1994
DOI: 10.1056/nejm199412083312307
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Idiopathic Dilated Cardiomyopathy

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Cited by 850 publications
(491 citation statements)
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References 135 publications
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“…The clinical manifestation varies, including dyspnea, exertional intolerance, or a consequence of ventricular dysfunction and heart failure. Growing evidence has directed the clinical significance to the prevention of sudden cardiac death (SCD) in NICM patients, which is usually attributed to ventricular tachyarrhythmias arising from a diseased ventricular substrate 2, 3, 4. Therefore, in the risk stratification of NICM patients, given the potential specific therapies and risk prevention strategies for the nonuniform entities of NICM, the identification of the underlying pathogenesis is of clinical relevance.…”
Section: Introductionmentioning
confidence: 99%
“…The clinical manifestation varies, including dyspnea, exertional intolerance, or a consequence of ventricular dysfunction and heart failure. Growing evidence has directed the clinical significance to the prevention of sudden cardiac death (SCD) in NICM patients, which is usually attributed to ventricular tachyarrhythmias arising from a diseased ventricular substrate 2, 3, 4. Therefore, in the risk stratification of NICM patients, given the potential specific therapies and risk prevention strategies for the nonuniform entities of NICM, the identification of the underlying pathogenesis is of clinical relevance.…”
Section: Introductionmentioning
confidence: 99%
“…In 2013, CMS enforced the “2 midnights” rule, which meant that a patient had to stay at least 2 consecutive midnights at the hospital to count as an inpatient admission; otherwise, it would be counted as an admission OBS 4. This had significant implications on both hospitals and patients.…”
Section: Introductionmentioning
confidence: 99%
“…Mutations in genes encoding myocyte structural proteins are found in about 30-40% of DCM, but the etiology of the remaining 60-70% of cases is poorly understood [1][2][3]. Advances in the field of immunology have shed light on the close relationship between immunological disturbances and the progression of heart failure [4][5][6][7].…”
Section: Introductionmentioning
confidence: 99%