Identifying Individuals With Autism in a State Facility for Adolescents Adjudicated as Sexual Offenders

Sutton, Lawrence R.; Hughes, Tammy L.; Huang, Ann; Lehman, Cathryn; Paserba, David; Talkington, Vanessa; Taormina, Rochelle; Walters, Jessie B.; Fenclau, Eric; Marshall, Stephanie

doi:10.1177/1088357612462060

Cited by 63 publications

(19 citation statements)

References 24 publications

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“…This finding was also observed in our previous studies after MSC transplantation to BTBR mice [ 5 ]. Considering the growing recognition that some adolescents and young adults with ASD may exhibit inappropriate sexual behaviors [ 22 , 23 ], the fact that MSC-exo treatment also does not enhance sexual arousal is an advantage. As compared, the C57BL MSC-exo group did not present behavioral changes in their ultrasonic vocalizations and social interactions toward both males and females.…”

Section: Discussionmentioning

confidence: 99%

Intranasal administration of exosomes derived from mesenchymal stem cells ameliorates autistic-like behaviors of BTBR mice

et al. 2018

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Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by three core symptoms that include social interaction deficits, cognitive inflexibility, and communication disorders. They have been steadily increasing in children over the past several years, with no effective treatment. BTBR T+tf/J (BTBR) mice are an accepted model of evaluating autistic-like behaviors as they present all core symptoms of ASD. We have previously shown that transplantation of human bone marrow mesenchymal stem cells (MSC) to the lateral ventricles of BTBR mice results in long lasting improvement in their autistic behavioral phenotypes. Recent studies point exosomes as the main mediators of the therapeutic effect of MSC. Here, we tested whether treatment with the exosomes secreted from MSC (MSC-exo) will show similar beneficial effects. We found that intranasal administration of MSC-exo increased male to male social interaction and reduced repetitive behaviors. Moreover, the treatment led to increases of male to female ultrasonic vocalizations and significant improvement in maternal behaviors of pup retrieval. No negative symptoms were detected following MSC-exo intranasal treatments in BTBR or healthy C57BL mice. The marked beneficial effects of the exosomes in BTBR mice may translate to a novel, non-invasive, and therapeutic strategy to reduce the symptoms of ASD.Electronic supplementary materialThe online version of this article (10.1186/s13229-018-0240-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Intranasal administration of exosomes derived from mesenchymal stem cells ameliorates autistic-like behaviors of BTBR mice

et al. 2018

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“…As such, there is some evidence that individuals with ASD are at increased risk for problematic sexual behaviors that can include undesired touching, public masturbation and other illegal activity [1]. Few investigations of problem sexual behavior in ASD exist, but one related study found that 60% of a sample of 37 male adolescents adjudicated for sexual offenses and sentenced to treatment met diagnostic criteria for ASD [38]. Further, even when problem behaviors are not illegal, inappropriate sexual behaviors can limit employment and inclusion opportunities for individuals with ASD [20].…”

Section: Positive and Respectful Approach To Sexuality And Sexual Relmentioning

confidence: 99%

Sex Education, Sexual Health, and Autism Spectrum Disorder

Loftin

S²

2015

Pediat Therapeut

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Sex education is an important but often inadequately addressed topic for patients with autism spectrum disorder. A dominant theory in autism, Theory of Mind, helps to explain why the sex education needs of people with this disorder are unique. This paper argues the importance of high quality sex education from the perspective of the World Health Organization's recent comprehensive definition of sexual health. Each point from the World Health Organization's definition is addressed with discussion of its application to people with autism spectrum disorder, suggestions for remediation, and public health implications. Seven points are addressed: physical well-being in relation to sexuality; emotional and mental well-being in relation to sexuality; social well-being in relation to sexuality; disease, dysfunction, or infirmity; positive and respectful approaches to sexuality and sexual relationships; freedom from coercion and violence; and freedom from discrimination. Sex education is important to the quality of life and safety of people with autism. The needs of this population are apparent in all seven areas identified.

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“…However, establishing the state factors for clients with comorbid Level 2/3 autism and an ID appears to be an outstanding area in the ITSO. For example, whilst there is ample evidence that clients with autism and ID may experience increased emotional and behavioural regulation difficulties (Sutton et al, 2013) it is unclear how the factors 'need for intimacy' due to 'loneliness, inadequacy and low self-esteem' may apply to a person with autism where there is a high likelihood of them experiencing mind-blindness and alexithymia (Brewer, Cook and Bird, 2016).…”

Section: )mentioning

confidence: 99%

The multi-component model of harmful sexual behaviour for people with autism and co-morbid intellectual disabilities – a theory and practice guide

Worthington

2019

JFP

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Purpose The purpose of this paper is to explore to what extent neuro-typical theories of sexual offending apply to clients with Levels 2 and 3 autism with a co-morbid intellectual disability (ID). The paper develops a model of harmful sexual behaviour (HSB) for this client group and makes suggestions for how these behaviours can be understood and reduced. Design/methodology/approach The revised Integrated Theory of Sexual Offending (ITSO) (Ward and Beech, 2016) is used as a starting framework to understand HSB in this client group. This attends to specific neuropsychological systems, brain development, motivation and emotional processing. Findings The revised ITSO has some utility in understanding HSB in this client group. This is improved when neuro-atypical specific state factors are identified. Practical ways of establishing these state factors are made which attend to the function of the behaviour in line with “Good Lives” model of rehabilitation. Research limitations/implications Recommendations for ways in which the function of HSB in this client group can be identified are made as well as recommendations for how treatment can be tailored dependent on the function of behaviour in this client group. Practical implications The paper makes practical recommendations for how interventions for people with ID and autism in line with Ward, Clack and Haig’s (2016) Abductive Theory of Method which noted that interventions should be adopted to consider wider explanations for offending thus acknowledging that treatment could extend beyond cognitive behavioural therapy for clinical phenomena. Future treatments for clients with autism and LD are suggested which attend to sensory needs, teaching alternative communication strategies for seeking out “deep pressure” or attention in ways that do not involve sexual offending, using picture communication, information technology or Makaton to communicate needs or using social stories to explain the consequences of behaviour. In addition, neuro-atypical interventions which attend to the neuropsychological functioning of clients could also be included in treatment for neuro-typical clients, thus ensuring that interventions attend to every aspect of the ITSO and not purely clinical phenomena. Social implications Enhancing treatment interventions for clients with ID and autism could both reduce risk and enhance quality of life for this client group. Originality/value Much of the work to date exploring HSB in clients with autism has attended to clients with Level 1 autism or those without an additional ID. This paper provides practitioners with a theory upon which to understand HSB in clients with a dual diagnosis of Levels 2/3 autism and an ID as well as practical recommendations for reducing HSB in this client group.

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Identifying Individuals With Autism in a State Facility for Adolescents Adjudicated as Sexual Offenders

Cited by 63 publications

References 24 publications

Intranasal administration of exosomes derived from mesenchymal stem cells ameliorates autistic-like behaviors of BTBR mice

Intranasal administration of exosomes derived from mesenchymal stem cells ameliorates autistic-like behaviors of BTBR mice

Sex Education, Sexual Health, and Autism Spectrum Disorder

The multi-component model of harmful sexual behaviour for people with autism and co-morbid intellectual disabilities – a theory and practice guide

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