Identifying Lymph Node Metastasis-Related Factors in Breast Cancer Using Differential Modular and Mutational Structural Analysis

Differential network analysis reveals the key role of the ECM-receptor pathway in α-particle-induced malignant transformation

“… 23 Thus, elucidating the changes in individual nodes and edges, distinct modules, and the entire network as a whole in terms of several network centrality parameters may provide functional information to describe such biological processes. 24 Differential network analysis can capture changes between conditions in the interplay between molecules, rather than changes in single molecules, and has many applications, including illuminating the molecular basis of tissue-selective processes or disease-specific genes, 25 and identifying critical signaling pathways altered during tumor transformation and progression, 26 , 27 or between different cancer subtypes. 28 On the other hand, biological networks, including PPINs, are intrinsically modular, with proteins belonging to the same module usually sharing common functions.…”