Abstract:microRNAs (miRNAs) regulate gene expression at the post-transcriptional level and they play an important role in various biological processes in the human body. Therefore, identifying their regulation mechanisms is essential for the diagnostics and therapeutics for a wide range of diseases. There have been a large number of researches which use gene expression profiles to resolve this problem. However, the current methods have their own limitations. Some of them only identify the correlation of miRNA and mRNA … Show more
“…To address this requirement, we used the expression profiles of PAM50 genes from TCGA icpPAM50 to cluster the patients into multiple "environments". Since icpPAM50 is not computationally efficient to run with high dimensional data, we used top 30 miRNAs and top 800 genes as input selected by the Feature Selection Based on The Most Variant Median Absolute Deviation (FSbyMAD) [41] method as used in [42]. We considered the top 2000 (top 8 percentile) of miRNA-gene interactions based on reported scores.…”
Section: Mirdriver Outperformed Six Existing Methods For Computing MImentioning
“…To address this requirement, we used the expression profiles of PAM50 genes from TCGA icpPAM50 to cluster the patients into multiple "environments". Since icpPAM50 is not computationally efficient to run with high dimensional data, we used top 30 miRNAs and top 800 genes as input selected by the Feature Selection Based on The Most Variant Median Absolute Deviation (FSbyMAD) [41] method as used in [42]. We considered the top 2000 (top 8 percentile) of miRNA-gene interactions based on reported scores.…”
Section: Mirdriver Outperformed Six Existing Methods For Computing MImentioning
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