Identifying Risk Factors for Renal Failure and Myocardial Infarction Following Colorectal Surgery

Causey, Marlin Wayne; Maykel, Justin A.; Hatch, Quinton; Miller, Seth; Steele, Scott R.

doi:10.1016/j.jss.2011.03.027

Cited by 43 publications

(43 citation statements)

References 11 publications

(13 reference statements)

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“…For instance, from the patients who underwent laparoscopic sigmoid resection for diverticular disease, 1.14% had cardiac complications [16], while 11.2% patients suffered an AMI after colorectal surgery [17]. Patients undergoing head and neck surgery had an AMI rate of 0.3% [18].…”

Section: Discussionmentioning

confidence: 99%

Inpatient versus outpatient onsets of acute myocardial infarction

Erné

Bertel

Urban

et al. 2015

European Journal of Internal Medicine

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Section: Discussionmentioning

confidence: 99%

Inpatient versus outpatient onsets of acute myocardial infarction

Erné

Bertel

Urban

et al. 2015

European Journal of Internal Medicine

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“…Causey and colleagues reported an incidence of postoperative AKI of 11.8% in patients submitted to colorectal surgery. In this study, AKI was defined as an increase in SCr ≥ 50% and not considered an increase in SCr ≥ 0.3 mg/dL within a 48-hour timeframe and UO variations [18]. A large multicentric study performed in mixed cardiac and noncardiac surgery population described a lower incidence of postoperative AKI (1.1%).…”

Section: Discussionmentioning

confidence: 99%

Acute Kidney Injury after Major Abdominal Surgery: A Retrospective Cohort Analysis

Teixeira

Rosario

Rodrigues

et al. 2014

Critical Care Research and Practice

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Background. We analyzed the incidence, risk factors, and prognosis of acute kidney injury (AKI) in a cohort of patients undergoing major abdominal surgery. Methods. A total of 450 patients were retrospectively studied. AKI was defined by an increase in serum creatinine (SCr) ≥ 0.3 mg/dl or by an increase in SCr ≥ 50% and/or by a decrease in urine output to 0.5 ml/kg/hour for 6 hours, in the first 48 hours after surgery. Logistic regression method was used to determine predictors of AKI and in-hospital mortality. A two-tailed P value <0.05 was considered significant. Results. One hundred one patients (22.4%) had postoperative AKI. Age (adjusted odds ratio (OR) 1.02, 95% confidence interval (CI) 1.01–1.05), nonrenal Revised Cardiac Risk Index score (adjusted OR 1.9, 95% CI 1.3–3.1, P = 0.003), intraoperative erythrocytes transfusions (adjusted OR 2.2, 95% CI 1.4–3.5, P <.0001), and nonrenal Simplified Acute Physiology Score II (adjusted OR 1.03, 95% CI 1.01–1.06, P = 0.0191) were associated with postoperative AKI. AKI was associated with increased in-hospital mortality (20.8% versus 2.3%, P <.0001; unadjusted OR 11.2, 95% CI 4.8–26.2, P <.0001; adjusted OR 3.7, 95% CI 1.2–11.7, P = 0.024). Conclusion. AKI was common in patients undergoing major abdominal surgery and was associated with in-hospital mortality.

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“…anesthetized anemic sheep where transfusion of renitrosylated RBCs, but not untreated blood, increased kidney blood flow and maintained GFR. Intraoperative blood transfusion is a well-recognized risk factor for acute kidney injury (AKI) (43)(44)(45), and the incidence of transfusion-associated AKI is amplified by preoperative anemia (44). Thus, occurrence rates of AKI may be a useful measure of the O 2 delivery capability of banked blood.…”

Section: Discussionmentioning

confidence: 99%

S-nitrosylation therapy to improve oxygen delivery of banked blood

Reynolds¹,

Bennett²,

Cina

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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From the perspectives of disease transmission and sterility maintenance, the world's blood supplies are generally safe. However, in multiple clinical settings, red blood cell (RBC) transfusions are associated with adverse cardiovascular events and multiorgan injury. Because ∼85 million units of blood are administered worldwide each year, transfusion-related morbidity and mortality is a major public health concern. Blood undergoes multiple biochemical changes during storage, but the relevance of these changes to unfavorable outcomes is unclear. Banked blood shows reduced levels of S-nitrosohemoglobin (SNO-Hb), which in turn impairs the ability of stored RBCs to effect hypoxic vasodilation. We therefore reasoned that transfusion of SNO-Hb-deficient blood may exacerbate, rather than correct, impairments in tissue oxygenation, and that restoration of SNO-Hb levels would improve transfusion efficacy. Notably in mice, administration of banked RBCs decreased skeletal muscle pO 2 , but infusion of renitrosylated cells maintained tissue oxygenation. In rats, hemorrhage-induced reductions in muscle pO 2 were corrected by SNO-Hb-repleted RBCs, but not by control, stored RBCs. In anemic awake sheep, stored renitrosylated, but not control RBCs, produced sustained improvements in O 2 delivery; in anesthetized sheep, decrements in hemodynamic status, renal blood flow, and kidney function incurred following transfusion of banked blood were also prevented by renitrosylation. Collectively, our findings lend support to the idea that transfusions may be causally linked to ischemic events and suggest a simple approach to prevention (i.e., SNO-Hb repletion). If these data are replicated in clinical trials, renitrosylation therapy could have significant therapeutic impact on the care of millions of patients.ethyl nitrite | hemoglobin cysbeta93 | nitric oxide | storage lesion

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Identifying Risk Factors for Renal Failure and Myocardial Infarction Following Colorectal Surgery

Cited by 43 publications

References 11 publications

Inpatient versus outpatient onsets of acute myocardial infarction

Inpatient versus outpatient onsets of acute myocardial infarction

Acute Kidney Injury after Major Abdominal Surgery: A Retrospective Cohort Analysis

S-nitrosylation therapy to improve oxygen delivery of banked blood

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