Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration
Rory Boyle,
Diana L. Townsend,
Hannah M. Klinger
et al.
Abstract:Background
Leveraging Alzheimer’s disease (AD) imaging biomarkers and longitudinal cognitive data may allow us to establish evidence of cognitive resilience (CR) to AD pathology in-vivo. Here, we applied latent class mixture modeling, adjusting for sex, baseline age, and neuroimaging biomarkers of amyloid, tau and neurodegeneration, to a sample of cognitively unimpaired older adults to identify longitudinal trajectories of CR.
Methods
We identified… Show more
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