Identifying the asthma research priorities of people with asthma, their carers and other stakeholders

Majellano, Eleanor C; Bell, Rose; Flynn, Anthony; Sivamalai, Sundram; Goldman, Michele; Vaughan, Lauren; Gibson, Peter G.

doi:10.1111/resp.14492

Cited by 11 publications

(13 citation statements)

References 28 publications

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“…The WA Health Child and Adolescent Health Service Ethics Committee approved the project (RGS0000003842), and all participants provided informed consent to participate. Guided by an abridged version of the JLA methodology, 28,29 the project involved…”

Section: Methodsmentioning

confidence: 99%

Priority setting for children and young people with chronic conditions and disabilities

Finlay‐Jones

Sampson

Parkinson

et al. 2023

Health Expectations

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Background: The aim of this project was to identify the top 10 priorities for childhood chronic conditions and disability (CCD) research from the perspectives of children and young people with lived experience, their parents and caregivers and the professionals who work with them. Methods: We conducted a three-stage study based on the James Lind Alliance priority-setting partnership methods. It comprised two online surveys (n = 200; n = 201) and a consensus workshop (n = 21) with these three stakeholder groups in Australia.Results: In the first stage, 456 responses were submitted, which were coded and collapsed into 40 overarching themes. In the second stage, 20 themes were shortlisted, which were further refined in stage 3, before the top 10 priorities being selected. Of these, the top three priorities were improving awareness and inclusion in all aspects of their life (school, work and social relationships), improving access to treatments and support and improving the process of diagnosis.

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Section: Methodsmentioning

confidence: 99%

Priority setting for children and young people with chronic conditions and disabilities

Finlay‐Jones

Sampson

Parkinson

et al. 2023

Health Expectations

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“…12 The treatable traits approach is a model of care that has been designed to address the limitations of the step-care approach to the management of obstructive airway diseases. [13][14][15] The key elements of a treatable traits strategy include the identification of traits that are clinically important, identifiable and treatable. Inherent to the approach is a multidimensional assessment to identify traits followed by individualized treatments implemented to target each trait.…”

Section: Treatable Traitsmentioning

confidence: 99%

Treatable traits, combination inhaler therapy and the future of asthma management

2023

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The landscape of asthma has considerably changed in the last decade. Effective medications and inhaler devices have been developed and integrated into the asthma pharmacopoeia, but unfortunately, the proportion of uncontrolled patients remains unacceptably high. This is now recognized to be mainly due to the inappropriate use of medications or inhaler devices, heterogeneity of the disease or other factors contributing to the disease. Currently, inhaled corticosteroids (ICS), with or without long‐acting beta agonists (LABA), are the cornerstone of asthma management, and recently international guidelines recognized the importance of combination inhaler therapy (ICS/LABA) even in mild asthma. In future, ultra‐long‐acting personalized medications and smart inhalers will complement combination inhaler therapy in order to effectively addresses issues such as adherence, inhaler technique and polypharmacy (both of drugs and devices). Asthma is now acknowledged as a multifaceted cluster of disorders and the treatment model has evolved from one‐size‐fits‐all to precision medicine approaches such as treatable traits (TTs, defined as measurable and treatable clinically important factors) which encourages the quality use of medications and identification and management of all underlying behavioural and biological treatable risk factors. TT requires research and validation in a clinical context and the implementation strategies and efficacy in various settings (primary/secondary/tertiary care, low‐middle income countries) and populations (mild/moderate/severe asthma) are currently evolving. Combination inhaler therapy and the TTs approach are complementary treatment approaches. This review examines the current status of personalized medicine and combination inhaler therapy, and describes futuristic views for these two strategies.

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“…These early-life disorders also have a significant impact on healthcare systems worldwide, representing one of the most common reasons for hospital presentation and contributing billions of dollars to direct and indirect economic and healthcare costs [2,3]. While significant advances have been made in our understanding of disease pathophysiology, endotypes, and triggers, there are still major knowledge gaps leading to an ongoing lack of optimal diagnostic, disease prevention, and treatment options [4,5].…”

Section: Introductionmentioning

confidence: 99%

Airway Epithelium Respiratory Illnesses and Allergy (AERIAL) birth cohort: study protocol

Kicic-Starcevich

Hancock

Iosifidis

et al. 2023

Preprint

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Introduction: Recurrent wheezing disorders including asthma are complex and heterogeneous diseases that affect up to 30% of all children, contributing to a major burden on children, their families, and global healthcare systems. It is now recognized that a dysfunctional airway epithelium plays a central role in the pathogenesis of recurrent wheeze, although the underlying mechanisms are still not fully understood. This prospective birth cohort aims to bridge this knowledge gap by investigating the influence of intrinsic epithelial dysfunction on the risk for developing respiratory disorders and the modulation of this risk by maternal morbidities, in utero exposures, and respiratory exposures in the first year of life. Methods and Analysis: The Airway Epithelium Respiratory Illnesses and Allergy (AERIAL) study is nested within the ORIGINS Project and will monitor 400 infants from birth to five years. The primary outcome of the AERIAL study will be the identification of epithelial endotypes and exposure variables that influence the development of recurrent wheezing, asthma, and allergic sensitisation. Nasal respiratory epithelium at birth to six weeks, one, three, and five years will be analysed by bulk RNA-seq and DNA methylation sequencing. Maternal morbidities and in utero exposures will be identified on maternal history and their effects measured through transcriptomic and epigenetic analyses of the amnion and newborn epithelium. Exposures within the first year of life will be identified based on infant medical history as well as on background and symptomatic nasal sampling for viral PCR and microbiome analysis. Daily temperatures and symptoms recorded in a study-specific Smartphone App will be used to identify symptomatic respiratory illnesses. Ethics and Dissemination: Ethical approval has been obtained from Ramsey Health Care HREC WA-SA (#1908). Results will be disseminated through open-access peer-reviewed manuscripts, conference presentations, and through different media channels to consumers, ORIGINS families, and the wider community.

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Identifying the asthma research priorities of people with asthma, their carers and other stakeholders

Cited by 11 publications

References 28 publications

Priority setting for children and young people with chronic conditions and disabilities

Priority setting for children and young people with chronic conditions and disabilities

Treatable traits, combination inhaler therapy and the future of asthma management

Airway Epithelium Respiratory Illnesses and Allergy (AERIAL) birth cohort: study protocol

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