Identifying Phenotypes of Knee Osteoarthritis by Separate Quantitative Radiographic Features May Improve Patient Selection for More Targeted Treatment

Kinds, M.B.; Marijnissen, A.C.; Viergever, Max A.; Emans, Pieter J.; Lafeber, Floris P. J. G.; Welsing, Paco M J

doi:10.3899/jrheum.121004

Cited by 28 publications

(25 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently Kinds et al demonstrated that different radiographic phenotypes of OA may exist. The phenotype designated as 'bone phenotype' in which bone changes predominate over cartilage changes, during 5 years follow-up, could be distinguished from the other phenotypes by clinical and radiographic characteristics at baseline with an AUC ROC of 0.91 59 . If such clear phenotypes cannot even be identified with, in this case bone, markers, it might be questioned whether such markers would be of use in a general population.…”

Section: Treatment Efficacy Evaluated By Biochemical Marker Analysesmentioning

confidence: 99%

Osteoarthritis year 2013 in review: biomarkers; reflecting before moving forward, one step at a time

Lafeber

Spil

2013

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

In 2010, in Osteoarthritis and Cartilage, we published a comprehensive systematic review applying the consensus BIPED criteria (Burden of Disease, Investigative, Prognostic, Efficacy of Intervention and Diagnostic) criteria on serum and urinary biochemical markers for knee and hip osteoarthritis (OA) using publications that were available at that time. It appeared that none of the biochemical markers at that time were sufficiently discriminating to allow diagnosis and prognosis of OA in individual or limited numbers of patients, nor performed so consistently that they could function as primary outcome parameters in clinical trials. Also at present, almost 3 years later, this ultimate goal has not been reached (yet). Frankly, it might be questioned whether we are making the most adequate steps ahead and maybe we have to take a step back to reconsider our approaches. Some reflections are made and discussed: A critical review of molecular metabolism in OA and validation of currently investigated marker molecules in this may be vital and may lead to new and better markers. Creating cohorts in which synovial fluid (SF) is obtained in a systematic way, together with serum and urine, may also bring the field a further step ahead. Thirdly, better understanding of different phenotypes (subtypes) of OA may facilitate identification and validation of biochemical markers. Finally, the systems biology approach as discussed in the last years OA in review on biomarkers, although very complex, might provide steps forward. Looking ahead, we are optimistic but realistic in our expectations, we believe that the field can be brought forward by critically and cautiously reconsidering our approaches, and making changes forward, one step at a time.

show abstract

Section: Treatment Efficacy Evaluated By Biochemical Marker Analysesmentioning

confidence: 99%

Osteoarthritis year 2013 in review: biomarkers; reflecting before moving forward, one step at a time

Lafeber

Spil

2013

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

show abstract

“…Other OA associated processes (e.g., osteophytes, subchondral bone changes, and trabecular structure) can likewise be assessed by MRI [13]. With MRI, different phenotypes of OA can be identified and the success of treatment may be tailored depending on the phenotype and its effect can be monitored in more detail [25].…”

Section: Clinical Needsmentioning

confidence: 99%

Drugs and Polymers for Delivery Systems in OA Joints: Clinical Needs and Opportunities

et al. 2014

View full text Add to dashboard Cite

Osteoarthritis (OA) is a big burden of disease worldwide and one of the most common causes of disability in the adult population. Currently applied therapies consist of physical therapy, oral medication, intra-articular injections, and surgical interventions, with the main goal being to reduce pain and improve function and quality of life. Intra-articular (IA) administration of drugs has potential benefits in OA treatment because it minimizes systemic bioavailability and side effects associated with oral administration of drugs without compromising the therapeutic effect in the joint. However, IA drug residence time is short and there is a clinical need for a vehicle that is able to provide a sustained release long enough for IA therapy to fulfill its promise. This review summarizes the use of different polymeric systems and the incorporated drugs for IA drug delivery in the osteoarthritic joint with a primary focus on clinical needs and opportunities.

show abstract

“…From this list, 25 articles matched the inclusion criteria and were included in the systematic review ( Fig. 1) [7][8][9]. For an overview of the studies included see Table 2.…”

Section: Description Of the Included Studiesmentioning

confidence: 99%

“…One further study with high risk of bias reported similar findings. Among these seven studies, a combination of magnetic resonance imaging (MRI) and biomarkers (serum cartilage oligomeric protein [sCOMP] , N-terminal propeptide of collagen IIA [PIIANP]) [21]; x ray and clinical data [9,27], and cluster analysis (upper leg muscle strength, body mass index (BMI), severity of radiographic OA, depressive mood, radiographic scores of OA features, regional quantitative MRI measures of cartilage and bone, and selfreported knee symptoms) [7,36] were used to determine the severity of the disease. Subjects were classified in this phenotype according to the actual status of the disease and the long term outcome (2-10 years).…”

Section: Minimal Joint Diseasementioning

confidence: 99%

See 1 more Smart Citation

185 Identification of Clinical Phenotypes in Knee Osteoarthritis: A Systematic Review of the Literature

et al. 2016

View full text Add to dashboard Cite

Background: Knee Osteoarthritis (KOA) is a heterogeneous pathology characterized by a complex and multifactorial nature. It has been hypothesised that these differences are due to the existence of underlying phenotypes representing different mechanisms of the disease. Methods: The aim of this study is to identify the current evidence for the existence of groups of variables which point towards the existence of distinct clinical phenotypes in the KOA population. A systematic literature search in PubMed was conducted. Only original articles were selected if they aimed to identify phenotypes of patients aged 18 years or older with KOA. The methodological quality of the studies was independently assessed by two reviewers and qualitative synthesis of the evidence was performed. Strong evidence for existence of specific phenotypes was considered present if the phenotype was supported by at least two high-quality studies.

show abstract

Identifying Phenotypes of Knee Osteoarthritis by Separate Quantitative Radiographic Features May Improve Patient Selection for More Targeted Treatment

Abstract: Five phenotypes of radiographic progression of early knee OA were identified using separate quantitative features, which were associated with baseline radiographic features. Such phenotypes might require specific treatment and represent relevant subgroups for clinical trials.

Cited by 28 publications

References 39 publications

Osteoarthritis year 2013 in review: biomarkers; reflecting before moving forward, one step at a time

Osteoarthritis year 2013 in review: biomarkers; reflecting before moving forward, one step at a time

Drugs and Polymers for Delivery Systems in OA Joints: Clinical Needs and Opportunities

185 Identification of Clinical Phenotypes in Knee Osteoarthritis: A Systematic Review of the Literature

Contact Info

Product

Resources

About