Identity issues surrounding American skullcap (Scutellaria lateriflora) and an optimised high performance liquid chromatography method to authenticate commercially available products

Brock, Christine; Whitehouse, Julie; Tewfik, Ihab; Towell, Tony

doi:10.1016/j.hermed.2013.02.001

Cited by 7 publications

(3 citation statements)

References 18 publications

(34 reference statements)

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“…We therefore conducted High Performance Liquid Chromatography on the batch and a voucher specimen from the American Herbal Pharmacopoeia® to compare phytochemical profiles and to qualify and quantify baicalin, baicalein and wogonin, some of its predominant flavonoids (Upton and Dayu, 2012). The phytochemical profile of the freeze-dried sample was consistent with that of the S. lateriflora reference material and was found to be unadulterated (verbascoside, which is found in Teucrium but not S. lateriflora was not detected) and of suitable quality for the study; containing a high quantity of baicalin (Wohlmuth et al, 2009) at 11.71 ± 1.16 mg/g and 7.67 ± 0.89 mg/g and 0.65 ± 0.06 mg/g of, baicalein and wogonin, respectively (Brock et al, 2013). Freezedried stinging nettle leaf (Urtica dioica folia) capsules (300 mg) was the placebo of choice as it has no known effects on the CNS and is similar in appearance, taste and smell to the skullcap capsules.…”

Section: Participants and Methodssupporting

confidence: 71%

American Skullcap (Scutellaria lateriflora ): A Randomised, Double-Blind Placebo-Controlled Crossover Study of its Effects on Mood in Healthy Volunteers

et al. 2013

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Scutellaria lateriflora, a traditional herbal remedy for stress and anxiety, was tested on human volunteers for its effects on mood. In a placebo-controlled, double-blind, crossover study, 43 healthy participants were randomised to a sequence of three times daily S. lateriflora (350 mg) or placebo, each over two weeks. In this relatively non-anxious population (81% were mildly anxious or less, i.e. Beck Anxiety Inventory (BAI) scores ≤ 15), there was no significant difference between skullcap and placebo with BAI (p = 0.191). However, there was a significant group effect (p = 0.049), suggesting a carryover effect of skullcap. For Total Mood Disturbance measured by the Profile of Mood States, there was a highly significant (p = <0.001) decrease from pre-test scores with skullcap but not placebo (p = 0.072). The limitations of carryover effect, generally low anxiety scores and differences in anxiety levels between groups at baseline (p = 0.022), may have reduced the chances of statistical significance in this study. However, as S. lateriflora significantly enhanced global mood without a reduction in energy or cognition, further study assessing its putative anxiolytic effects in notably anxious subjects with co-morbid depression is warranted.

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Section: Participants and Methodssupporting

confidence: 71%

American Skullcap (Scutellaria lateriflora ): A Randomised, Double-Blind Placebo-Controlled Crossover Study of its Effects on Mood in Healthy Volunteers

et al. 2013

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“…En ambos casos se obtuvieron mayores rendimientos (ácido oleanólico con 11% y ursólico con 47% al utilizar cloroformo, baicalina con 67% y baicaleina con 52 %, al emplear etanol) y se empleó menos tiempo y disolventes que la extracción a reflujo. Sin embargo, en el estudio de algunas escutelarias en los que también se utiliza la extracción asistida por ultrasonido el rendimiento fue inferior (1% con diclorometano a partir de las raíces de S. pinnatifida) (Feyzia et al, 2016) o no se informó (a partir de las partes aéreas de S. laterifolia) (Brock et al, 2013).…”

Section: Resultados Y Discusiónunclassified

“…No obstante, se ha podido verificar que la presencia de wogonina tanto en las diferentes partes de otras escutelarias (S. baicalensis, S. laterifolia, S. barbata, S. litwinowii, S. pinnatifida) como en sus productos comerciales es baja 8.00 10.0012.0014.0016.0018.0020.0022.0024.0026.0028.0030.00 Volumen XIX, Número 3 (0,00 -0,12 %) e inclusive llega a ser nula (Gao et al, 1999;Lai et al, 2001;Malikov and Yuldashev, 2002 ;Makino et al, 2008;Boyle et al, 2011;Mamadalieva et al, 2011;Brock et al, 2013;Tayarani-Najarani et al, 2011;Feyzia et al, 2016). En otras escutelarias como la S. baicalensis los compuestos polifenólicos mayoritarios son la baicaleina y baicalina como se describió anteriormente .…”

Section: Resultados Y Discusiónunclassified

COMPOSICIÓN QUÍMICA DEL EXTRACTO CLOROFÓRMICO DE Scutellaria havanensis JACQ

Delange

Rico

Cuesta³

2017

BIOTECNIA

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El género Scutellaria, que pertenece a la familia Lamiaceae, incluye alrededor de 350 especies. Sus extractos y compuestos, principalmente flavonoides, han mostrado propiedades anti-inflamatorias, ansiolíticas, neuroprotectoras, antitrombóticas, antidiabéticas, anticancerígenas, antioxidantes, antimicrobianas y antivirales. Scutellaria havanensis Jacq., comúnmente llamada Escudo de La Habana, es la única especie de este género que crece en Cuba. Es una hierba perenne y se utiliza en etnomedicina para el tratamiento de la escabiosis, como diaforético y febrífugo. También se cultiva con fines ornamentales. Hasta el presente se han encontrado pocos estudios químicos y farmacológicos acerca de esta planta. Teniendo en cuenta las propiedades farmacológicas reportadas para as diferentes especies de Scutellaria y sus compuestos, se llevó a cabo la caracterización por cromatografía de gases acoplada a espectrometría de masas del extracto clorofórmico de las partes aéreas de S. havanensis. Se encontró que dicho extracto estaba constituido por un 80% de flavonoides, donde la wogonina, dihidrowogonina, baicaleina, 5,2-dihidroxi-6,7,8-trimetoxiflavona y ácido crisofánico, fueron los componentes más abuntantes. Entre ellos, la wogonina fue el componente mayoritario con 48,3%.

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Ethnopharmacological Importance of Western Medicinal Herb, Scutellaria lateriflora

Lohani

Patel

Majrashi

et al. 2016

Medicinal Plants - Recent Advances in Research and Development

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Identity issues surrounding American skullcap (Scutellaria lateriflora) and an optimised high performance liquid chromatography method to authenticate commercially available products

Cited by 7 publications

References 18 publications

American Skullcap (Scutellaria lateriflora ): A Randomised, Double-Blind Placebo-Controlled Crossover Study of its Effects on Mood in Healthy Volunteers

American Skullcap (Scutellaria lateriflora ): A Randomised, Double-Blind Placebo-Controlled Crossover Study of its Effects on Mood in Healthy Volunteers

COMPOSICIÓN QUÍMICA DEL EXTRACTO CLOROFÓRMICO DE Scutellaria havanensis JACQ

Ethnopharmacological Importance of Western Medicinal Herb, Scutellaria lateriflora

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