Idiopathic Choroidal Neovascularization as an Early Manifestation of Inflammatory Chorioretinal Diseases

Machida, Shigeki; Fujiwara, Tetsuro; Murai, Kazuo; Kubo, Masabumi; Kurosaka, Daijiro

doi:10.1097/iae.0b013e318160798f

Cited by 40 publications

(26 citation statements)

References 26 publications

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“…1,2 Type 2 neovascularization is associated with conditions such as age-related macular degeneration, myopic macular degeneration, angioid streaks, and punctate inflammatory choroidopathy (PIC)/multifocal choroiditis (MFC). [3][4][5][6] In young myopic patients, it is sometimes difficult to distinguish inflammatory choroidal neovascularization (CNV) from idiopathic or myopic CNV. We have identified a distinctive optical coherence tomography (OCT) finding that may help distinguish inflammatory CNV from the other causes of subneurosensory neovascularization.…”

mentioning

confidence: 99%

THE “PITCHFORK SIGN” A Distinctive Optical Coherence Tomography Finding in Inflammatory Choroidal Neovascularization

Hoang

Cunningham

Sorenson

et al. 2013

Retina

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confidence: 99%

THE “PITCHFORK SIGN” A Distinctive Optical Coherence Tomography Finding in Inflammatory Choroidal Neovascularization

Hoang

Cunningham

Sorenson

et al. 2013

Retina

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“…In this study, 43.9% of patients had ICNV, and 63.6% of them were female. Although it is not known why more female patients had ICNV, a study reported that ICNV is an early stage of inflammatory chorioretinal diseases, such as PIC, MCP, and MEWDS [19], which might partially explain the phenomenon. Moreover, there were only 4 patients (1.8%) with bilateral ICNV in this study, which indicated that patients with ICNV usually had unilateral CNV, and they appeared to have a low risk of developing CNV in their other eye [3].…”

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confidence: 99%

Etiologies and Characteristics of Choroidal Neovascularization in Young Chinese Patients

et al. 2018

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Purpose: To investigate the etiologies and characteristics of choroidal neovascularization (CNV) in young Chinese patients. Methods: A retrospective review of young Chinese patients (< 50 years of age) with CNV from January 2010 to June 2016 was performed. Results: Of the 501 patients (537 eyes) with CNV, 58.7% were female, and 7.2% had bilateral CNV. The mean age was 35 years. The etiologies were idiopathic CNV (ICNV, 43.9%), pathologic myopia (PM, 21.9%), punctate inner choroidopathy (PIC, 17.4%), polypoidal choroidal vasculopathy (4.4%), multifocal choroiditis with panuveitis (3.6%), and other disorders (8.8%). Five hundred and six CNVs (94.2%) showed a predominantly classic CNV composition on fundus fluorescein angiography (FFA) and 316 CNVs (96.6%) were type 2 CNV on optical coherence tomography (OCT). Conclusion: The etiologies of CNV in young Chinese patients were diverse, and ICNV, PM, and PIC were the three most common etiologies. Most CNVs were classic on FFA and type 2 on OCT.

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“…[4][5][6][7][8][9][10][11] Olguların yaklaşık olarak %50'sinde vitreusta hücre olabileceği ancak ön kamarada hücrenin genellikle olmadığı bilinmektedir. 3 Bu olguda ise önce ön kamara hücrelerinin hemen sonrasında da vitreus hücre-leri ve tipik retina lezyonlarının ortaya çıktığı atipik başlangıçlı bir multipl geçici beyaz nokta sendromu olgusu sunulmaktadır.…”

Section: Discussionunclassified

“…Literatürde ileri yaş başlangıçlı, bilateral, tekrarlayıcı, koroid neovasküler membran oluşu-muna neden olan, multifokal koroidit veya akut idiyopatik kör nokta genişlemesi sendromu ile birlikte ortaya çıkan ve karakteristik beyaz noktaların görülmediği atipik olgular sunulmuştur. [4][5][6][7][8][9][10] Çalışmamızda, prodromal dönemde ön üveit tanısı konulup takibinde multipl geçici beyaz nokta sendromu bulguları ortaya çıkan atipik başlangıçlı bir olgu sunulmuştur.…”

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Multiple Evanescent White Dot Syndrome with an Atypical Presentation: Case Report

Şekeroğlu¹,

Üzel²,

Anayol³

et al. 2015

Turkiye Klinikleri J Ophthalmol

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182lk kez 1984 yılında tanımlanan ve nadir görülen bir hastalık olan multipl geçici beyaz nokta sendromu, retinanın dış tabakalarında veya retina pigment epiteli seviyesindeki gri-beyaz lezyonlarla karakterize, nedeni tam olarak bilinmeyen ve genellikle tedavi edilmeksizin kendiliğinden düzelen bir hastalıktır.1,2 Hastaların çoğunda bulgular ortaya çık-madan hemen önce prodromal bir üst solunum yolu enfeksiyonu öyküsü olması, viral bir etiyolojiyi düşündürmektedir.Tipik olarak sağlıklı genç kadınlarda tek taraflı görme azalması ile ortaya çıkar. Hastalık tanısını koymaya yardımcı olan retina bulguları arka kutupta ve mid-periferde yer alan 100-200 µm büyüklüğündeki gri-beyaz lezyonlar Atipik Başlangıçlı Multipl Geçici Beyaz Nokta Sendromu Ö ÖZ ZE ET T Sağlıklı genç kadınlarda tek taraflı görme azalması ile ortaya çıkan multipl geçici beyaz nokta sendromu, tipik olarak retinanın dış tabakalarında veya retina pigment epiteli seviyesindeki gribeyaz lezyonlarla ve foveadaki granüler görünümle karakterizedir. Genellikle sistemik bir hastalık tabloya eşlik etmemektedir. Nedeni tam olarak bilinmeyen ve nadir görülen bu hastalık çoğunlukla tedavi edilmeksizin kendiliğinden düzelir. Ön segment muayenesi genellikle normal olmakla birlikte, olguların yaklaşık yarısında vitreus tutulumu görülebilir. Bu olguda, prodromal dönemde ön üveit bulguları ile ortaya çıkan atipik başlangıçlı bir multipl geçici beyaz nokta sendromu hastası-nın bir yıllık izlemi ile birlikte hastalığın tipik fundus otofloresans görüntüleme ve optik koherens tomografi bulguları sunulmuştur.A An na ah ht ta ar r K Ke el li im me el le er r: : Üveit, anterior; tomografi, optik koherens A AB BS ST TR RA AC CT T Multiple evanescent white dot syndrome is a rare disorder of young healthy female subjects presented with unilateral vision loss and can be diagnosed with foveal granularity and typical gray-white retinal lesions at the outer retina and retinal pigment epithelium. It is a self limiting disease without a need for treatment, but the exact cause is unknown. There is no defined association with systemic disorders. Vitritis can be seen in half of the cases but anterior segment examination is usually normal. Herein, we report one-year follow-up outcomes of a patient with multiple evanescent white dot syndrome who atypically presented with anterior uveitis at prodromal period and also presented its typical fundus autofluorescence and optical coherence tomography findings.

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Idiopathic Choroidal Neovascularization as an Early Manifestation of Inflammatory Chorioretinal Diseases

Abstract: These findings suggest that ICNV can be an early manifestation of inflammatory chorioretinal diseases, including MEWDS, MFC, and PIC.

Cited by 40 publications

References 26 publications

THE “PITCHFORK SIGN” A Distinctive Optical Coherence Tomography Finding in Inflammatory Choroidal Neovascularization

THE “PITCHFORK SIGN” A Distinctive Optical Coherence Tomography Finding in Inflammatory Choroidal Neovascularization

Etiologies and Characteristics of Choroidal Neovascularization in Young Chinese Patients

Multiple Evanescent White Dot Syndrome with an Atypical Presentation: Case Report

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