Identifying Neurophysiological Markers of Intermittent Theta Burst Stimulation in Treatment-Resistant Depression Using Transcranial Magnetic Stimulation–Electroencephalography

Strafella, Rebecca; Momi, Davide; Zomorrodi, Reza; Lissemore, Jennifer I.; Noda, Yoshihiro; Chen, Robert; Rajji, Tarek K.; Griffiths, John; Vila‐Rodriguez, Fidel; Downar, Jonathan; Daskalakis, Zafiris J.; Blumberger, Daniel M.; Voineskos, Daphne

doi:10.1016/j.biopsych.2023.04.011

Cited by 12 publications

(1 citation statement)

References 60 publications

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“…Voneskos used TMS-EEG to compare the difference between DLPFC inhibition and excitation in depression and healthy controls ( Sun et al, 2018 ; Voineskos et al, 2019 ). This technology has been applied to different clinical populations in recent years (C. T. Li et al, 2022 ; Strafella et al, 2023 ). Disease-related predictors can be found through this technology, providing markers for the pathophysiology of brain diseases.…”

Section: Introductionmentioning

confidence: 99%

TMS-evoked potential in the dorsolateral prefrontal cortex to assess the severity of depression disease: a TMS-EEG study

Meng

Liu

et al. 2023

Front. Pharmacol.

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Objective: The combined use of transcranial magnetic stimulation and electroencephalography (TMS-EEG), as a powerful technique that can non-invasively probe the state of the brain, can be used as a method to study neurophysiological markers in the field of psychiatric disorders and discover potential diagnostic predictors. This study used TMS-evoked potentials (TEPs) to study the cortical activity of patients with major depressive disorder depression (MDD) and the correlation with clinical symptoms to provide an electrophysiological basis for the clinical diagnosis.Methods: A total of 41 patients and 42 healthy controls were recruited to study. Using TMS-EEG techniques to measure the left dorsolateral prefrontal cortex (DLPFC) ‘s TEP index and evaluate the clinical symptoms of MDD patients using the Hamilton Depression Scale-24 (HAMD-24).Results: MDD subjects performing TMS-EEG on the DLPFC showed lower cortical excitability P60 index levels than healthy controls. Further analysis revealed that the degree of P60 excitability within the DLPFC of MDD patients was significantly negatively correlated with the severity of depression.Conclusion: The low levels of P60 exhibited in DLPFC reflect low excitability in MDD; the P60 component can be used as a biomarker for MDD in clinical assessment tools.

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Section: Introductionmentioning

confidence: 99%

TMS-evoked potential in the dorsolateral prefrontal cortex to assess the severity of depression disease: a TMS-EEG study

Meng

Liu

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

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Neurophysiological Biomarkers as a Springboard for the Refinement of Transcranial Magnetic Stimulation Therapy: Stratification, Mechanisms of Action, and Next Steps

Murphy

2023

Biological Psychiatry

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Transcranial Magnetic Stimulation–Electroencephalography for Biomarker Discovery in Psychiatry

Farzan

2024

Biological Psychiatry

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Identifying Neurophysiological Markers of Intermittent Theta Burst Stimulation in Treatment-Resistant Depression Using Transcranial Magnetic Stimulation–Electroencephalography

Cited by 12 publications

References 60 publications

TMS-evoked potential in the dorsolateral prefrontal cortex to assess the severity of depression disease: a TMS-EEG study

TMS-evoked potential in the dorsolateral prefrontal cortex to assess the severity of depression disease: a TMS-EEG study

Neurophysiological Biomarkers as a Springboard for the Refinement of Transcranial Magnetic Stimulation Therapy: Stratification, Mechanisms of Action, and Next Steps

Transcranial Magnetic Stimulation–Electroencephalography for Biomarker Discovery in Psychiatry

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