Identity confirmation of 99mTc-MAG3, 99mTc-Sestamibi and 99mTc-ECD using radio-LC-MS

Study of Degradation Products and Degradation Pathways of ECD and Its Drug Product, ECD Kit

“…This is consistent with previous experiment by Verduyckt et al (2003), in which they pointed out the existence of disulfide and incomplete esterification of ethylene dicysteine derivatives. 33, 249.18, 215.27, 208.20, 191.42, 174.15, 146.11, 130.24, 117.11, 102.28, 88.18 ECD was firstly subjected to forced degradation under the conditions of hydrolysis (acid, alkali and neutral), oxidation and thermal stress as requirements of ICH.…”

“…DP#1 and DP#1' were shown to be monoacid monoester degradants of ECD and ECD S-S , whereas DP#2 and DP#2' were diacid degradants of ECD and ECD S-S . These results are consistent with previous study (Verduyckt et al, 2003). The proposed structures of DP#1, DP#1', DP#2 and DP#2' are shown in Fig.…”

“…However, they offered no explanation for the structures of three decomposition products. Verduyckt et al (2003) investigated the identity of Tc-99m-ECD using radio-LC-MS and reported five DPs for ECD including disulfide, monoacid monoester (ECM), diacid (EC) and Sn(IV) complexes with ECD (Sn-ECD) and EC (Sn-EC) derivatives. However, no systematic degradation study was reported to investigate the degradation mechanism or pathway on ECD Kit.…”

Development of 99mTc‐thioflavin‐T derivatives for detection of systemic amyloidosis

“…Small amounts of carrier 99 Tc (about 1.5 mg in the form of NH 4 99 TcO 4 ) were added to the preparation to be able to determine the mass of the selected peaks. [13][14][15][16] Figure 4(A) shows the single ion mass chromatogram of the reaction product after labelling of 2 over the mass range 583.406-583.474 Da and Figure 4(B) the radiometric signal of the radio-LC-MS analysis. The peak at 11.38 min is supposed to be the intended Tc(V)-oxo complex with deprotected 2 ( 99m Tc-2, Scheme 1).…”

Preparo e avaliação de complexos de [99mTc] tecnécio aquacarbonil contendo ligantes 1,2-diaminoetano-N-substituídos para detecção de tumores

“…E ainda assim, artefatos podem ser gerados, pois as condição para a preparação de (A) (B) complexos de tecnécio, para uso em imagem, são diferentes daquelas utilizadas para obtenção dos correspondentes padrões de rênio (48,62) . (48) .…”