Identifying unstable CNG repeat loci in the human genome: a heuristic approach and implications for neurological disorders
Varun Suroliya,
Bharathram Uppili,
Manish Kumar
et al.
Abstract:Tandem nucleotide repeat (TNR) expansions, particularly the CNG nucleotide configuration, are associated with a variety of neurodegenerative disorders. In this study, we aimed to identify novel unstable CNG repeat loci associated with the neurogenetic disorder spinocerebellar ataxia (SCA). Using a computational approach, 15,069 CNG repeat loci in the coding and noncoding regions of the human genome were identified. Based on the feature selection criteria (repeat length >10 and functional location of repeats… Show more
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