Idiopathic CD4+ T-cell Lymphocytopaenia Associated with Recalcitrant Viral Warts and Squamous Malignancy

Ladoyanni, Evmorfia; North, Jonathan; Tan, Chin Yao

doi:10.2340/00015555-0150

Cited by 13 publications

(7 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…49 Premalignant lesions (vulval intraepithelial neoplasia, Bowen disease) and malignancies (e.g., Kaposi sarcoma, 61 squamous cells carcinoma and basal cell carcinoma) have been reported. 60,61,81 Signs of autoimmune disease (e.g. dermatomyositis, 82 vitiligo, 83 and psoriasis 84 ) have been described.…”

Section: Infectionsmentioning

confidence: 99%

“…67 In cutaneous malignancy, especially HPVassociated, recurrence and dissemination have been commonly reported. 8,81 Autoimmune conditions are also treated as per standard protocols using steroids and other immunomodulators. This added immunosuppression may precipitate opportunistic infections in patients with ICL and so close follow up is necessary.…”

Section: Therapy Of Presenting Illnessmentioning

confidence: 99%

See 1 more Smart Citation

<p>Idiopathic CD4 Lymphocytopenia: Current Insights</p>

Vijayakumar¹,

Viswanathan²,

Aghoram³

2020

ITT

View full text Add to dashboard Cite

Idiopathic CD4 lymphocytopenia is a condition characterized by low CD4 counts. It is rare and most of the information about this illness comes from case reports. Presentation is usually in the 4th decade of life with opportunistic infections, autoimmune disease or neoplasia. The pathophysiology of this condition is not well understood. Management revolves around treatment of the presenting condition and close follow-up of these patients. This review presents a narrative summary of the current literature on idiopathic CD4 lymphocytopenia.

show abstract

Section: Infectionsmentioning

confidence: 99%

Section: Therapy Of Presenting Illnessmentioning

confidence: 99%

<p>Idiopathic CD4 Lymphocytopenia: Current Insights</p>

Vijayakumar¹,

Viswanathan²,

Aghoram³

2020

ITT

View full text Add to dashboard Cite

show abstract

“…For example, the presence of a robust T‐cell and macrophage infiltrate correlates with regression in genital warts . Patients who have genetic immune defects in the quantity or quality of their T‐cell repertoire often have susceptibility to viral infections as a distinct feature of their genetic disease . Patients who have Dock8 deficiency or idiopathic T‐cell lymphocytopenia can have extensive cutaneous verrucae.…”

Section: Immunity and Hpvmentioning

confidence: 99%

“…32 Patients who have genetic immune defects in the quantity or quality of their T-cell repertoire often have susceptibility to viral infections as a distinct feature of their genetic disease. [33][34][35] Patients who have Dock8 deficiency or idiopathic T-cell lymphocytopenia can have extensive cutaneous verrucae. The degree of risk that these patients have of developing SCC is not clear, although SCC have been reported in these patients.…”

Section: Immunity and Hpvmentioning

confidence: 99%

Cutaneous Squamous Cell Carcinoma and Human Papillomavirus: Is There an Association?

Aldabagh

Angeles

Cardones

et al. 2013

Dermatologic Surgery

View full text Add to dashboard Cite

Background The role of human papillomavirus (HPV) in the induction and maintenance of cervical, anogenital, and some oropharyngeal carcinomas is well recognized. However, its role in cutaneous squamous cell carcinoma (SCC) remains to be elucidated. HPV is thought to act as a possible co-carcinogen in the development of SCC. Objective To review the literature assessing the correlation and possible causation of HPV and cutaneous SCC in the immunocompetent and immunocompromised populations. Methods We reviewed HPV sampling and detection methods, epidemiologic studies examining HPV carriage in immunocompetent and immunosuppressed individuals, and evidence asserting an association between HPV and cutaneous SCC. Results Although an abundant body of evidence points toward a link between HPV and cutaneous SCC, many studies indicate otherwise. Recent studies have focused on viral activity in addition to DNA presence. Conclusion The possibility exists that HPV may play a role in the induction but not maintenance of cutaneous SCC.

show abstract

“…Transmission of warts occurs from direct person-to-person contact or indirectly by fomites (5) . Cell mediated immunity appears to be the principle mechanism for the rejection of warts (6) . Common warts occur largely between the age of 5and 20years and only 15% occur after the age of 35 (7) .…”

mentioning

confidence: 99%