Idiopathic Anaphylaxis

Greenberger, Paul A.; Lieberman, Phillip

doi:10.1016/j.jaip.2014.02.012

Cited by 42 publications

(29 citation statements)

References 83 publications

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“…67 An interesting case report 68 addressed the observation that this disorder is associated with having activated B cells. A teenager with highly recalcitrant idiopathic anaphylaxis unresponsive to omalizumab, antihistamines, and steroids was treated successfully with rituximab, suggesting a role in some for IgG antibodies or other mechanisms.…”

Section: Anaphylaxismentioning

confidence: 99%

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2014

Sicherer

Leung

2015

Journal of Allergy and Clinical Immunology

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This review highlights some of the research advances in anaphylaxis; hypersensitivity reactions to foods, drugs, and insects; and allergic skin diseases that were reported in the Journal in 2014. Studies on food allergy suggest worrisomely high rates of peanut allergy and food-induced anaphylaxis-related hospitalizations. Evidence is mounting to support the theory that environmental exposure to peanut, such as in house dust, especially with an impaired skin barrier attributed to atopic dermatitis (AD) and loss of function mutations in the filaggrin gene, is a risk factor for sensitization and allergy. Diagnostic tests are improving, with early studies suggesting the possibility of developing novel cellular tests with increased diagnostic utility. Treatment trials continue to show the promise and limitations of oral immunotherapy, and mechanistic studies are elucidating pathways that might define the degree of efficacy of this treatment. Studies have also provided insights into the prevalence and characteristics of anaphylaxis and insect venom allergy, such as suggesting that baseline platelet-activating factor acetylhydrolase activity levels are related to the severity of reactions. Advances in drug allergy include identification of HLA associations for penicillin allergy and a microRNA biomarker/mechanism for toxic epidermal necrolysis. Research identifying critical events leading to skin barrier dysfunction and the polarized immune pathways that drive AD have led to new therapeutic approaches in the prevention and management of AD.

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Section: Anaphylaxismentioning

confidence: 99%

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2014

Sicherer

Leung

2015

Journal of Allergy and Clinical Immunology

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“…This can help reduce the frequency and severity of episodes [26]. If the flight is longer than 1 week after an episode of idiopathic anaphylaxis, empiric therapy should be initiated and continued to reduce the likelihood of an attack while in flight.…”

Section: Preventionmentioning

confidence: 99%

In-flight allergic emergencies

Sánchez‐Borges

Cardona

Worm

et al. 2017

World Allergy Organization Journal

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Allergic and hypersensitivity reactions such as anaphylaxis and asthma exacerbations may occur during air travel. Although the exact incidence of in-flight asthma and allergic emergencies is not known, we have concerns that this subject has not received the attention it warrants. There is a need to provide passengers at risk and airlines with the necessary measures to prevent and manage these emergencies. A review of the epidemiology, management and approaches to prevention of allergic and asthma emergencies during air travel is presented with the goal of increasing awareness about these important, potentially preventable medical events.

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“…[15][16][17][18][19][20][50][51][52][53][54][55][56] Medication triggers include penicillins, cephalosporins and other antibiotics, NSAIDs such as ibuprofen, and antineoplastic agents. 30 Idiopathic anaphylaxis is uncommon in infants, children and teenagers [15][16][17][18][19][20]71 (see also Idiopathic Anaphylaxis, pages 534 and 535, and Box 58-6). Peri-operative anaphylaxis can be triggered by antibiotics or by neuromuscular blockers/muscle relaxants such as suxamethonium, but any inhaled, injected or topically applied agent can be implicated, including antiseptics such as chlorhexidine.…”

Section: Key Pointsmentioning

confidence: 99%

“…[35][36][37][127][128][129] Physician-monitored incremental food challenge (provocation) tests are sometimes needed to determine the clinical relevance of borderline positive allergen skin tests or absent or low-positive allergen-specific IgE levels in patients who have an equivocal history of anaphylaxis. 71 A positive (failed) challenge provides a sound basis for continued avoidance of the food.…”

Section: Investigations To Confirm the Trigger(s)mentioning

confidence: 99%

Anaphylaxis

Simons¹

2016

Pediatric Allergy: Principles and Practice

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Idiopathic Anaphylaxis

Cited by 42 publications

References 83 publications

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2014

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2014

In-flight allergic emergencies

Anaphylaxis

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