Identifying the translational complexity of magnetic resonance spectroscopy in neonates and infants

Moss, Hunter G.; Jenkins, Dorothea; Yazdani, Milad; Brown, Truman R.

doi:10.1002/nbm.4089

Cited by 8 publications

(4 citation statements)

References 27 publications

(53 reference statements)

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“…This discrepancy may be due to a more reliable quantification of NAA and Cho at a long TE, in which there are fewer overlapping metabolite peaks, as has previously been reported. 26 As markers of neuronal metabolic health 42 and myelination, NAA and Cho are both complementary and additive in our models. 1,[9][10][11] Lower concentrations of NAA in the deep gray nuclei of the BG reflect metabolic impairment, lower neuronal volume or density, and possibly insufficient dendritic arborization in the thalamus, responsible for sensory-input integration and regulation of voluntary movement.…”

Section: Discussionmentioning

confidence: 98%

“…The LCModel 25 (http://www. lcmodel.com/) quantified metabolite ratios to creatine using a simulated metabolite basis set 26 generated with the VeSPA software package 27 (https://github.com/vespa-mrs/ vespa) with any additional metabolite ratios computed from these (Online Supplemental Data). Processed spectra were visually inspected for quality of fit, and the metabolite ratio inclusion criterion was the Cramer-Rao lower bound of ,20%.…”

Section: Image Acquisition and Processingmentioning

confidence: 99%

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Quantitative Diffusion and Spectroscopic Neuroimaging Combined with a Novel Early-Developmental Assessment Improves Models for 1-Year Developmental Outcomes

Moss

Wolf²,

Coker-Bolt³

et al. 2021

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: Preterm infants are at risk for overt and silent CNS injury, with developmental consequences that are difficult to predict. The novel Specific Test of Early Infant Motor Performance, administered in preterm infants at term age, is indicative of later developmental gross motor and cognitive scores at 12 months. Here, we assessed whether functional performance on this early assessment correlates with CNS integrity via MR spectroscopy or diffusional kurtosis imaging and whether these quantitative neuroimaging methods improve predictions for future 12-month developmental scores.MATERIALS AND METHODS: MR spectroscopy and quantitative diffusion MR imaging data were acquired in preterm infants (n ¼ 16) at term. Testing was performed at term and 3 months using the Specific Test of Early Infant Motor Performance and the Bayley Scales of Infant and Toddler Development, Third Edition, at 12 months. We modeled the relationship of MR spectroscopy and diffusion MR imaging data with both test scores via multiple linear regression.RESULTS: MR spectroscopy NAA ratios at a TE of 270 ms in the frontal WM and basal ganglia and kurtosis metrics in major WM tracts correlated strongly with total Specific Test of Early Infant Motor Performance scores. The addition of MR spectroscopy and diffusion separately improved the functional predictions of 12-month outcomes.CONCLUSIONS: Microstructural integrity of the major WM tracts and metabolism in the basal ganglia and frontal WM strongly correlate with early developmental performance, suggesting that the Specific Test of Early Infant Motor Performance reflects CNS integrity after preterm birth. This study demonstrates that combining quantitative neuroimaging and early functional movement improves the prediction of 12-month outcomes in premature infants.

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Section: Discussionmentioning

confidence: 98%

Section: Image Acquisition and Processingmentioning

confidence: 99%

Quantitative Diffusion and Spectroscopic Neuroimaging Combined with a Novel Early-Developmental Assessment Improves Models for 1-Year Developmental Outcomes

Moss

Wolf²,

Coker-Bolt³

et al. 2021

AJNR Am J Neuroradiol

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“…MRI generates images of the internal organs of the human body using a magnetic field and radio waves. Due to its good efficacy, it has a wide range of clinical applications (31). DWI technology also has a clear positive significance for clinical diagnosis, and can be used to effectively assess clinical symptoms, such as brain edema, and provide a scientific basis for clinical treatment (32).…”

Section: Discussionmentioning

confidence: 99%

The application of magnetic resonance imaging and diffusion-weighted imaging in the diagnosis of hypoxic-ischemic encephalopathy and kernicterus in premature infants

et al. 2021

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Background: To explore the application of magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in the diagnosis of hypoxic-ischemic encephalopathy and kernicterus in premature infants.Methods: Fifty-eight premature infants with hypoxic-ischemic encephalopathy and fifty-eight premature infants with kernicterus who were examined and treated in our hospital between January 2018 and January 2021 were assigned to the observation group or the control group. All patients were examined by MRI imaging and DWI imaging, and the examination results were compared between the two groups.Results: No significant differences were found in sensitivity, specificity, positive predictive value, or negative predictive value between the observation group and the control group (P>0.05). MRI could clearly visualize the signal changes of patients, whereas DWI did not show any signal changes. There was no significant difference between MRI and DWI in the diagnosis of hypoxic-ischemic encephalopathy in premature infants. Further, there was no significant difference in the diagnostic performance of MRI between the observation group and the control group (P>0.05). However, the diagnostic performance of DWI in the control group was better than that in the observation group, and the difference was statistically significant (P<0.05).Conclusions: MRI and DWI imaging have high detection rates for the diagnosis of hypoxic-ischemic encephalopathy and kernicterus in premature infants. These imaging methods can benefit the treatment of premature infants and have important clinical application value.

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“…In brief, MRS sequences STEAM TE 20 ms and PRESS TE 270 ms were performed with voxels placed in the left basal ganglia (BG) and right frontal white matter, including water reference scans for absolute metabolite concentration. Metabolite concentrations were quantified using LCModel (Moss et al, 2018(Moss et al, , 2019, and scans were excluded if they had poor quality, as described previously (Moss et al, 2018). There were inadequate numbers of post-treatment DKI scans available in this cohort to include in this report.…”

Section: Neuroimagingmentioning

confidence: 99%

Transcutaneous auricular vagus nerve stimulation may benefit from the addition of N-acetylcysteine to facilitate motor learning in infants of diabetic mothers failing oral feeds

Jenkins,

Garner,

Brennan

et al. 2024

Front. Hum. Neurosci.

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ObjectiveThis study aims to determine if pretreating with enteral N-acetylcysteine (NAC) improves CNS oxidative stress and facilitates improvement in oromotor skills during transcutaneous auricular nerve stimulation (taVNS) paired with oral feedings in infants of diabetic mothers (IDMs) who are failing oral feeds.MethodsWe treated 10 IDMs who were gastrostomy tube candidates in an open-label trial of NAC and taVNS paired with oral feeding. NAC (75 or 100 mg/kg/dose) was given by nasogastric (NG) administration every 6 h for 4 days, then combined with taVNS paired with 2 daily feeds for another 14 days. NAC pharmacokinetic (PK) parameters were determined from plasma concentrations at baseline and at steady state on day 4 of treatment in conjunction with magnetic resonance spectroscopic (MRS) quantification of CNS glutathione (GSH) as a marker of oxidative stress. We compared increases in oral feeding volumes before and during taVNS treatment and with a prior cohort of 12 IDMs who largely failed to achieve full oral feeds with taVNS alone.ResultsNAC 100 mg/kg/dose every 6 h NG resulted in plasma [NAC] that increased [GSH] in the basal ganglia with a mean of 0.13 ± 0.08 mM (p = 0.01, compared to baseline). Mean daily feeding volumes increased over 14 days of NAC + taVNS compared to the 14 days before treatment and compared to the prior cohort of 12 IDMs treated with taVNS alone. Seven IDMs reached full oral feeds sufficient for discharge, while three continued to have inadequate intake.ConclusionIn IDM failing oral feeds, NAC 100 mg/kg/dose every 6 h NG for 4 days before and during taVNS paired with oral feeding increased CNS GSH, potentially mitigating oxidative stress, and was associated with improving functional feeding outcomes compared to taVNS alone in a prior cohort. This represents a novel approach to neuromodulation and supports the concept that mitigation of ongoing oxidative stress may increase response to taVNS paired with a motor task.

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Identifying the translational complexity of magnetic resonance spectroscopy in neonates and infants

Cited by 8 publications

References 27 publications

Quantitative Diffusion and Spectroscopic Neuroimaging Combined with a Novel Early-Developmental Assessment Improves Models for 1-Year Developmental Outcomes

Quantitative Diffusion and Spectroscopic Neuroimaging Combined with a Novel Early-Developmental Assessment Improves Models for 1-Year Developmental Outcomes

The application of magnetic resonance imaging and diffusion-weighted imaging in the diagnosis of hypoxic-ischemic encephalopathy and kernicterus in premature infants

Transcutaneous auricular vagus nerve stimulation may benefit from the addition of N-acetylcysteine to facilitate motor learning in infants of diabetic mothers failing oral feeds

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