Identity determination in diagnostic surgical pathology

Pfeifer, John D.

doi:10.1053/j.semdp.2019.06.001

Cited by 3 publications

(5 citation statements)

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“…Molecular profiling is also a useful diagnostic tool, particularly when differential diagnosis between SPMTs and metastasis cannot be confirmed by histomorphology. [30][31][32] We found that nine patients had a family cancer history and three showed a third distinct malignant tumor in this cohort. Wang et al recently reported germline variants of DNA repair genes and of genes involved in B cell functions to be potential causes of MPMTs.…”

Section: Discussionmentioning

confidence: 60%

“…Multidetector CT, 26 PET/CT, 27 PET/MRI, 28 and endoscopy 29 have been reported to be highly efficient at detecting synchronous tumors. Molecular profiling is also a useful diagnostic tool, particularly when differential diagnosis between SPMTs and metastasis cannot be confirmed by histomorphology 30–32 . We found that nine patients had a family cancer history and three showed a third distinct malignant tumor in this cohort.…”

Section: Discussionmentioning

confidence: 65%

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Different situations of identifying second primary malignant tumors in lymphoma patients with synchronous solid tumors

et al. 2023

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Background To our knowledge, the different situations of identifying second primary malignant tumors (SPMTs) in lymphoma patients with synchronous solid tumors remain to be comprehensively investigated. Methods We retrospectively collected information pertaining to lymphoma patients with synchronous solid tumors (diagnosed within 6 months) at Peking University Cancer Hospital & Institute between 2009 and 2019. The non‐parametric Aalen–Johansen estimator was applied to calculate cumulative incidence function in the competing risk model. Furthermore, propensity score‐matched analysis was performed to compare survival differences in lymphoma patients with or without synchronous solid tumors. Results Thirty‐eight patients were enrolled. There were three situations of identifying SPMTs. First, in 15 patients (39.5%), SPMTs were identified before the initiation of any treatment. Among them, priority was given to anti‐lymphoma treatment in case of only three patients. Second, in 17 patients (44.7%), SPMTs were unexpectedly detected on surgical specimen assessment; of them, 13 received anti‐lymphoma treatment after surgery. Third, in six patients (15.8%), SPMTs were identified after the outset of treatment for the primary tumor; in this population, three of four patients with lymphoma switched toward the treatment plan for SPMTs. The 5‐year overall survival was 58.7%. The cumulative incidence function within 5 years was 26.6% for lymphoma and 14.7% for other solid tumors. The early identification of SPMTs was associated with better outcomes (p = 0.048). After balancing the baseline characteristics, no differences in survival were observed between lymphoma patients with and without synchronous solid tumors (p = 0.664). Conclusions This is the first study to present the different situations of identifying SPMTs in lymphoma patients with synchronous solid tumors. In only <50% patients, SPMTs were identifiable at baseline. SPMT identification at different situations may make it difficult to choose the optimal therapeutic option, which may consequently impact patient survival.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 65%

Different situations of identifying second primary malignant tumors in lymphoma patients with synchronous solid tumors

et al. 2023

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“…Better still, the QA&I plan must be woven into all of the other elements of the laboratory to attain the best possible outcomes. 9,10,14,[21][22][23][24][25]…”

Section: Objectives Of Quality Schemes In Histopathology Laboratoriesmentioning

confidence: 99%

“…Rigorous maintenance of the quality or standard is required for a quality laboratory service/product. [18][19][20][21][22] Many terms/concepts centering around the concept of quality, such as total quality management (TQM), QA, QC, etc., are used. Achievement and maintenance quality are the central themes and goals of all of these terms.…”

Section: Introductionmentioning

confidence: 99%