Identifying risk factors for cutaneous disease among solid organ transplant recipients: A retrospective review

Shope, Chelsea; Andrews, Laura; Leath, Mary Nan; Linkous, Courtney; Lee, Lara Wine

doi:10.1016/j.jdin.2023.02.003

Cited by 1 publication

(4 citation statements)

References 34 publications

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“…25 In a separate study by Shope et al, of a total of 163 darker-skinned RTRs, 7 patients (4.3%) developed skin cancer and one-third of these occurred in the groin or buttock regions. 26 In the present study, only one skin cancer occurred on a non-sun-exposed site in an RTR with FPIII-VI. The patient was Brazilian and developed an anal squamous cell carcinoma on a background of condyloma acuminata, which is in keeping with the proposed higher risk of anogenital cancers in the presence of transforming HPV.…”

Section: Discussioncontrasting

confidence: 40%

“…NMSC was less common in NHBs (2.24%) occurring exclusively on non‐sun‐exposed skin in the anogenital region and were cSCC, with 83% demonstrating p16 positivity, a biomarker for transforming HPV infection 25 . In a separate study by Shope et al., of a total of 163 darker‐skinned RTRs, 7 patients (4.3%) developed skin cancer and one‐third of these occurred in the groin or buttock regions 26 …”

Section: Discussionmentioning

confidence: 97%

“…One important difference in this study compared to the prior studies, is the even distribution of ethnicities between FP skin types III, IV, V, and VI. In comparison, the prior studies included patients in the PwSOC cohort who primarily identified as Black, comprising 91.7% of the patients in the study by Shope et al and 100% of the patients in the study by Takeda et al 25,26 The authors in these studies alluded to the possibility of racial variation in HPV types with oncogenic variants being more prevalent in Black individuals. 27 This may partly explain the disparity in incidence rates of anogenital skin cancer between the prior studies in comparison to the present study.…”

Section: Discussionmentioning

confidence: 99%

“…In comparison, the prior studies included patients in the PwSOC cohort who primarily identified as Black, comprising 91.7% of the patients in the study by Shope et al. and 100% of the patients in the study by Takeda et al 25,26 . The authors in these studies alluded to the possibility of racial variation in HPV types with oncogenic variants being more prevalent in Black individuals 27 .…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Skin cancer in renal transplant recipients: outcomes from a safety net hospital in Boston

Sachedina,

Gibson,

Xia

et al. 2024

Int J Dermatology

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BackgroundRenal transplant recipients (RTRs) are prone to skin cancer due to the immunosuppression required to maintain graft function. Existing studies of skin cancer in RTRs focus on patients with Fitzpatrick skin types I‐II, with limited documentation of incidence in skin types III‐VI. This study seeks to better characterize skin cancers in RTRs with skin types III‐VI.Primary aimsCompare the incidence of skin cancer in RTRs of skin types I‐II with skin types III‐VI.Secondary aimsExplore the association between the development of skin cancer and other contributing factors in RTRs of skin types I‐VI.MethodsRetrospective chart review of RTRs at a single institution between January 1, 2000 and December 31, 2022. Patients were followed from the date of transplant to the last clinical follow‐up or death. 777 RTRs were included in the study, including 245 patients with Fitzpatrick skin types I‐II and 532 with skin types III‐VI. A total of 48 patients developed NMSCs, 2 patients developed melanoma, and 3 patients developed Kaposi sarcoma.Results and conclusionsThere is a higher incidence of skin cancer in RTRs with Fitzpatrick skin types III‐VI compared to the reported incidence among non‐transplant recipients of the same skin types, but the incidence remains considerably lower compared to RTR of skin types I‐II.

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Section: Discussioncontrasting

confidence: 40%

Section: Discussionmentioning

confidence: 97%