Ideomotor limb apraxia in Huntington's disease

Hödl, Anna K.; Hödl, Elfriede; Otti, Daniela V; Herranhof, Brigitte; Ille, Rottraut; Bonelli, Raphael M.

doi:10.1007/s00415-008-0577-4

Cited by 28 publications

(10 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The high frequency of pantomimic apraxia in HD, observed in our present study and in those by Hodl et al [17] and Hamilton et al [16] , is higher than has been observed previously in several studies of ideomotor limb apraxia in patients with other diseases of the basal ganglia [30][31][32][33][34] . For instance, Leiguarda and Marsen [35] reported pantomimic movement apraxia in 2/8 patients with Parkinson's disease and 2/5 patients with progressive supranuclear palsy.…”

Section: Discussioncontrasting

confidence: 55%

“…In the third study of apraxia in HD by our group, the frequency of apraxia in HD was even higher than in our present study. For instance, Hodl et al [17] observed apraxia in 39.3% of their sample for gestures, 45.8% for hands imitation, 50% for fingers imitation and 67.9% for pantomimic movements.…”

Section: Discussionmentioning

confidence: 99%

“…As mentioned previously, to date, 3 studies have examined the frequency of ideomotor limb apraxia in HD [15][16][17] . In the first study of apraxia in HD by Shelton and Knopman [15] , 33% of the HD group (3/9) and 17% of the AD group (1/6) were classified as apraxic.…”

Section: Discussionmentioning

confidence: 99%

“…The first cases of ideomotor limb apraxia in patients with diseases that were subcortical in origin were reported in the 1980s, when case reports were published on apraxic patients with vascular subcortical dementia, PD and normal-pressure hydrocephalus [13,14] . Similarly, apraxia in HD, where predominantly subcortical structures are damaged, was first identified by Shelton in 1991, after which 2 further similar studies followed [15][16][17] . All of these studies reported a notable frequency of apraxia in HD patients.…”

Section: Introductionmentioning

confidence: 96%

“…A comparison of apraxia in AD and HD patients was reported by Shelton et al, although the sample size in this study was small (AD n = 6, HD n = 11). Shelton and Hamilton did not report about a correlation between stage of disease and apraxia in HD, and Hodl described apraxic HD patients who were in more advanced stages of disease than nonapraxic HD patients [15][16][17] . So, the aims of the present study were to compare the occurrence of apraxia in 2 large groups of AD and HD patients and to analyze if there is a correlation between the stage of disease and occurrence of apraxia, especially in HD patients.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Impaired Ideomotor Limb Apraxia in Cortical and Subcortical Dementia: A Comparison of Alzheimer’s and Huntington’s Disease

Holl¹,

Ille

Wilkinson

et al. 2011

Neurodegener Dis

View full text Add to dashboard Cite

Background: Although ideomotor limb apraxia is often considered to occur only in dementia with cortical involvement like Alzheimer’s disease (AD), it is also frequently seen in dementia with subcortical degeneration like Huntington’s disease (HD). Methods: To assess the occurrence of ideomotor limb apraxia, 46 patients with HD (27 men) and 37 patients with AD (16 men), matched for cognitive performance, were assessed with an apraxia test battery containing tests of the imitation of meaningless hand and finger gestures, the performance of meaningful gestures and of pantomimic movements. Results: There was a high frequency of ideomotor limb apraxia in both AD and HD patients. For the assessment of hands’ imitation 13.5% of the AD patients and 41.3% of the HD patients were apraxic, for fingers’ imitation 21.6% (AD) and 41.3% (HD) were apraxic, for gestures 27.0% (AD) and 32.6% (HD), and for the assessment of pantomimic movements 24.3% (AD) and 52.2% (HD) showed apraxia. In the AD patients, disease severity was related to the occurrence of apraxia. Conclusions: Ideomotor limb apraxia is a common sign in both groups of patients, occurring in a high percentage. For particular neuropsychological deficits, including ideomotor limb apraxia, a division of dementia in a subcortical and cortical subtype seems to be clinically not meaningful.

show abstract