Identifying lipid traces of atherogenic mechanisms in human carotid plaque

Slijkhuis, Nuria; Towers, Mark; Mirzaian, Mina; Korteland, Suze-Anne; Heijs, Bram; van Gaalen, Kim; Nieuwenhuizen, Ingeborg; Nigg, Alex; van der Heiden, Kim; de Rijke, Yolanda B.; van der Lugt, Aad; Sijbrands, Eric J.G.; Claude, Emmanuelle; van Soest, Gijs

doi:10.1016/j.atherosclerosis.2023.117340

Cited by 6 publications

(3 citation statements)

References 69 publications

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“…FFA (18:1), FFA(18:2), FFA(20:4) and FFA(22:4) were identified in areas of plaques rich in macrophages, which, according to the authors, indirectly indicates their pro-inflammatory role. Phosphatidylcholines were more common in plasma, but two of them, PC(32:0) and PC(34:1), predominated in plaques [18].…”

Section: Discussionmentioning

confidence: 95%

Blood plasma lipidomic profile in atherosclerosis of brachiocephalic arteries

Lomonosova,

Gognieva,

Suvorov

et al. 2024

Preprint

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According to the World Health Organisation ischemic stroke is the second leading cause of death in the world. More frequent it is caused by brachiocephalic arteries (BCA) atherosclerosis. Timely detection of the atherosclerosis and it`s unstable course can allow a timely response to potentially dangerous changes and reduce the risk of vascular complications. Omics technologies allow us to identify new biomarkers that we can use in diagnosing diseases. The research included 90 blood plasma samples. The first group - 52 patients with severe atherosclerotic lesions, second group - 38 patients with no BCA atherosclerosis. Targeted and panoramic lipidomic profiling of blood plasma was carried out. There is a statistically significant difference (р

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Section: Discussionmentioning

confidence: 95%

Blood plasma lipidomic profile in atherosclerosis of brachiocephalic arteries

Lomonosova,

Gognieva,

Suvorov

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…FFA (18:1), FFA (18:2), FFA (20:4), and FFA (22:4) were identified in areas of plaques rich in macrophages, which, according to the authors, indirectly indicates their pro-inflammatory role. Phosphatidylcholines were more common in plasma, but two of them, PC (32:0) and PC (34:1), predominated in plaques [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

The Blood Plasma Lipidomic Profile in Atherosclerosis of the Brachiocephalic Arteries

Lomonosova,

Gognieva,

Suvorov

et al. 2024

Biomedicines

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According to the World Health Organization, ischemic stroke is the second leading cause of death in the world. Frequently, it is caused by brachiocephalic artery (BCA) atherosclerosis. Timely detection of atherosclerosis and its unstable course can allow for a timely response to potentially dangerous changes and reduce the risk of vascular complications. Omics technologies allow us to identify new biomarkers that we can use in diagnosing diseases. This research included 90 blood plasma samples. The study group comprised 52 patients with severe atherosclerotic lesions BCA, and the control group comprised 38 patients with no BCA atherosclerosis. Targeted and panoramic lipidomic profiling of their blood plasma was carried out. There was a statistically significant difference (p < 0.05) in the values of the indices saturated fatty acids (FAs), unsaturated FAs, monounsaturated FAs, omega-3, and omega-6. Based on the results on the blood plasma lipidome, we formed models that have a fairly good ability to determine atherosclerotic lesions of the brachiocephalic arteries, as well as a model for identifying unstable atherosclerotic plaques. According only to the panoramic lipidome data, divided into groups according to stable and unstable atherosclerotic plaques, a significant difference was taken into account: p value < 0.05 and abs (fold change) > 2. Unfortunately, we did not observe significant differences according to the established plasma panoramic lipidome criteria between patients with stable and unstable plaques. Omics technologies allow us to obtain data about any changes in the body. According to our data, statistically significant differences in lipidomic profiling were obtained when comparing groups with or without BCA atherosclerosis.

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“…Numerous studies have previously explored the spatial distribution and composition of lipids in carotid plaques using MSI. For instance, it was found that certain lipid species in carotid plaque colocalize with features of plaque instability, such as the colocalization of phospholipids with inflammation ( 5 , 6 , 7 , 8 ). These studies have aided in enhancing our understanding of the lipidomic landscape in carotid atherosclerosis.…”

mentioning

confidence: 99%

Spatial lipidomics of coronary atherosclerotic plaque development in a familial hypercholesterolemia swine model

Slijkhuis,

Razzi,

Korteland

et al. 2024

Journal of Lipid Research

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Identifying lipid traces of atherogenic mechanisms in human carotid plaque

Cited by 6 publications

References 69 publications

Blood plasma lipidomic profile in atherosclerosis of brachiocephalic arteries

Blood plasma lipidomic profile in atherosclerosis of brachiocephalic arteries

The Blood Plasma Lipidomic Profile in Atherosclerosis of the Brachiocephalic Arteries

Spatial lipidomics of coronary atherosclerotic plaque development in a familial hypercholesterolemia swine model

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