Identifying potential microRNA biomarkers for colon cancer and colorectal cancer through bound nuclear norm regularization

Zhai, Shengyong; Li, Xiaoling; Wu, Yan; Shi, Xiaoli; Ji, Binbin; Qiu, Chao

doi:10.3389/fgene.2022.980437

Cited by 2 publications

References 61 publications

(45 reference statements)

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Investigating Factors Influencing Subjective Taste and Smell Alterations in Colorectal Cancer Patients

Wang,

Li,

Zhang

et al. 2024

Preprint

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Purpose This study aimed to assess the factors influencing self-reported taste and smell disturbances in patients with colorectal cancer. Methods A total of 152 participants were enrolled in the study. All subjects completed surveys that assessed taste and smell alterations using the Taste and Smell Survey (TSS), linear analog self-assessment (LASA), Patient-Generated Subjective Global Assessment (PG-SGA), and Pittsburgh Sleep Quality Index (PSQI). The TSS gathered data on the nature of taste and smell changes and their impact on quality of life. LASA was employed to evaluate the quality of life in cancer patients, while PG-SGA was used to indicate the nutritional status of the participants. PSQI was used to evaluate sleep quality. Results Among the 152 colorectal cancer patients, the total TSS score was 5.68 ± 2.84. No changes were observed in 5 cases (3.3%), mild changes in 58 cases (38.2%), and moderate to severe changes in 89 cases (58.6%). The severity of taste and smell disturbances increased with tumor stage, the cycle of chemotherapy, deteriorating sleep quality, and poor nutritional status, displaying significant correlations. Additionally, 83 patients (54.6%) complained of taste abnormalities, while 81 (53.3%) reported smell abnormalities. Conclusion Taste and smell disturbances are prominent in colorectal cancer patients. Taste abnormalities are significantly correlated with tumor stage, the cycle of chemotherapy, sleep quality, and nutritional status. Recognizing the high prevalence of taste and smell abnormalities and the influencing factors among patients with colorectal cancer may aid in predicting and understanding the severity of these symptoms more effectively.

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Investigating Factors Influencing Subjective Taste and Smell Alterations in Colorectal Cancer Patients

Wang,

Li,

Zhang

et al. 2024

Preprint

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Genomic and Transcriptomic Research in the Discovery and Application of Colorectal Cancer Circulating Markers

Ponomaryova,

Rykova,

Solovyova

et al. 2023

IJMS

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Colorectal cancer (CRC) is the most frequently occurring malignancy in the world. However, the mortality from CRC can be reduced through early diagnostics, selection of the most effective treatment, observation of the therapy success, and the earliest possible diagnosis of recurrences. A comprehensive analysis of genetic and epigenetic factors contributing to the CRC development is needed to refine diagnostic, therapeutic, and preventive strategies and to ensure appropriate decision making in managing specific CRC cases. The liquid biopsy approach utilizing circulating markers has demonstrated its good performance as a tool to detect the changes in the molecular pathways associated with various cancers. In this review, we attempted to brief the main tendencies in the development of circulating DNA and RNA-based markers in CRC such as cancer-associated DNA mutations, DNA methylation changes, and non-coding RNA expression shifts. Attention is devoted to the existing circulating nucleic acid-based CRC markers, the possibility of their application in clinical practice today, and their future improvement. Approaches to the discovery and verification of new markers are described, and the existing problems and potential solutions for them are highlighted.

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Identifying potential microRNA biomarkers for colon cancer and colorectal cancer through bound nuclear norm regularization

Cited by 2 publications

References 61 publications

Investigating Factors Influencing Subjective Taste and Smell Alterations in Colorectal Cancer Patients

Investigating Factors Influencing Subjective Taste and Smell Alterations in Colorectal Cancer Patients

Genomic and Transcriptomic Research in the Discovery and Application of Colorectal Cancer Circulating Markers

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