Idiopathic Aplastic Anemia: An Update

Abstract

Bone marrow failure" encompass all the conditions and syndromes in which there are qualitative or quantitative disorders of one or more lineages (erythroid, myelomonocytic, and/or megakaryocytic). A few years ago, the pathophysiology of these syndromes was completely unknown. Today we have better knowledge for these diseases, allowing the development of new treatment options and the improvement of patients' outcome. Acquired bone marrow failure syndromes include myelodysplastic syndromes, aplastic anemia, paroxysmal nocturnal hemoglobinuria, idiopathic neutropenia and large granular leukemia. All these syndromes share some common features and pathophysiology. The most important feature is the possibility of clonal evolution and progression into acute myelogenous leukemia, and open questions still remain on how to prevent evolution in these patients.

Serum level of interleukin: 8 in correlation with aplastic anemia severity

“…In the present study, as regard to reticulocyte count, There was a significant decrease between studied groups (p< 0.001), also there was a significant decrease between (II & III), (II & IV), (I & III), (I & IV) (p< 0.001) as compared to healthy controls where in group (I), it ranged between 0.1 -0.4 (%) with a mean of 0.263±0.106, in group (II),it ranged between 0.1 -0.4 (%) with a mean of 0.263±0.102, in group (III), it ranged between 0.3 -0.9 (%) with a mean of 0.667±0.225, in group (IV), it ranged between 0.6 -1.9 (%) with a mean of 1.130±0.467, there was non-evident variation between (II & I) and (III & IV) as P-value was (1.000 and 0.655) respectively, which is in agreement with the Mary et al [22] study. This explained by bone marrow ~ 91 ~ hypoplasia [23] . In the present work, the results were supported by Marsh et al [24] observation as they concluded Pancytopenia is commonly seen on a complete blood count (FBC), though lymphocyte counts are generally unaffected.…”

Looking Ahead: Clinical Hematology International Turns One

“…The monthly high-profile webinars are able to reach a very large audience worldwide, and progressively constitute a rich and diversified library of educational material, freely accessible anytime to all. Regional webinars and events in local languages are also being planned (e.g., in French and Spanish) to reach the highest number of colleagues and stakeholders.During its first year of publication, our Clinical Hematology International journal has published high-level clinical reviews and guidelines developed by top experts who thoughtfully analyzed the available research evidence, and provided a comprehensive evaluation, to help advance the field and spread knowledge (e.g., [2][3][4][5][6]). The journal also published original reports, case reports, and a diverse set of material including perspective articles, commentaries, and editorials.The IACH is committed to innovation.…”

“…During its first year of publication, our Clinical Hematology International journal has published high-level clinical reviews and guidelines developed by top experts who thoughtfully analyzed the available research evidence, and provided a comprehensive evaluation, to help advance the field and spread knowledge (e.g., [2][3][4][5][6]). The journal also published original reports, case reports, and a diverse set of material including perspective articles, commentaries, and editorials.…”