Identifying subgroups of obesity using the product of triglycerides and glucose: the Korea National Health and Nutrition Examination Survey, 2008–2010

Lee, Seung‐Hwan; Han, Kyungdo; Yang, Hae Kyung; Kim, Mee Kyoung; Yoon, Kun‐Ho; Kwon, Hyuk‐Sang; Park, Young Jun

doi:10.1111/cen.12502

Cited by 72 publications

(51 citation statements)

References 35 publications

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“…The TyG index value in the present investigation is in agreement with the majority of the reported adult literature , but higher than some others . Some investigators calculated the TyG index as a function of the log rather than the Ln (natural log) , which would explain the different numerical value for the index.…”

Section: Discussionsupporting

confidence: 90%

“…The baseline TyG index was significantly higher in those who developed diabetes vs. those who did not. Moreover, the incidence of diabetes increased in proportion to the TyG index quartiles, with a fourfold higher risk of diabetes in the highest vs. the lowest quartile . Lastly, the predictive power of TyG index was better than the TG/HDL ratio or the HOMA‐IR .…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Triglyceride glucose index as a surrogate measure of insulin sensitivity in obese adolescents with normoglycemia, prediabetes, and type 2 diabetes mellitus: comparison with the hyperinsulinemic-euglycemic clamp

et al. 2015

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 95%

Triglyceride glucose index as a surrogate measure of insulin sensitivity in obese adolescents with normoglycemia, prediabetes, and type 2 diabetes mellitus: comparison with the hyperinsulinemic-euglycemic clamp

et al. 2015

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“…Notably, the cut-off point of 8.5 was quite different from the finding of 4.58 by Simental-Mendia [7], the reason for this may be explained by the different metabolic status among subjects from the two studies or the different ethnicities. The TyG level in our study was similar to that of other population from Korea [27, 32], America [33], France [30], and Spain [26], whereas the level of TyG in studies from Mexico was close to that of participants from Italy [31]. We also found that the diagnostic accuracy of TyG was superior to ALT, even if the optimal cut-off point of ALT was 20.5 U/L with a sensitivity of 66.1% and specificity of 65.9%.…”

Section: Discussionsupporting

confidence: 89%

The triglyceride and glucose index (TyG) is an effective biomarker to identify nonalcoholic fatty liver disease

et al. 2017

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BackgroundThe triglyceride and glucose index (TyG) has been proposed as a marker of insulin resistance. We aimed to investigate the ability of TyG, through comparing with the predictive value of alanine aminotransferase (ALT), to identify individuals at risk for nonalcoholic fatty liver disease (NAFLD).MethodsA cross-sectional study was conducted in a Chinese health examination cohort of 10 761 people aged above 20 years. NAFLD was diagnosed by ultrasonography.ResultsCompared with the participants in the lowest quartile of TyG, the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD were 1.8 (1.5–2.1), 3.0 (2.5–3.5), and 6.3 (5.3–7.5) for those in the second, the third, and the fourth quartile of TyG, whereas the corresponding ORs (95% CI) for NAFLD were 1.5 (1.3–1.7), 1.9 (1.6–2.2), and 3.1 (2.6–3.7) for the upper three quartiles of ALT. These results suggested that TyG was superior to ALT in association with NAFLD risk. According to the ROC analysis, the optimal cut-off point of TyG for NAFLD was 8.5 and the area under the ROC curve (AUC) was 0.782 (95% CI 0.773–0.790), with 72.2 and 70.5% sensitivity and specificity, respectively. The AUC of TyG was larger than that of ALT (0.715 (95% CI 0.705–0.725), P for difference <0.0001), whereas the largest AUC was obtained when adding TyG to ALT (0.804 (95% CI 0.795–0.812), P for difference <0.0001).ConclusionsTyG is effective to identify individuals at risk for NAFLD. A TyG threshold of 8.5 was highly sensitive for detecting NAFLD subjects and may be suitable as a diagnostic criterion for NAFLD in Chinese adults.Electronic supplementary materialThe online version of this article (doi:10.1186/s12944-017-0409-6) contains supplementary material, which is available to authorized users.

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“…The findings of some studies revealed that there is a strong relationship between hypertriglyceridemia and the risk of Type 2 diabetes (16)(17)(18), however, the studies on its relationship with GDM is so restricted, especially in Middle Eastern mothers. This study aimed to clarify the association of serum levels of triglycerides during the 1st trimester with the risk of developing GDM.…”

Section: Introductionmentioning

confidence: 99%

Indicators of Obesity and Serum Levels of Triglycerides in the First Trimester of Pregnancy as the Predictors of Gestational Diabetes Mellitus among Urmia Women

et al. 2018

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Background: Obesity is a major risk factor of gestational diabetes mellitus (GDM), therefore, we aimed to determine which indicators of obesity can be used as predictors of GDM and also to study the association of maternal serum levels of triglycerides (TG) in early pregnancy to expression of GDM. Methods: A total of 436 primigravida women, who attended public health centers in 6 -10 weeks of gestation, were prospectively followed until 24 -28 weeks of gestation to control the expression of GDM. The indicators of abdominal obesity and the serum concentration of TG were measured at 6-10 weeks of gestation. All participants underwent a 75 g oral glucose tolerance test (OGTT) as a routine test at 24 -28 weeks. Results: The incidence of GDM among our participants was 9.6%. The serum concentration of TG in 16.5% of them was more than 199 mg\dL. The majority of participants (62.8%) had a body mass index (BMI) more than its normal range. Waist circumference (WC) in the majority (84.4%) was 80 -95.9 cm. The mean (SD) waist to height ratio (WHtR) and waist to hip ratio (WHR) were 0.58 (0.05) and 0.84 (0.06), respectively. WC, WHtR, WHR, BMI, and the serum levels of TG in early pregnancy are associated with the expression of GDM. Conclusions: Abdominal obesity and serum levels of TG can be used as early predictors of GDM. Strategies consisted of monitoring of TG levels in women planning for pregnancy as well as training obese and overweight women to modify their lifestyle in the means of decreasing the body fat mass can help to partially prevent GDM.

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Identifying subgroups of obesity using the product of triglycerides and glucose: the Korea National Health and Nutrition Examination Survey, 2008–2010

Abstract: These data highlight the value of the TyG index in discriminating those subjects with higher risks of metabolic diseases.

Cited by 72 publications

References 35 publications

Triglyceride glucose index as a surrogate measure of insulin sensitivity in obese adolescents with normoglycemia, prediabetes, and type 2 diabetes mellitus: comparison with the hyperinsulinemic-euglycemic clamp

Triglyceride glucose index as a surrogate measure of insulin sensitivity in obese adolescents with normoglycemia, prediabetes, and type 2 diabetes mellitus: comparison with the hyperinsulinemic-euglycemic clamp

The triglyceride and glucose index (TyG) is an effective biomarker to identify nonalcoholic fatty liver disease

Indicators of Obesity and Serum Levels of Triglycerides in the First Trimester of Pregnancy as the Predictors of Gestational Diabetes Mellitus among Urmia Women

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