Identifying the Mechanism of Biosensing with Carbon Nanotube Transistors

Heller, Iddo; Janssens, Anne M.; Männik, Jaan; Minot, Ethan D.; Lemay, Serge G.; Dekker, Cees

doi:10.1021/nl072996i

Cited by 456 publications

(576 citation statements)

References 32 publications

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“…They are widely studied as they relate to many diseases such as cancer and Alzheimers disease [4]. Electronic measurements on ssDNA adsorption on graphene were also performed in a biochemical FET setup, where the effect of DNA adsorption and hybridisation on the source-drain current in graphene sheets was measured upon variation of a gate potential [111,112]. Not surprisingly, ssDNA was found to act as a negative gating agent that increased the hole density in graphene [113,114].…”

Section: Detection Methods Based On Dna Adsorptionmentioning

confidence: 99%

Graphene nanodevices for DNA sequencing

2016

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Fast, cheap, and reliable DNA sequencing could be one of the most disruptive innovations of this decade as it will pave the way for personalised medicine. In pursuit of such technology, a variety of nanotechnology-based approaches have been explored and established including sequencing with nanopores. Due to its unique structure and properties, graphene provides interesting opportunities for the development of a new sequencing technology. In recent years, a wide range of creative ideas for graphene sequencers have been theoretically proposed and the first experimental demonstrations have begun to appear. Here, we review the different approaches to using graphene nanodevices for DNA sequencing, which involve DNA passing through graphene nanopores, nanogaps, and nanoribbons, and the physisorption of DNA on graphene nanostructures. We discuss the advantages and problems of each of these key techniques, and provide a perspective on the use of graphene in future DNA sequencing technology.

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Section: Detection Methods Based On Dna Adsorptionmentioning

confidence: 99%

Graphene nanodevices for DNA sequencing

2016

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“…Therefore, we can unambiguously conclude that NH 3 gas induced SB modulation is a dominant mechanism for our CNT gas sensors at room temperature. Actually, PMMA was widely employed as a passivation material to protect the CNT/metal contact regions for gas , Liu, et al, 2005 and protein sensing (Heller, et al, 2008). However, two major problems exist due to the polymer nature of PMMA.…”

Section: Nh 3 Sensing At Room-temperaturementioning

confidence: 99%

Sensing Mechanisms of Carbon Nanotube Based NH3 Gas Detectors

Peng¹,

Zhang²

2010

Carbon Nanotubes

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“…These characteristics have led to CNTs being considered ideal substrates for electronics (4), sensing systems (5,6), electrocatalytic supports (7), and batteries (8). Furthermore, the different configurations in which CNTs can be arranged broaden their versatility and allow custom design of devices for specific applications.…”

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Quantitative nanoscale visualization of heterogeneous electron transfer rates in 2D carbon nanotube networks

Güell¹,

Ebejer²,

Snowden³

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

113

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Carbon nanotubes have attracted considerable interest for electrochemical, electrocatalytic, and sensing applications, yet there remains uncertainty concerning the intrinsic electrochemical (EC) activity. In this study, we use scanning electrochemical cell microscopy (SECCM) to determine local heterogeneous electron transfer (HET) kinetics in a random 2D network of single-walled carbon nanotubes (SWNTs) on an Si∕SiO 2 substrate. The high spatial resolution of SECCM, which employs a mobile nanoscale EC cell as a probe for imaging, enables us to sample the responses of individual portions of a wide range of SWNTs within this complex arrangement. Using two redox processes, the oxidation of ferrocenylmethyl trimethylammonium and the reduction of ruthenium (III) hexaamine, we have obtained conclusive evidence for the high intrinsic EC activity of the sidewalls of the large majority of SWNTs in networks. Moreover, we show that the ends of SWNTs and the points where two SWNTs cross do not show appreciably different HET kinetics relative to the sidewall. Using finite element method modeling, we deduce standard rate constants for the two redox couples and demonstrate that HET based solely on characteristic defects in the SWNT side wall is highly unlikely. This is further confirmed by the analysis of individual line profiles taken as the SECCM probe scans over an SWNT. More generally, the studies herein demonstrate SECCM to be a powerful and versatile method for activity mapping of complex electrode materials under conditions of high mass transport, where kinetic assignments can be made with confidence.W ithin the family of nanostructured materials, carbon nanotubes (CNTs) have attracted particular attention because they are readily synthesised at low cost, have exceptional electronic properties, exhibit chemical and mechanical stability, and are amenable to a wide range of simple chemical functionalization routes (1-3). These characteristics have led to CNTs being considered ideal substrates for electronics (4), sensing systems (5, 6), electrocatalytic supports (7), and batteries (8). Furthermore, the different configurations in which CNTs can be arranged broaden their versatility and allow custom design of devices for specific applications. Individual single-walled carbon nanotubes (SWNTs) (9), 2D networks (10-12), and 3D nanostructures (13) have all been employed successfully.Understanding heterogeneous electron transfer (HET) at CNTs is of considerable importance, due to the wide range of electroanalytical and electrocatalytic systems based on CNTs (14-17), and also because electrochemistry provides an attractive route to functionalize and tailor the properties of . Probing HET in 1D electrode materials is interesting fundamentally, given their inherent electronic structure and properties (21,22). However, as we highlight herein, despite many studies aimed at characterizing HET at CNTs, substantial questions remain unanswered, such as the location and rate of HET.A popular approach for studying electrochemistry at CNT...

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Identifying the Mechanism of Biosensing with Carbon Nanotube Transistors

Cited by 456 publications

References 32 publications

Graphene nanodevices for DNA sequencing

Graphene nanodevices for DNA sequencing

Sensing Mechanisms of Carbon Nanotube Based NH3 Gas Detectors

Quantitative nanoscale visualization of heterogeneous electron transfer rates in 2D carbon nanotube networks

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