Identifying the Zheng in psoriatic patients based on latent class analysis of traditional Chinese medicine symptoms and signs

Abstract

BackgroundThere are approximately five Zhengs reported in psoriatic patients. Systematic data collection and proper analysis for the classification of psoriasis have been lacking. This study aims to cluster the Zhengs in psoriatic patients based on the application of a checklist of traditional Chinese medicine (TCM) symptoms and signs followed by latent class analysis (LCA).MethodsA cross-sectional study of 507 psoriatic patients aged above 10 years was performed in Yunnan Provincial Hospital of TCM and the First Affiliated Hospital of Kunming Medicine University from October 2010 to September 2011 using a TCM symptoms and signs checklist obtained from 16 TCM experts by the Delphi technique. LCA was applied to obtain the best fitted model for clustering of symptoms and signs that can be interpreted as underlying Zhengs of psoriasis.ResultsThe LCA identified three Zhengs: dampness-heat Zheng (35.1%); blood heat Zheng (34.7%); and yin deficiency and blood dryness Zheng (30.2%). The first Zheng was associated with winter, the second with male sex, old age, smoking, and drinking alcohol, and the third with outpatient status, which reflected a mild disease course.ConclusionsIn this study, 507 psoriasis patients were clustered into three Zhengs, which had different associated factors.

The traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology

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A data-driven method for syndrome type identification and classification in traditional Chinese medicine

“…The studies primarily focus on infectious diseases, and also cover mental or behavior problems, diseases of the musculoskeletal system, disease of the digestive system, and neoplasms. Recently, LCA has also been used to identify TCM syndrome types among psoriatic patients [16].…”

Identification and determination of myriocin in Isaria cicadae and its allies by LTQ-Orbitrap-HRMS

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