Identifying prothrombin and bone sialoprotein as potential drug targets for idiopathic pulmonary fibrosis
Yusha Chen,
Siyu Cao,
Shuai Shao
et al.
Abstract:Background
Idiopathic Pulmonary Fibrosis (IPF) is a fatal disease with scarce therapeutic alternatives, which imposes a significant economic burden on society. The identification of novel drug targets is thus critically essential. Plasma proteins with discernible causal evidence hold promise as viable drug targets for this condition.
Methods
We performed a proteome-wide Mendelian randomization (MR) analysis to assess the causal effects of 4,907 circulating proteins from… Show more
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