Abstract:C entral diabetes insipidus (CDI) is a heterogeneous hypothalamus-pituitary disease due to the deficiency of arginine vasopressin (AVP), and is characterized by polyuria and polydipsia. CDI is caused by the destruction or degeneration of the AVP-secreting magnocellular neurons in the hypothalamic supraoptic and paraventricular nuclei. The etiology of CDI can be familial or secondary to malformations, autoimmune, infiltrative (e.g. neoplastic or histiocytsis) or traumatic processes (1). Genetic defects in the s… Show more
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