Identifying new targets for rectal cancer treatment

Ferrandon, Sylvain; Kalady, Matthew F.

doi:10.18632/oncoscience.508

Cited by 1 publication

(1 citation statement)

References 11 publications

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“…In vitro and in vivo studies proved that increased levels of COASY were directly related to radiation resistance, possible by enhancing DNA repair efficiency and/or by activation of the PI3K/AKT/mTOR pathway. Knocking down COASY resulted in a better radiation response, including delayed tumor growth, inhibited cell proliferation, and increased activation of apoptosis after irradiation [122,123]. It would be interesting to know whether heterogeneity in response to radiation alterations in COASY expression levels is characteristic of other types of cancers.…”

Section: Cancersmentioning

confidence: 99%

The Pathophysiological Role of CoA

Czumaj

Szrok-Jurga

Hebanowska

et al. 2020

IJMS

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The importance of coenzyme A (CoA) as a carrier of acyl residues in cell metabolism is well understood. Coenzyme A participates in more than 100 different catabolic and anabolic reactions, including those involved in the metabolism of lipids, carbohydrates, proteins, ethanol, bile acids, and xenobiotics. However, much less is known about the importance of the concentration of this cofactor in various cell compartments and the role of altered CoA concentration in various pathologies. Despite continuous research on these issues, the molecular mechanisms in the regulation of the intracellular level of CoA under pathological conditions are still not well understood. This review summarizes the current knowledge of (a) CoA subcellular concentrations; (b) the roles of CoA synthesis and degradation processes; and (c) protein modification by reversible CoA binding to proteins (CoAlation). Particular attention is paid to (a) the roles of changes in the level of CoA under pathological conditions, such as in neurodegenerative diseases, cancer, myopathies, and infectious diseases; and (b) the beneficial effect of CoA and pantethine (which like CoA is finally converted to Pan and cysteamine), used at pharmacological doses for the treatment of hyperlipidemia.

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Section: Cancersmentioning

confidence: 99%