ductal ectasia; (iii) granulomatous mastitis; and (iv) vasculitis. Our literature search found that all types of autoimmune disease may target the mammary gland: organ-specific diseases (diabetes, thyroiditis); connective tissue diseases (such as systemic erythematosus lupus or Sjögren’s syndrome); vasculitides (granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, giant cell arteritis, polyarteritis nodosa, Behçet’s disease); granulomatous diseases (sarcoidosis, Crohn’s disease); and IgG4-related disease. Cases of breast-specific autoimmune diseases have also been reported, including idiopathic granulomatous mastitis. These breast-limited inflammatory diseases are sometimes the first symptom of a systemic autoimmune disease. Although autoimmune mastitis is rare, it is probably underdiagnosed or misdiagnosed. Early diagnosis may allow us to detect systemic diseases at an earlier stage, which could help to initiate a prompt, appropriate therapeutic strategy. In case of suspected autoimmune mastitis, we hereby propose a diagnostic pathway and discuss the potential pathophysiological pathways leading to autoimmune breast damage.

show abstract

Idiopathic granulomatous mastitis: a 10-year study from a multicentre clinical database

Cited by 77 publications

References 29 publications

Idiopathic granulomatous mastitis with erythema nodosum: Is it a variant of clinical presentation indicating treatment resistance? A retrospective cohort study

Idiopathic granulomatous mastitis with erythema nodosum: Is it a variant of clinical presentation indicating treatment resistance? A retrospective cohort study

Risk of Breast Cancer in Women with Mastitis: A Retrospective Population-Based Cohort Study

Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players

Contact Info

Product

Resources

About