Identifying putative cerebrospinal fluid biomarkers of <scp>amyotrophic lateral sclerosis</scp> in a north Indian population

Khosla, Radhika; Rain, Manjari; Chawathey, Shreyas; Modgil, Shweta; Tyagi, Rahul; Thakur, Keshav; Pannu, Viraaj; Sharma, Suresh; Anand, Akshay

doi:10.1002/mus.27026

Cited by 10 publications

(8 citation statements)

References 44 publications

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“…Subsequent studies have further confirmed the downregulation of VEGF in the spinal cord of SOD mice [ 16 , 19 ]. Consistent with this observation, reports indicate a reduction in VEGF levels in both the spinal cord and cerebrospinal fluid (CSF) of ALS patients [ [20] , [21] , [22] ].…”

Section: Introductionsupporting

confidence: 61%

VEGF expression disparities in brainstem motor neurons of the SOD1G93A ALS model: Correlations with neuronal vulnerability

Silva-Hucha,

Fernández de Sevilla,

Humphreys

et al. 2024

Neurotherapeutics

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Section: Introductionsupporting

confidence: 61%

VEGF expression disparities in brainstem motor neurons of the SOD1G93A ALS model: Correlations with neuronal vulnerability

Silva-Hucha,

Fernández de Sevilla,

Humphreys

et al. 2024

Neurotherapeutics

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“…The full text of 10 studies was further evaluated. Finally, a total of seven studies were included in the meta-analysis [25][26][27][28][29][30][31].…”

Section: Study Selectionmentioning

confidence: 99%

The Role of TAR DNA Binding Protein 43 (TDP-43) as a CandiDate Biomarker of Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis

et al. 2023

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Background: TAR DNA-binding protein 43 (TDP-43) aggregation in neuronal cells is recognized as a hallmark of amyotrophic lateral sclerosis (ALS). Although the literature strongly supports the pathogenetic role of TDP-43 in ALS pathogenesis, the role of TDP-43 as a biomarker of ALS is controversial. We performed a systematic review and meta-analysis to assess the diagnostic performance of TDP-43 for ALS. Methods: Relevant publications were identified by a systematic literature search on PubMed and Web of Science from their inception to April 8, 2022. Results: Seven studies, including 472 individuals, of whom 254 had ALS according to the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale, met the inclusion criteria for our meta-analysis. According to the random-effects model, CSF TDP-43 levels are higher in ALS patients compared with control groups. Conclusions: CSF TDP-43 could represent a biomarker of ALS, but further studies are mandatory before drawing conclusions.

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“…However, increased VEGF-A expression exhibits a neuroprotective effect on hypoxic motor neurons, hampering ALS-like motor neuron degeneration, and vice versa. 34 Additionally, VEGF-A promotes vascular smooth muscle cell proliferation and migration. 35 VEGF-A is also implicated in hematopoiesis, such as blood vessel formation and survival of hematopoietic stem cells (HSCs).…”

Section: Molecular and Functional Characterization Of Vegfmentioning

confidence: 99%

“…The pathogenesis of amyotrophic lateral sclerosis (ALS) is associated with VEGF‐A expression. However, increased VEGF‐A expression exhibits a neuroprotective effect on hypoxic motor neurons, hampering ALS‐like motor neuron degeneration, and vice versa 34 . Additionally, VEGF‐A promotes vascular smooth muscle cell proliferation and migration 35 .…”

Section: Molecular and Functional Characterization Of Vegfmentioning

confidence: 99%

Molecular mechanism of VEGF and its role in pathological angiogenesis

Ahmad

Nawaz

2022

J of Cellular Biochemistry

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Over the last seven decades, a significant scientific contribution took place in the delineation of the implications of vascular endothelial-derived growth factor (VEGF) in the processes of angiogenesis. Under pathological conditions, mainly in response to hypoxia or ischemia, elevated VEGF levels promote vascular damage and the growth of abnormal blood vessels. Indeed, the development of VEGF biology has revolutionized our understanding of its role in pathological conditions. Hence, targeting VEGF or VEGFmediated molecular pathways could be an excellent therapeutic strategy for managing cancers and intraocular neovascular disorders. Although anti-VEGF therapies, such as monoclonal antibodies and small-molecule tyrosine kinase inhibitors, have limited clinical efficacy, they can still significantly improve the overall survival rate. This thus demands further investigation through the development of alternative strategies in the management of VEGF-mediated pathological angiogenesis. This review article focuses on the recent developments toward the delineation of the functional biology of VEGF and the role of anti-VEGF strategies in the management of tumor and eye pathologies. Moreover, therapeutic angiogenesis, an exciting frontier for the treatment of ischemic disorders, is highlighted in this review, including wound healing.

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Identifying putative cerebrospinal fluid biomarkers of amyotrophic lateral sclerosis in a north Indian population

Cited by 10 publications

References 44 publications

VEGF expression disparities in brainstem motor neurons of the SOD1G93A ALS model: Correlations with neuronal vulnerability

VEGF expression disparities in brainstem motor neurons of the SOD1G93A ALS model: Correlations with neuronal vulnerability

The Role of TAR DNA Binding Protein 43 (TDP-43) as a CandiDate Biomarker of Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis

Molecular mechanism of VEGF and its role in pathological angiogenesis

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