Identifying Issues in Fertility Preservation for Childhood and Adolescent Patients with Cancer at Pediatric Oncology Hospitals in Japan

Maezawa, Tadashi; Suzuki, Nao; Takeuchi, Hiroki; Kiyotani, Chikako; Amano, Keishiro; Keino, Dai; Okimura, Hiroyuki; Miyachi, Mitsuru; Goto, Maki; Takae, Seido; Horie, Akihito; Takita, Junko; Sago, Haruhiko; Hirayama, Masahiro; Ikeda, Tomoaki; Matsumoto, Kimikazu

doi:10.1089/jayao.2021.0088

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…Patients with cancer in Japan request information about fertility preservation and psychological support [ 29 ]. However, a system for providing explanatory materials for fertility preservation and encouraging cooperation at the physician and hospital levels are insufficient support for AYA patients with cancer [ 30 ]. Therefore, these cancer types might be related to mental health care use.…”

Section: Discussionmentioning

confidence: 99%

Mental health care use and related factors in adolescents and young adults with cancer

Hirayama¹,

Ikezawa

Okubo

et al. 2023

Support Care Cancer

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Purpose The actual state of mental health care use and related factors in adolescent and young adult (AYA) patients with cancer is not well understood in Japan. This study aimed to (1) examine the actual state of mental health care use among AYA patients with cancer and (2) describe socio-demographic and related factors associated with mental health care use. Methods We retrospectively reviewed the medical records of AYA patients with cancer aged 15–39 who first visited the National Cancer Center Hospital in Japan (NCCH) between January 2018 and December 2020. Logistic regression was used to analyze the association between social background characteristics and mental health care use. The association between the patient's course of cancer treatment and mental health care use was analyzed to help identify which patients might benefit from early mental health intervention. Results Among 1,556 patients, 945 AYA patients with cancer were registered. The median age at the time of the study was 33 years (range, 15–39 years). The prevalence of mental health care use was 18.0% (170/945). Age 15–19 years, female gender, urogenital cancer, gynecological cancer, bone or soft tissue cancer, head and neck cancer, and stage II–IV disease were associated with mental health care use. Regarding treatment, palliative treatment, chemotherapy, and hematopoietic stem cell transplantation were associated with mental health care use. Conclusion Factors associated with mental health care use were identified. Our findings potentially contribute to psychological support interventions for AYA patients with cancer.

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Section: Discussionmentioning

confidence: 99%

Mental health care use and related factors in adolescents and young adults with cancer

Hirayama¹,

Ikezawa

Okubo

et al. 2023

Support Care Cancer

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“…More than 80% of childhood cancer survivors have long-term survival into adulthood. These survivors have a 1.48-fold higher risk of POF than their siblings ( 14 ). Anti-Müllerian hormone (AMH) was detected falling rapidly in both prepubertal and pubertal girls undergoing cancer therapy ( 15 ).…”

Section: Risks On Ovarian Function During the Treatment Of Bcmentioning

confidence: 99%

Artificial Ovary for Young Female Breast Cancer Patients

et al. 2022

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In recent decades, there has been increasing attention toward the quality of life of breast cancer (BC) survivors. Meeting the growing expectations of fertility preservation and the generation of biological offspring remains a great challenge for these patients. Conventional strategies for fertility preservation such as oocyte and embryo cryopreservation are not suitable for prepubertal cancer patients or in patients who need immediate cancer therapy. Ovarian tissue cryopreservation (OTC) before anticancer therapy and autotransplantation is an alternative option for these specific indications but has a risk of retransplantation malignant cells. An emerging strategy to resolve these issues is by constructing an artificial ovary combined with stem cells, which can support follicle proliferation and ensure sex hormone secretion. This promising technique can meet both demands of improving the quality of life and meanwhile fulfilling their expectation of biological offspring without the risk of cancer recurrence.

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Challenges to Widespread Use of Fertility Preservation Facilities for Pediatric Cancer Patients in Japan

Maezawa

Suzuki

Takeuchi

et al. 2024

Journal of Adolescent and Young Adult Oncology

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Identifying Issues in Fertility Preservation for Childhood and Adolescent Patients with Cancer at Pediatric Oncology Hospitals in Japan

Cited by 4 publications

References 14 publications

Mental health care use and related factors in adolescents and young adults with cancer

Mental health care use and related factors in adolescents and young adults with cancer

Artificial Ovary for Young Female Breast Cancer Patients

Challenges to Widespread Use of Fertility Preservation Facilities for Pediatric Cancer Patients in Japan

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