Idiopathic Calcinosis Cutis in a Child: Chemical Composition of the Calcified Deposits

Niu, Dau‐Ming; Lin, Shan‐Yang; Li, Mei-Jane; Cheng, Wenli; Pan, Chin-Chen; Lin, Chih‐Cheng

doi:10.1159/000327084

Cited by 9 publications

(10 citation statements)

References 38 publications

(33 reference statements)

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“…The combination of techniques has revealed the most specific information on the composition of the deposits . The two major components in human idiopathic CC of subcutaneous tissues are type B carbonated apatite and β‐carotene . In future studies, it may be prudent to perform Raman spectroscopy to determine whether β‐carotene is also a component of CC in canine skin.…”

Section: Discussionmentioning

confidence: 99%

Calcinosis cutis in dogs: histopathological and clinical analysis of 46 cases

Doerr

Outerbridge

White

et al. 2013

Veterinary Dermatology

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Background -Calcinosis cutis is well recognized in dogs with endogenous hyperglucocorticism and iatrogenic hyperglucocorticism, but the pathogenesis is still unclear.Objectives -The objectives of the study were to identify possible correlations between histopathological patterns of dermal mineralization in skin biopsies and underlying causes for calcinosis cutis in dogs, as well as to determine breed predilection and age of onset for dogs within a hospital population. In addition, mineral analysis was performed on four biopsy samples.Animals -Forty-six dogs with histopathologically confirmed calcinosis cutis were evaluated.Methods -Medical records and histological sections of dogs with calcinosis cutis diagnosed by histopathology over a 21 year period were reviewed. Infrared spectrometry was used to identify the mineral in the paraffin blocks. Exact chi-squared test was used to identify breed predispositions, while a Mann-Whitney U-test was used to identify age correlations.Results -Labrador retrievers, Rottweilers, boxers and Staffordshire terriers were the breeds most commonly affected in this study. Most dogs had either an exogenous or an endogenous source of corticosteroids, with the exception of five dogs with renal insufficiency. In the majority of cases, mineralization was found throughout the entire dermis. The average age of onset of calcinosis cutis for dogs with endogenous hyperglucocorticism was older than that of dogs with iatrogenic hyperglucocorticism. Using infrared spectrometry, apatite crystals were found to be the source of mineral.Conclusions and clinical importance -There was no observable difference in the histopathological pattern of calcinosis cutis from dogs with endogenous hyperglucocorticism versus iatrogenic hyperglucocorticism. While glucocorticoid therapy appears to predispose dogs to developing calcinosis cutis, it remains unclear whether there is a specific dose or combination of factors that initiates the mineral deposition. Furthermore, the mineral deposition in dogs with calcinosis cutis was found to be apatite.

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Section: Discussionmentioning

confidence: 99%

Calcinosis cutis in dogs: histopathological and clinical analysis of 46 cases

Doerr

Outerbridge

White

et al. 2013

Veterinary Dermatology

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“…In 2004, Bécuwe et al (2) identified 17 prior cases of MICC, including 13 with Down syndrome, and added one additional patient without. At least four other cases have also been documented (3–6).…”

Section: Discussionmentioning

confidence: 99%

Acral Milia‐Like Idiopathic Calcinosis Cutis in a Child with Down Syndrome: Report of a Case, Review of the Literature, and Description of Dermoscopic Findings

Fox¹,

Mehregan²,

Jablonowski³

2012

Pediatric Dermatology

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Milia-like idiopathic calcinosis cutis (MICC) is a rare dermopathy, usually occurring in children with Down syndrome. We report a case of an 8-year-old girl with Down syndrome who presented with histologically verified MICC, briefly review the literature on MICC, discuss the differential diagnosis, and describe the use of dermoscopy in the evaluation of lesions, which we believe has never been published previously with this entity.

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“…Fourier transform infrared spectroscopy is a measurement technique that can record infrared spectra. This method has been proven to yield rich information about foreign bodies in the skin . In the present case, the FTIR spectra obtained from the splinter‐shaped foreign body showed specific absorption of carbon, oxygen, phosphorus, and calcium, indicating that the material was bone.…”

Section: Discussionmentioning

confidence: 55%

Identification of the cause of severe skin infection by Fournier transform infrared spectroscopy: A case of Fournier's gangrene caused by fish bone

Shimizu

Harada

Akazawa

et al. 2014

The Journal of Dermatology

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Fournier's gangrene (FG) is an infrequent but highly lethal infection. Here we report a 74-year-old man who presented with genital swelling and severe malaise. Based on the physical and imaging examination results, the diagnosis of FG was confirmed. Intraoperative findings showed dirty necrosis of soft tissue, and a splinter-shaped foreign body was found in the perirectal region. The foreign body was thought to be the cause of the condition, and it was analyzed using Fourier transform infrared spectroscopy. We found that the foreign body was a mixture of calcium phosphate and protein, suggesting that the splinter was a bone. Moreover, during the medical interview, the patient mentioned about intake of fish around the time of onset of symptoms. Therefore, to confirm the results of the analysis, DNA was extracted from the foreign body, and genomic PCR with subsequent sequence analysis was performed. The DNA sequence was identical to that of Oncorhynchus kisutch, a salmon that is a very popular food in Japan. On the basis of these findings, we concluded that FG in this case was caused by the penetration into the rectum of an accidentally ingested fish bone. Although some cases of intra-abdominal abscess due to accidental ingestion of fish bone have been reported, FG caused by fish bone is extremely rare.

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Idiopathic Calcinosis Cutis in a Child: Chemical Composition of the Calcified Deposits

Cited by 9 publications

References 38 publications

Calcinosis cutis in dogs: histopathological and clinical analysis of 46 cases

Calcinosis cutis in dogs: histopathological and clinical analysis of 46 cases

Acral Milia‐Like Idiopathic Calcinosis Cutis in a Child with Down Syndrome: Report of a Case, Review of the Literature, and Description of Dermoscopic Findings

Identification of the cause of severe skin infection by Fournier transform infrared spectroscopy: A case of Fournier's gangrene caused by fish bone

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