Identifying variations in adherence to the CDC sexually transmitted disease treatment guidelines of Neisseria gonorrhoeae

Boyajian, A.J.; Murray, Meghan; Tucker, Max; Neu, Natalie

doi:10.1016/j.puhe.2016.04.004

Cited by 7 publications

(9 citation statements)

References 4 publications

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“…We also assumed complete adherence to the first-line treatment guidelines (determined locally or nationally). While the actual treatment regimens used in the population may differ from the recommended guidelines, recent studies estimate adherence to the CDC guideline for the treatment of gonorrhea to be around 80% [3,24]. We assumed a homogenous risk of infection among the members of the MSM population which does not differ across individuals based on, for example, the number of sexual partners and/or condom use.…”

Section: Discussionmentioning

confidence: 99%

Evaluating spatially adaptive guidelines for the treatment of gonorrhea to reduce the incidence of gonococcal infection and increase the effective lifespan of antibiotics

et al. 2022

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In the absence of point-of-care gonorrhea diagnostics that report antibiotic susceptibility, gonorrhea treatment is empiric and determined by standardized guidelines. These guidelines are informed by estimates of resistance prevalence from national surveillance systems. We examined whether guidelines informed by local, rather than national, surveillance data could reduce the incidence of gonorrhea and increase the effective lifespan of antibiotics used in treatment guidelines. We used a transmission dynamic model of gonorrhea among men who have sex with men (MSM) in 16 U.S. metropolitan areas to determine whether spatially adaptive treatment guidelines based on local estimates of resistance prevalence can extend the effective lifespan of hypothetical antibiotics. The rate of gonorrhea cases in these metropolitan areas was 5,548 cases per 100,000 MSM in 2017. Under the current strategy of updating the treatment guideline when the prevalence of resistance exceeds 5%, we showed that spatially adaptive guidelines could reduce the annual rate of gonorrhea cases by 200 cases (95% uncertainty interval: 169, 232) per 100,000 MSM population while extending the use of a first-line antibiotic by 0.75 (0.55, 0.95) years. One potential strategy to reduce the incidence of gonorrhea while extending the effective lifespan of antibiotics is to inform treatment guidelines based on local, rather than national, resistance prevalence.

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Section: Discussionmentioning

confidence: 99%

Evaluating spatially adaptive guidelines for the treatment of gonorrhea to reduce the incidence of gonococcal infection and increase the effective lifespan of antibiotics

et al. 2022

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“…Our model assumes complete adherence to the first-line treatment guidelines. While the actual treatment regimens used in the population may differ from the recommended guidelines, recent studies estimate the adherence to the CDC guideline for the treatment of gonorrhea to be around 80% [27]. Relaxing these assumptions could improve the accuracy of projections made by our model, but it is not expected to significantly affect the comparative evaluation of strategies considered here.…”

Section: Plos Medicinementioning

confidence: 99%

Adaptive guidelines for the treatment of gonorrhea to increase the effective life span of antibiotics among men who have sex with men in the United States: A mathematical modeling study

et al. 2020

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Background The rise of gonococcal antimicrobial resistance highlights the need for strategies that extend the clinically useful life span of antibiotics. Because there is limited evidence to support the current practice of switching empiric first-line antibiotic when resistance exceeds 5% in the population, our objective was to compare the impact of alternative strategies on the effective life spans of antibiotics and the overall burden of gonorrhea.

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“…98 In a retrospective review of 542 patients with a mean age of 25 years presenting to a large academic medical center from 2011 to 2013, provider adherence to recommended treatment for gonorrhea was 82%; appropriate follow up occurred in only 31% of cases. 99 Ongoing provider education is key to appropriately diagnosing and treating STIs in AYA.…”

Section: Treatmentmentioning

confidence: 99%

A review of current guidelines and research on the management of sexually transmitted infections in adolescents and young adults

Gannon-Loew

Holland-Hall

2020

Therapeutic Advances in Infection

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Adolescents and young adults are at high risk for sexually transmitted infections (STIs). Providers have the responsibility to accurately manage these infections to prevent medical complications and the spread of STIs. This article will review the epidemiology, screening recommendations, diagnostic tests, and treatment guidelines for STIs most commonly encountered in this population: Chlamydia trachomatis, Neisseria gonorrhoeae, Herpes simplex virus, and Trichomonas vaginalis, as well as the sexually associated infection bacterial vaginosis. This review will discuss ongoing research that explores ways to improve the management of STIs in adolescents and young adults.

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Identifying variations in adherence to the CDC sexually transmitted disease treatment guidelines of Neisseria gonorrhoeae

Cited by 7 publications

References 4 publications

Evaluating spatially adaptive guidelines for the treatment of gonorrhea to reduce the incidence of gonococcal infection and increase the effective lifespan of antibiotics

Evaluating spatially adaptive guidelines for the treatment of gonorrhea to reduce the incidence of gonococcal infection and increase the effective lifespan of antibiotics

Adaptive guidelines for the treatment of gonorrhea to increase the effective life span of antibiotics among men who have sex with men in the United States: A mathematical modeling study

A review of current guidelines and research on the management of sexually transmitted infections in adolescents and young adults

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