Identifying the neural network for selective attention to visceral sensation using functional magnetic resonance imaging

GREGORY, L; YAGUEZ, L; ALTMANN, C; WILLIAMS, S; THOMPSON, D; AZIZ, Q

doi:10.1016/s0016-5085(01)80112-8

Cited by 1 publication

(1 citation statement)

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“…However, these concepts provide an important direction for understanding the roles of both H pylori infection and other pro-inflammatory factors that may initiate similar dysfunction. For example, evidence for comparable events in patients with the irritable bowel syndrome, a functional gastrointestinal disorder not related to H pylori infection, support the concept of a disturbance of the gut-brain-gut axis in immune function and neuromuscular activity (20,21). These hypotheses, which also incorporate psychogenic stress as a factor in determining symptom expression, provide a physiological basis for identifying potential new targets for medical therapy.…”

Section: Etiology: Current Conceptsmentioning

confidence: 96%

Etiology of Dyspepsia: Implication for Empiric Therapy

Hunt

Fallone²,

Zanten³

et al. 2002

Canadian Journal of Gastroenterology

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Dyspepsia describes a symptom complex thought to arise in the upper gastrointestinal tract and includes, in addition to epigastric pain or discomfort, symptoms such as heartburn, acid regurgitation, excessive burping or belching, a feeling of slow digestion, early satiety, nausea and bloating. Based on the evidence that heartburn cannot be reliably distinguished from other dyspeptic symptoms, the Rome definition appears to be too narrow and restrictive. It is particularly ill suited to the management of uninvestigated dyspepsia at the level of primary care. In patients presenting with uninvestigated dyspepsia, a symptom benefit is associated with a 'test and treat' approach for Helicobacter pylori infection. A substantial proportion of those who do not benefit prove to have esophagitis on endoscopy. In those with functional dyspepsia, the benefits of H pylori eradication, if any, appear to be modest. Hence, a 'symptom and treat' acid-suppression trial with proton pump inhibitors, and a 'test and treat' strategy for H pylori are two acceptable empirical therapies for patients with univestigated dyspepsia.

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Section: Etiology: Current Conceptsmentioning

confidence: 96%