Identifying target regions for vigilance improvement under hormone replacement therapy in postmenopausal syndrome patients by means of electroencephalographic tomography (LORETA)

Saletu, B.; Anderer, P.; Saletu-Zyhlarz, Gerda; Gruber, Doris; Metka, M.; Huber, Johannes

doi:10.1007/s00213-004-2029-x

Cited by 15 publications

(11 citation statements)

References 52 publications

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“…Consistent with findings from functional neuroimaging (Buchsbaum et al, 1990;Lewin et al, 1996;Paus et al, 1997;Sturm et al, 2004) and neurophysiological studies (Bearden, Cassisi, & White, 2004;Saletu et al, 2005), the findings from the present investigation further implicate the right cerebral hemisphere in the sustained attention processes. The results of this study also extend the findings of previous research by providing researchers with a non-invasive methodology by which an individual's level of cortical arousal could be used to reliably predict his or her behavioral performance.…”

Section: Discussionsupporting

confidence: 91%

A Quantitative Electroencephalographic Correlate of Sustained Attention Processing

Arruda

Amoss

Coburn

et al. 2007

Appl Psychophysiol Biofeedback

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The objective of the present investigation was to develop a quantitative electroencephalographic measure (qEEG) that is sensitive and specific to changes in sustained human performance. A principal components analysis (PCA) was performed on the qEEG obtained from participants during a continuous performance test. Measures of sensitivity (proportion of correctly identified correct responses, or hits) and specificity (proportion of correctly identified incorrect responses, or misses) were calculated to assess the classification accuracy of each newly derived component. PCA solutions produced a right hemisphere component comprised of beta-wave activity measured from four unipolar sites (F8, C6a, C6, and T4) that appeared to be sensitive and specific to changes in human performance. Results provide evidence for the validity of a right hemisphere qEEG measure that is sensitive and specific to changes in sustained human performance. Consistent with the findings of previous research, the present findings implicate the right cerebral hemisphere in the sustained attention process.Despite recent advances in functional neuroimaging and other neurophysiological techniques very little research has been dedicated to the identification and the development

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Section: Discussionsupporting

confidence: 91%

A Quantitative Electroencephalographic Correlate of Sustained Attention Processing

Arruda

Amoss

Coburn

et al. 2007

Appl Psychophysiol Biofeedback

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“…It has been shown that young women express relatively greater resting right frontal activity during the periovulatory phase compared to the menstrual phase 26 . An electroencephalographic study has also shown that the right hemisphere vigilance system can be enhanced by hormonal therapy in women with postmenopausal syndrome 27 . Estrogenic effects were reported to occur in the limbic-amygdala-hippocampal structures 5 , which can modulate higher perseverance for positive reward during the periovulatory phase 28 .…”

Section: Discussionmentioning

confidence: 99%

Cerebrovascular Reactivity across the Menstrual Cycle in Young Healthy Women

et al. 2013

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“…Considering that MtFs identify with women, this is in line with evidence for estradiol enhancing right hemispheric functioning in women (Bayer & Hausmann, 2009; Hausmann, Becker, Gather, & Gunturkun, 2002; Weis et al., 2008) in regions involved in the fronto‐parietal network (Saletu et al., 2005). Even low doses of estradiol facilitate the functioning of brain regions involved in visual perception and attentional processes (Stevens, Clark, & Prestwood, 2005).…”

Section: Discussionmentioning

confidence: 99%

Male‐to‐female gender dysphoria: Gender‐specific differences in resting‐state networks

et al. 2017

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IntroductionRecent research found gender‐related differences in resting‐state functional connectivity (rs‐FC) measured by functional magnetic resonance imaging (fMRI). To the best of our knowledge, there are no studies examining the differences in rs‐FC between men, women, and individuals who report a discrepancy between their anatomical sex and their gender identity, i.e. gender dysphoria (GD).MethodsTo address this important issue, we present the first fMRI study systematically investigating the differences in typical resting‐state networks (RSNs) and hormonal treatment effects in 26 male‐to‐female GD individuals (MtFs) compared with 19 men and 20 women.ResultsDifferences between male and female control groups were found only in the auditory RSN, whereas differences between both control groups and MtFs were found in the auditory and fronto‐parietal RSNs, including both primary sensory areas (e.g. calcarine gyrus) and higher order cognitive areas such as the middle and posterior cingulate and dorsomedial prefrontal cortex. Overall, differences in MtFs compared with men and women were more pronounced before cross‐sex hormonal treatment. Interestingly, rs‐FC between MtFs and women did not differ significantly after treatment. When comparing hormonally untreated and treated MtFs, we found differences in connectivity of the calcarine gyrus and thalamus in the context of the auditory network, as well as the inferior frontal gyrus in context of the fronto‐parietal network.ConclusionOur results provide first evidence that MtFs exhibit patterns of rs‐FC which are different from both their assigned and their aspired gender, indicating an intermediate position between the two sexes. We suggest that the present study constitutes a starting point for future research designed to clarify whether the brains of individuals with GD are more similar to their assigned or their aspired gender.

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Identifying target regions for vigilance improvement under hormone replacement therapy in postmenopausal syndrome patients by means of electroencephalographic tomography (LORETA)

Abstract: Electroencephalographic tomography (LORETA) identified the right-hemispheric vigilance system as the target region of Climodien.

Cited by 15 publications

References 52 publications

A Quantitative Electroencephalographic Correlate of Sustained Attention Processing

A Quantitative Electroencephalographic Correlate of Sustained Attention Processing

Cerebrovascular Reactivity across the Menstrual Cycle in Young Healthy Women

Male‐to‐female gender dysphoria: Gender‐specific differences in resting‐state networks

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