Identifying Motivations and Barriers to Patient Participation in Clinical Trials

Jones, Jennifer; Nyhof-Young, Joyce; Moric, Jakov; Friedman, Audrey Jusko; Wells, W. Glen; Catton, Pamela

doi:10.1080/08858190701347838

Cited by 64 publications

(58 citation statements)

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“…24,25 Factors shown to influence participation in clinical trials were grouped into four themes: altruism, personal health benefit, monetary reimbursement, and convenience.…”

Section: Discussionmentioning

confidence: 99%

“…These findings align with the literature. 24,25 The two highest scoring questions for motivating factors were AP technology could benefit others and improve the T1DM medical knowledge, with 88.9% and 77.7% of subjects reporting they strongly agree, respectively. The lowest scoring motivators of clinical trial participation were measures of convenience.…”

Section: Reliability Of Questionnairementioning

confidence: 99%

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Artificial Pancreas (AP) Clinical Trial Participants' Acceptance of Future AP Technology

Bevier

Fuller

et al. 2014

Diabetes Technology & Therapeutics

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Background: Artificial pancreas (AP) systems are currently an active field of diabetes research. This pilot study examined the attitudes of AP clinical trial participants toward future acceptance of the technology, having gained firsthand experience. Subjects and Methods: After possible influencers of AP technology adoption were considered, a 34-question questionnaire was developed. The survey assessed current treatment satisfaction, dimensions of clinical trial participant motivation, and variables of the technology acceptance model (TAM). Forty-seven subjects were contacted to complete the survey. The reliability of the survey scales was tested using Cronbach's a. The relationship of the factors to the likelihood of AP technology adoption was explored using regression analysis. Results: Thirty-six subjects (76.6%) completed the survey. Of the respondents, 86.1% were either highly likely or likely to adopt the technology once available. Reliability analysis of the survey dimensions revealed good internal consistency, with scores of >0.7 for current treatment satisfaction, convenience (motivation), personal health benefit (motivation), perceived ease of use (TAM), and perceived usefulness (TAM). Linear modeling showed that future acceptance of the AP was significantly associated with TAM and the motivation variables of convenience plus the individual item benefit to others (R 2 = 0.26, P = 0.05). When insulin pump and continuous glucose monitor use were added, the model significance improved (R 2 = 0.37, P = 0.02). Conclusions: This pilot study demonstrated that individuals with direct AP technology experience expressed high likelihood of future acceptance. Results support the factors of personal benefit, convenience, perceived usefulness, and perceived ease of use as reliable scales that suggest system adoption in this highly motivated patient population.

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“…24,25 Factors shown to influence participation in clinical trials were grouped into four themes: altruism, personal health benefit, monetary reimbursement, and convenience.…”

Section: Discussionmentioning

confidence: 99%

Section: Reliability Of Questionnairementioning

confidence: 99%

Artificial Pancreas (AP) Clinical Trial Participants' Acceptance of Future AP Technology

Bevier

Fuller

et al. 2014

Diabetes Technology & Therapeutics

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show abstract

“…Previous studies have reported that 19–85% of the patients had positive attitudes about clinical trial participation [1,4,5,7,20]. In this study, 54.5–75.6% Chinese patients were willing to join a cancer clinical trial (table 3).…”

Section: Discussionmentioning

confidence: 61%

“…An important factor in carrying out successful clinical trials is the attitude of cancer patients towards such trials. A number of studies [1,2,3,4,5,6,7,8,9,10,11,12,13] have examined the attitude of patients toward enrolling in a cancer clinical trial. Although one study [1] showed that demographic factors do not influence patients’ willingness to participate, numerous other studies [6,7,8,9,10,11,12] revealed that patients’ attitudes toward clinical trials are related to their age, gender, stage of disease, education, religiousness and socioeconomic status.…”

Section: Introductionmentioning

confidence: 99%

Participation in Cancer Clinical Trials as Viewed by Chinese Patients and Their Families

Li¹,

Yu²,

Jiang³

2010

Oncology

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Objective: To evaluate the attitude of Chinese cancer patients and their families toward clinical trials. Methods: A questionnaire was administered to 578 pairs of cancer patients and their relatives. Results: Of the 712 pairs of participants contacted, 578 pairs completed the questionnaire (effective response rate 81.2%). Over half of the participants have heard about cancer clinical trials. Among the respondents, 54.5% of the patients would consider participation in an early-stage cancer clinical trial, 68.7% with advanced cancer without previous therapy and 75.6% with advanced cancer not responding to prior therapy would consider participation in a clinical trial. Willingness to participate in a clinical trial was affected by disease stage. No significant differences were observed between the attitudes of patients and families. Participants who had never heard of clinical trials were more willing to participate in a cancer clinical trial. The major reasons for willingness to participate in a cancer clinical trial were ‘doctor suggests’ or ‘more therapy chance’. The major reasons for patients not to participate were ‘the effect of new drug is unknown’ and ‘not want to be a guinea pig’. Conclusions: Most patients were willing to join a cancer clinical trial and no significant difference was observed between the attitudes of patients and their families.

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“…Public awareness, perceptions, and consequent attitudes toward clinical research may impact regulatory policies, guide research priorities, and shape growth in the sector; however, distrust, lack of awareness, and misconceptions of clinical research have been identified as key barriers to participation in clinical trials [61][62][63][64][65]. The PARTAKE initiative is based on the premise that an informed, participating public is invaluable for the following ethical, methodological, and operational reasons:…”

Section: Partakementioning

confidence: 99%

Ethics Standards (HRPP) and Public Partnership (PARTAKE) to Address Clinical Research Concerns in India: Moving Toward Ethical, Responsible, Culturally Sensitive, and Community-Engaging Clinical Research

Burt

Gupta

Mehta

et al. 2014

J Clinic Res Bioeth

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Identifying Motivations and Barriers to Patient Participation in Clinical Trials

Abstract: The findings suggest general support of CTs. Education programs are needed to raise awareness, reduce fears, and dispel myths about CT participation.

Cited by 64 publications

References 0 publications

Artificial Pancreas (AP) Clinical Trial Participants' Acceptance of Future AP Technology

Artificial Pancreas (AP) Clinical Trial Participants' Acceptance of Future AP Technology

Participation in Cancer Clinical Trials as Viewed by Chinese Patients and Their Families

Ethics Standards (HRPP) and Public Partnership (PARTAKE) to Address Clinical Research Concerns in India: Moving Toward Ethical, Responsible, Culturally Sensitive, and Community-Engaging Clinical Research

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